Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30123 |
Resumo: | 2020-01-01 |
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Castro, Andressa da SilvaAlves, Celene Maria de Oliveira SimõesAngeloni, Mariana BodiniGomes, Angélica OliveiraBarbosa, Bellisa de FreitasFranco, Priscila SilvaSilva, Deise Aparecida de OliveiraMartins Filho, Olindo AssisMineo, José RobertoMineo, Tiago Wilson PatriarcaFerro, Eloisa Amália Vieira2018-11-21T13:27:50Z2018-11-21T13:27:50Z2013CASTRO, Andressa da Silva et al. Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection. Placenta, v. 34, n. 3, p. 240-7, 20130143-4004https://www.arca.fiocruz.br/handle/icict/3012310.1016/j.placenta.2012.12.006engElsevierCélula TrofoblásticaMonócitosToxoplasma gondiicitocinasTrophoblast cellMonocytesToxoplasma gondiiCytokinesTrophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, Brazil/Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratoro de Imunoparasitologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratoro de Imunoparasitologia. Uberlândia, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Doença de Chagas. Belo Horizonte, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratoro de Imunoparasitologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratoro de Imunoparasitologia. Uberlândia, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Histologia e Embriologia. Uberlândia, MG, BrazilIntroduction: Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Trophoblast cells constitute an important maternal–fetal barrier, with monocytes concentrating around them. Thus, interactions between trophoblasts and monocytes are important for maintaining a successful pregnancy, especially in cases of infection. This study aimed to evaluate the role of trophoblast cells (BeWo line) on monocyte (THP-1 line) activity in the presence or absence of T. gondii infection. Methods: THP-1 cells were stimulated with supernatants of BeWo cells, previously infected or not with T. gondii, and then infected with parasites. The supernatant of both cells were collected and analyzed for cytokine production and T. gondii proliferation in THP-1 cells was determined. Results: The results showed that after infection, the pattern of cytokines secreted by THP-1 and BeWo cells was characterized as a pro-inflammatory profile. Furthermore, supernatant of BeWo cells infected or not, was able to change the cytokine profile secreted by infected THP-1 cells, and this supernatant became THP-1 cells more able to control T. gondii proliferation than those that had not been stimulated. Discussion: This effect was associated with secretion of interleukin (IL)-6 by the THP-1 cells and soluble factors secreted by BeWo cells, such as IL-6 and MIF. Conclusion: Together, these results suggest that trophoblast cells are able to modulate monocyte activity, resulting in the control of T. gondii infection and subsequent maintenance of pregnancy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30123/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALTrophoblast cells are able to regulate monocyte.pdfTrophoblast cells are able to regulate monocyte.pdfapplication/pdf552663https://www.arca.fiocruz.br/bitstream/icict/30123/2/Trophoblast%20cells%20are%20able%20to%20regulate%20monocyte.pdf84a1f1bb7961d4553afb4e9279670b5aMD52TEXTTrophoblast cells are able to regulate monocyte.pdf.txtTrophoblast cells are able to regulate monocyte.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| title |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| spellingShingle |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection Castro, Andressa da Silva Célula Trofoblástica Monócitos Toxoplasma gondii citocinas Trophoblast cell Monocytes Toxoplasma gondii Cytokines |
| title_short |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| title_full |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| title_fullStr |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| title_full_unstemmed |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| title_sort |
Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection |
| author |
Castro, Andressa da Silva |
| author_facet |
Castro, Andressa da Silva Alves, Celene Maria de Oliveira Simões Angeloni, Mariana Bodini Gomes, Angélica Oliveira Barbosa, Bellisa de Freitas Franco, Priscila Silva Silva, Deise Aparecida de Oliveira Martins Filho, Olindo Assis Mineo, José Roberto Mineo, Tiago Wilson Patriarca Ferro, Eloisa Amália Vieira |
| author_role |
author |
| author2 |
Alves, Celene Maria de Oliveira Simões Angeloni, Mariana Bodini Gomes, Angélica Oliveira Barbosa, Bellisa de Freitas Franco, Priscila Silva Silva, Deise Aparecida de Oliveira Martins Filho, Olindo Assis Mineo, José Roberto Mineo, Tiago Wilson Patriarca Ferro, Eloisa Amália Vieira |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Andressa da Silva Alves, Celene Maria de Oliveira Simões Angeloni, Mariana Bodini Gomes, Angélica Oliveira Barbosa, Bellisa de Freitas Franco, Priscila Silva Silva, Deise Aparecida de Oliveira Martins Filho, Olindo Assis Mineo, José Roberto Mineo, Tiago Wilson Patriarca Ferro, Eloisa Amália Vieira |
| dc.subject.other.pt_BR.fl_str_mv |
Célula Trofoblástica Monócitos Toxoplasma gondii citocinas |
| topic |
Célula Trofoblástica Monócitos Toxoplasma gondii citocinas Trophoblast cell Monocytes Toxoplasma gondii Cytokines |
| dc.subject.en.pt_BR.fl_str_mv |
Trophoblast cell Monocytes Toxoplasma gondii Cytokines |
| description |
2020-01-01 |
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2013 |
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2013 |
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2018-11-21T13:27:50Z |
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2018-11-21T13:27:50Z |
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CASTRO, Andressa da Silva et al. Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection. Placenta, v. 34, n. 3, p. 240-7, 2013 |
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https://www.arca.fiocruz.br/handle/icict/30123 |
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0143-4004 |
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10.1016/j.placenta.2012.12.006 |
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CASTRO, Andressa da Silva et al. Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection. Placenta, v. 34, n. 3, p. 240-7, 2013 0143-4004 10.1016/j.placenta.2012.12.006 |
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