Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype

Detalhes bibliográficos
Autor(a) principal: Jácome, Fernanda Cunha
Data de Publicação: 2021
Outros Autores: Caldas, Gabriela Cardoso, Rasinhas, Arthur da Costa, Almeida, Ana Luisa Teixeira de, Souza, Daniel Dias Coutinho de, Paulino, Amanda Carlos, Silva, Marcos Alexandre Nunes da, Barth, Ortrud Monika, Santos, Flávia Barreto dos, Vieira, Debora Ferreira Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49071
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.
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spelling Jácome, Fernanda CunhaCaldas, Gabriela CardosoRasinhas, Arthur da CostaAlmeida, Ana Luisa Teixeira deSouza, Daniel Dias Coutinho dePaulino, Amanda CarlosSilva, Marcos Alexandre Nunes daBarth, Ortrud MonikaSantos, Flávia Barreto dosVieira, Debora Ferreira Barreto2021-09-14T11:12:26Z2021-09-14T11:12:26Z2021JÁCOME, Fernanda Cunha et al. Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype. Pathogens, v. 10, 1084, 20 p, 2021.2076-7817https://www.arca.fiocruz.br/handle/icict/4907110.3390/pathogens10091084engMDPIDengue 2Linhagens asiáticas / americanasBALB/c miceRimHistopatologia e microscopia eletrônica de transmissãoDengue 2Asian/American lineagesBALB/c miceKidneyHistopathology and transmission electron microscopyBrazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotypeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.Dengue virus type 2 (DENV-2) is, traditionally, the most studied serotype due to its association with explosive outbreaks and severe cases. In Brazil, almost 20 years after the first introduction in the 1990s, a new lineage (Lineage II) of the DENV-2 Asian/American genotype emerged and caused an epidemic with severe cases and hospitalizations. Severe dengue includes multiple organ failure, and renal involvement can be potentially related to increased mortality. In order to better understand the role of DENV infection in renal injury, here we aimed to investigate the outcomes of infection with two distinct lineages of DENV-2 Asian/American genotype in the kidney of a murine model. BALB/c mice were infected with Lineages I and II and tissues were submitted to histopathology, immunohistochemistry, histomorphometry and ultrastructural analysis. Blood urea nitrogen (BUN) was detected in blood sample accessed by cardiac puncture. A tendency in kidney weight increase was observed in mice infected with both lineages, but urea levels, on average, were increased only in mice infected with Lineage II. The DENV antigen was detected in the tissue of mice infected with Lineage II and morphological changes were similar to those observed in human dengue cases. Furthermore, the parameters such as organ weight, urea levels and morphometric analysis, showed significant differences between the two lineages in the infected BALB/c, which was demonstrated to be a suitable experimental model for dengue pathophysiology studies in kidneys.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49071/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAmandaPaulino_OrtrudBarth_etal_IOC_2021.pdfAmandaPaulino_OrtrudBarth_etal_IOC_2021.pdfapplication/pdf5996131https://www.arca.fiocruz.br/bitstream/icict/49071/2/AmandaPaulino_OrtrudBarth_etal_IOC_2021.pdf034425af2db685a2d9c4f53c71c02025MD52TEXTAmandaPaulino_OrtrudBarth_etal_IOC_2021.pdf.txtAmandaPaulino_OrtrudBarth_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
title Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
spellingShingle Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
Jácome, Fernanda Cunha
Dengue 2
Linhagens asiáticas / americanas
BALB/c mice
Rim
Histopatologia e microscopia eletrônica de transmissão
Dengue 2
Asian/American lineages
BALB/c mice
Kidney
Histopathology and transmission electron microscopy
title_short Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
title_full Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
title_fullStr Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
title_full_unstemmed Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
title_sort Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype
author Jácome, Fernanda Cunha
author_facet Jácome, Fernanda Cunha
Caldas, Gabriela Cardoso
Rasinhas, Arthur da Costa
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Paulino, Amanda Carlos
Silva, Marcos Alexandre Nunes da
Barth, Ortrud Monika
Santos, Flávia Barreto dos
Vieira, Debora Ferreira Barreto
author_role author
author2 Caldas, Gabriela Cardoso
Rasinhas, Arthur da Costa
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Paulino, Amanda Carlos
Silva, Marcos Alexandre Nunes da
Barth, Ortrud Monika
Santos, Flávia Barreto dos
Vieira, Debora Ferreira Barreto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jácome, Fernanda Cunha
Caldas, Gabriela Cardoso
Rasinhas, Arthur da Costa
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Paulino, Amanda Carlos
Silva, Marcos Alexandre Nunes da
Barth, Ortrud Monika
Santos, Flávia Barreto dos
Vieira, Debora Ferreira Barreto
dc.subject.other.pt_BR.fl_str_mv Dengue 2
Linhagens asiáticas / americanas
BALB/c mice
Rim
Histopatologia e microscopia eletrônica de transmissão
topic Dengue 2
Linhagens asiáticas / americanas
BALB/c mice
Rim
Histopatologia e microscopia eletrônica de transmissão
Dengue 2
Asian/American lineages
BALB/c mice
Kidney
Histopathology and transmission electron microscopy
dc.subject.en.pt_BR.fl_str_mv Dengue 2
Asian/American lineages
BALB/c mice
Kidney
Histopathology and transmission electron microscopy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-14T11:12:26Z
dc.date.available.fl_str_mv 2021-09-14T11:12:26Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JÁCOME, Fernanda Cunha et al. Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype. Pathogens, v. 10, 1084, 20 p, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49071
dc.identifier.issn.pt_BR.fl_str_mv 2076-7817
dc.identifier.doi.none.fl_str_mv 10.3390/pathogens10091084
identifier_str_mv JÁCOME, Fernanda Cunha et al. Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype. Pathogens, v. 10, 1084, 20 p, 2021.
2076-7817
10.3390/pathogens10091084
url https://www.arca.fiocruz.br/handle/icict/49071
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49071/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49071/2/AmandaPaulino_OrtrudBarth_etal_IOC_2021.pdf
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