HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade

Detalhes bibliográficos
Autor(a) principal: Amoussa, Adjile Edjide Roukiyath
Data de Publicação: 2017
Outros Autores: Wilkinson, Eduan, Giovanetti, Marta, Rego, Filipe Ferreira de Almeida, Araujo, Thessika Hialla Almeida, Gonçalves, Marilda de Souza, Oliveira, Tulio de, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18035
Resumo: CNPq (200328/2015-8) Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brasil. E.W. and T.d.O are funded by a Medical Research Council flagship grant of the Republic of South Africa (MRC-RFA-UFSP-01-2013/UKZN HIVEPI)
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spelling Amoussa, Adjile Edjide RoukiyathWilkinson, EduanGiovanetti, MartaRego, Filipe Ferreira de AlmeidaAraujo, Thessika Hialla AlmeidaGonçalves, Marilda de SouzaOliveira, Tulio deAlcantara, Luiz Carlos Júnior2017-03-14T16:30:50Z2017-03-14T16:30:50Z2017AMOUSSA, A. E. R. et al. HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade. Infection, Genetics and Evolution, v. 48, p. 95–101, 2017.1567-1348https://www.arca.fiocruz.br/handle/icict/1803510.1016/j.meegid.2016.12.005CNPq (200328/2015-8) Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brasil. E.W. and T.d.O are funded by a Medical Research Council flagship grant of the Republic of South Africa (MRC-RFA-UFSP-01-2013/UKZN HIVEPI)Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, BrasilUniversity of Kwazulu-Natal. Africa Centre for Health and Population Studies. Durban, South AfricaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / University of Rome “Tor Vergata”. ItalyFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Catholic University of Salvador. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Bahia Foundation for Development of Science. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Kwazulu-Natal. Africa Centre for Health and Population Studies. Durban, South AfricaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilHuman T-lymphotropic virus (HTLV) is an endemic virus in some parts of the world, with Africa being home to most of the viral genetic diversity. In Brazil, HTLV-1 is endemic amongst Japanese and African immigrant populations. Multiple introductions of the virus in Brazil from other epidemic foci were hypothesized. The long terminal repeat (LTR) region of HTLV-1 was used to infer the origin of the virus in Brazil, using phylogenetic analysis. Methods: LTR sequences were obtained from the HTLV-1 database (http://htlv1db.bahia.fiocruz.br). Sequences were aligned and maximum-likelihood and Bayesian tree topologies were inferred. Brazilian specific clusters were identified and molecular-clock and coalescent models were used to estimate each cluster's time to the most recent common ancestor (tMRCA). Results: Three Brazilian clusters were identified with a posterior probability ranged from 0.61 to 0.99. Molecular clock analysis of these three clusters dated back their respective tMRCAs between the year 1499 and the year 1668. Additional analysis also identified a close association between Brazilian sequences and new sequences from South Africa. Conclusion: Our results support the hypothesis of amultiple introductions of HTLV-1 into Brazil,with the majority of introductions occurring in the post-Colombian period. Our results further suggest that HTLV-1 introduction into Brazil was facilitated by the trans-Atlantic slave trade fromendemic areas of Africa. The close association between southern African and Brazilian sequences also suggested that greater numbers of the southern African Bantu population might also have been part of the slave trade than previously thoughengElsevierHTLV-1BrasilÁfrica do SulEscravosHTLV-1BrazilSouthern AfricaTrans-Atlantic slave tradeHTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave tradeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18035/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAmoussa AER HTLV-1aA introduction....pdfAmoussa AER HTLV-1aA 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dc.title.pt_BR.fl_str_mv HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
title HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
spellingShingle HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
Amoussa, Adjile Edjide Roukiyath
HTLV-1
Brasil
África do Sul
Escravos
HTLV-1
Brazil
Southern Africa
Trans-Atlantic slave trade
title_short HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
title_full HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
title_fullStr HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
title_full_unstemmed HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
title_sort HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade
author Amoussa, Adjile Edjide Roukiyath
author_facet Amoussa, Adjile Edjide Roukiyath
Wilkinson, Eduan
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Araujo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Oliveira, Tulio de
Alcantara, Luiz Carlos Júnior
author_role author
author2 Wilkinson, Eduan
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Araujo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Oliveira, Tulio de
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amoussa, Adjile Edjide Roukiyath
Wilkinson, Eduan
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Araujo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Oliveira, Tulio de
Alcantara, Luiz Carlos Júnior
dc.subject.other.pt_BR.fl_str_mv HTLV-1
Brasil
África do Sul
Escravos
topic HTLV-1
Brasil
África do Sul
Escravos
HTLV-1
Brazil
Southern Africa
Trans-Atlantic slave trade
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Brazil
Southern Africa
Trans-Atlantic slave trade
description CNPq (200328/2015-8) Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brasil. E.W. and T.d.O are funded by a Medical Research Council flagship grant of the Republic of South Africa (MRC-RFA-UFSP-01-2013/UKZN HIVEPI)
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-03-14T16:30:50Z
dc.date.available.fl_str_mv 2017-03-14T16:30:50Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AMOUSSA, A. E. R. et al. HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade. Infection, Genetics and Evolution, v. 48, p. 95–101, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18035
dc.identifier.issn.pt_BR.fl_str_mv 1567-1348
dc.identifier.doi.none.fl_str_mv 10.1016/j.meegid.2016.12.005
identifier_str_mv AMOUSSA, A. E. R. et al. HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade. Infection, Genetics and Evolution, v. 48, p. 95–101, 2017.
1567-1348
10.1016/j.meegid.2016.12.005
url https://www.arca.fiocruz.br/handle/icict/18035
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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