Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42740 |
Resumo: | Caian L Vinhaes e Bruno B Andrade - Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil. |
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Narendran, GopalanJyotheeswaran, KeerthanaSenguttuvan, ThirumaranVinhaes, Caian L.Santhanakrishnan, Ramesh K.Manoharan, TamizhselvanSelvaraj, AnbhalaganChandrasekaran, PadmapriyadarsiniMenon, Pradeep A.Bhavani, Kannabiran P.Reddy, DevarajuluNarayanan, RavichandranSubramanyam, BalajiSathyavelu, SekharKrishnaraja, RajaKalirajan, PownrajAngamuthu, DhanalakshmiSusaimuthu, Stella MaryGanesan, Ranjit R. K.Tripathy, Srikanth P.Swaminathan, SoumyaAndrade, Bruno de Bezerril2020-08-13T11:44:02Z2020-08-13T11:44:02Z2020NARENDRAN, Gopalan et al. Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV. International Journal of Infectious Diseases, v. 98, p. 261–267, 2020.1201-9712https://www.arca.fiocruz.br/handle/icict/4274010.1016/j.ijid.2020.06.097Caian L Vinhaes e Bruno B Andrade - Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.a National Institute for Research in Tuberculosis, Indian Council of Medical Research Chennai, Tamil Nadu, India b Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil c Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil d Curso de Medicina, Faculdade de Tecnologia e Ciências (UniFTC), Salvador, Brazil e Government Hospital of Thoracic Medicine, Tambaram Sanatorium, Chennai, Tamil Nadu, India f Rajiv Gandhi Government General Hospital, Park Town, Chennai, Tamil Nadu, India g Government Rajaji Hospital, Madurai, Tamil Nadu, India hWorld Health Organization, Geneva, Switzerland i Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil j Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil kWellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaIrini Sereti (National Institutes of Health [NIH], USA), Brian Porter (NIH), Alan Sher (NIH), Lis Antonelli (Fundação Oswaldo Cruz, Brazil), Cynthia Lassnoff (NIH), Christopher Whalen (NIH), Michael Duvenhage (NIH) and Drs Thomas Nutman, Subash Babu and Aleyamma Thomas from NIH who provided valuable input and periodical guidance. We deeply appreciate the work of the team members at the National Institute of Research in Tuberculosis (NIRT), India: Lokeshwaran Nithyananthan, Solomon Priyaku- mar, Rajasekaran Subramani and Ramesh Babu, for clinical procedures; Syed Hissar, Kannan, Murugesan, Sudha Subrama- nium, Luke Elizabeth Hanna for lab support. We also thank the entire team of medical officers and nursing staff of NIRT- Chennai, NIRT-Madurai and the Government Hospital of Thoracic Medicine. We finally acknowledge the excellent secretarial assistance given by Sanathanakumar Natarajan and Maheshwari Theyagarajan (NIRT). This retrospective study did not receive specific funding. The work from BBA was supported by the Intramural Research programme of the Fundação Oswaldo Cruz (FIOCRUZ), and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior scientist fellowship). CLV received fellowship from CNPq. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Múltipla – Ver em notas.Objective: The influence of tuberculosis (TB)-immune reconstitution inflammatory syndrome (IRIS) on TB treatment outcomes and its risk factors were investigated among people with human immunodeficiency virus (HIV) and co-infected with TB. Methods: Newly diagnosed, culture-confirmed, pulmonary TB patients with HIV and enrolled in a clinical trial (NCT00933790) were retrospectively analysed for IRIS occurrence. Risk factors and TB outcomes (up to 18 months after initiation of anti-TB treatment [ATT]) were compared between people who experienced IRIS (IRIS group) and those who did not (non-IRIS group). Results: TB-IRIS occurred in 82 of 292 (28%) participants. Significant baseline risk factors predisposing to TB-IRIS occurrence in univariate analysis were: lower CD4+ T-cell count, CD4/CD8 ratio, haemoglobin levels, presence of extra-pulmonary TB focus, and higher HIV viral load; the last two retained significance in the multivariate analysis. After 2 months of ATT commencement, sputum smear conversion was documented in 45 of 80 (56.2%) vs. 124 of 194 (63.9%) (p=0.23), culture conversion was in 75 of 80 (93.7%) vs. 178 of 194 (91.7%) (p=0.57) and the median decline in viral load (log10copies/mm3) was 2.7 in the IRIS vs. 1.1 in the non-IRIS groups (p<0.0001), respectively. An unfavourable response to TB therapy was detected in 17 of 82 (20.7%) and 28 of 210 (13.3%) in the IRIS and non-IRIS groups, respectively (p=0.14). Conclusions: TB-IRIS frequently occurred in people with advanced HIV infection and in those who presented with extra-pulmonary TB lesions, without influencing subsequent TB treatment outcomes.engElsevierHIVTuberculoseTerapia anti-retroviralTratamento anti-TBÍRISReação paradoxalHIVTuberculosisAntiretroviral therapyAnti-TB treatmentIRISParadoxical reactionCharacteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42740/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNarendran Gopalan Characteristics.pdfNarendran Gopalan 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| dc.title.pt_BR.fl_str_mv |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| title |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| spellingShingle |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV Narendran, Gopalan HIV Tuberculose Terapia anti-retroviral Tratamento anti-TB ÍRIS Reação paradoxal HIV Tuberculosis Antiretroviral therapy Anti-TB treatment IRIS Paradoxical reaction |
| title_short |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| title_full |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| title_fullStr |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| title_full_unstemmed |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| title_sort |
Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV |
| author |
Narendran, Gopalan |
| author_facet |
Narendran, Gopalan Jyotheeswaran, Keerthana Senguttuvan, Thirumaran Vinhaes, Caian L. Santhanakrishnan, Ramesh K. Manoharan, Tamizhselvan Selvaraj, Anbhalagan Chandrasekaran, Padmapriyadarsini Menon, Pradeep A. Bhavani, Kannabiran P. Reddy, Devarajulu Narayanan, Ravichandran Subramanyam, Balaji Sathyavelu, Sekhar Krishnaraja, Raja Kalirajan, Pownraj Angamuthu, Dhanalakshmi Susaimuthu, Stella Mary Ganesan, Ranjit R. K. Tripathy, Srikanth P. Swaminathan, Soumya Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Jyotheeswaran, Keerthana Senguttuvan, Thirumaran Vinhaes, Caian L. Santhanakrishnan, Ramesh K. Manoharan, Tamizhselvan Selvaraj, Anbhalagan Chandrasekaran, Padmapriyadarsini Menon, Pradeep A. Bhavani, Kannabiran P. Reddy, Devarajulu Narayanan, Ravichandran Subramanyam, Balaji Sathyavelu, Sekhar Krishnaraja, Raja Kalirajan, Pownraj Angamuthu, Dhanalakshmi Susaimuthu, Stella Mary Ganesan, Ranjit R. K. Tripathy, Srikanth P. Swaminathan, Soumya Andrade, Bruno de Bezerril |
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author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Narendran, Gopalan Jyotheeswaran, Keerthana Senguttuvan, Thirumaran Vinhaes, Caian L. Santhanakrishnan, Ramesh K. Manoharan, Tamizhselvan Selvaraj, Anbhalagan Chandrasekaran, Padmapriyadarsini Menon, Pradeep A. Bhavani, Kannabiran P. Reddy, Devarajulu Narayanan, Ravichandran Subramanyam, Balaji Sathyavelu, Sekhar Krishnaraja, Raja Kalirajan, Pownraj Angamuthu, Dhanalakshmi Susaimuthu, Stella Mary Ganesan, Ranjit R. K. Tripathy, Srikanth P. Swaminathan, Soumya Andrade, Bruno de Bezerril |
| dc.subject.other.pt_BR.fl_str_mv |
HIV Tuberculose Terapia anti-retroviral Tratamento anti-TB ÍRIS Reação paradoxal |
| topic |
HIV Tuberculose Terapia anti-retroviral Tratamento anti-TB ÍRIS Reação paradoxal HIV Tuberculosis Antiretroviral therapy Anti-TB treatment IRIS Paradoxical reaction |
| dc.subject.en.pt_BR.fl_str_mv |
HIV Tuberculosis Antiretroviral therapy Anti-TB treatment IRIS Paradoxical reaction |
| description |
Caian L Vinhaes e Bruno B Andrade - Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil. |
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2020 |
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2020-08-13T11:44:02Z |
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2020-08-13T11:44:02Z |
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2020 |
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NARENDRAN, Gopalan et al. Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV. International Journal of Infectious Diseases, v. 98, p. 261–267, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42740 |
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1201-9712 |
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10.1016/j.ijid.2020.06.097 |
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NARENDRAN, Gopalan et al. Characteristics of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and its influence on tuberculosis treatment outcomes in persons living with HIV. International Journal of Infectious Diseases, v. 98, p. 261–267, 2020. 1201-9712 10.1016/j.ijid.2020.06.097 |
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