Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.

Bibliographic Details
Main Author: Almeida, Marcos Célio de
Publication Date: 2003
Other Authors: Cardoso, Silvia Andrade, Barral Netto, Manoel
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/4163
Summary: Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
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spelling Almeida, Marcos Célio deCardoso, Silvia AndradeBarral Netto, Manoel2012-07-13T20:02:37Z2012-07-13T20:02:37Z2003DE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003.0020-7519doi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7https://www.arca.fiocruz.br/handle/icict/4163engLeishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2003Centro de Pesquisas Gonçalo MonizFundação Oswaldo CruzSalvadorUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.The initial steps of Leishmania infection in humans are largely unknown. There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules. We show here that Leishmania (L.) chagasi infection avoids inducing proinflammatory molecules and has striking down modulating effects on human monocytes or macrophages. It does not induce CD54, interleukin (IL)-12 or tumour necrosis factor-alpha, potent proinflammatory cytokines and down modulates CD11b expression in monocytes. Lipopolysaccharide stimulated IL-12 (p40) levels, CD54 and HLA-DR expression are diminished in infected monocytes as well as interferon-gamma stimulated HLA-DR and HLA-ABC expression in infected macrophages. There is a negative correlation between CD54 and CD86 expression in both monocytes and macrophages. The depressed expression of class I and II molecules, absence of key proinflammatory cytokines and impaired expression of costimulatory molecules induced by L. chagasi could leave the immune system, at least in its initial phases in anergy or ignorance.CostimulationCD54CD11bCD86CytokinesLeishmaniaAntígenos CD80/metabolismoLeishmania infantum/patogenicidadeLeishmaniose Visceral/imunologiaLeishmaniose Visceral/parasitologiaMacrófagos/parasitologiaMonócitos/parasitologiaAntígenos CD/imunologiaAntígenos CD11b/imunologiaAntígenos CD86Adesão CelularCélulas CultivadasCitocinas/imunologiaRegulação para BaixoCitometria de FluxoAntígenos HLA/imunologiaMolécula 1 de Adesão Intercelular/imunologiaInterferon gama/farmacologiaLipopolissacarídeos/farmacologiaAtivação LinfocitáriaMacrófagos/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDe Almeida MC Leishmania (Leishmania) chagasi....pdfDe Almeida MC Leishmania (Leishmania) chagasi....pdfapplication/pdf428562https://www.arca.fiocruz.br/bitstream/icict/4163/1/De%20Almeida%20MC%20Leishmania%20%28Leishmania%29%20chagasi....pdf5eaf85863df4c9eefab0050e225818fcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81990https://www.arca.fiocruz.br/bitstream/icict/4163/2/license.txtb6ead4607e393dee1190c21ba08397beMD52TEXTDe Almeida MC Leishmania (Leishmania) chagasi....pdf.txtDe Almeida MC Leishmania (Leishmania) chagasi....pdf.txtExtracted texttext/plain43680https://www.arca.fiocruz.br/bitstream/icict/4163/5/De%20Almeida%20MC%20Leishmania%20%28Leishmania%29%20chagasi....pdf.txt570a0ac54034e3f27e1b6ce1764c8270MD55THUMBNAILDe Almeida MC Leishmania (Leishmania) chagasi....pdf.jpgDe Almeida MC Leishmania (Leishmania) chagasi....pdf.jpgGenerated Thumbnailimage/jpeg2365https://www.arca.fiocruz.br/bitstream/icict/4163/4/De%20Almeida%20MC%20Leishmania%20%28Leishmania%29%20chagasi....pdf.jpg812759c6fe444109266660244ae2b236MD54icict/41632023-03-15 14:32:59.517oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
dc.title.original.pt_BR.fl_str_mv Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
title Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
spellingShingle Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
Almeida, Marcos Célio de
Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
Antígenos CD80/metabolismo
Leishmania infantum/patogenicidade
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/parasitologia
Macrófagos/parasitologia
Monócitos/parasitologia
Antígenos CD/imunologia
Antígenos CD11b/imunologia
Antígenos CD86
Adesão Celular
Células Cultivadas
Citocinas/imunologia
Regulação para Baixo
Citometria de Fluxo
Antígenos HLA/imunologia
Molécula 1 de Adesão Intercelular/imunologia
Interferon gama/farmacologia
Lipopolissacarídeos/farmacologia
Ativação Linfocitária
Macrófagos/imunologia
title_short Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
title_full Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
title_fullStr Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
title_full_unstemmed Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
title_sort Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage.
author Almeida, Marcos Célio de
author_facet Almeida, Marcos Célio de
Cardoso, Silvia Andrade
Barral Netto, Manoel
author_role author
author2 Cardoso, Silvia Andrade
Barral Netto, Manoel
author2_role author
author
dc.contributor.author.fl_str_mv Almeida, Marcos Célio de
Cardoso, Silvia Andrade
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
topic Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
Antígenos CD80/metabolismo
Leishmania infantum/patogenicidade
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/parasitologia
Macrófagos/parasitologia
Monócitos/parasitologia
Antígenos CD/imunologia
Antígenos CD11b/imunologia
Antígenos CD86
Adesão Celular
Células Cultivadas
Citocinas/imunologia
Regulação para Baixo
Citometria de Fluxo
Antígenos HLA/imunologia
Molécula 1 de Adesão Intercelular/imunologia
Interferon gama/farmacologia
Lipopolissacarídeos/farmacologia
Ativação Linfocitária
Macrófagos/imunologia
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD80/metabolismo
Leishmania infantum/patogenicidade
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/parasitologia
Macrófagos/parasitologia
Monócitos/parasitologia
Antígenos CD/imunologia
Antígenos CD11b/imunologia
Antígenos CD86
Adesão Celular
Células Cultivadas
Citocinas/imunologia
Regulação para Baixo
Citometria de Fluxo
Antígenos HLA/imunologia
Molécula 1 de Adesão Intercelular/imunologia
Interferon gama/farmacologia
Lipopolissacarídeos/farmacologia
Ativação Linfocitária
Macrófagos/imunologia
description Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2012-07-13T20:02:37Z
dc.date.available.fl_str_mv 2012-07-13T20:02:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4163
dc.identifier.issn.none.fl_str_mv 0020-7519
doi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7
identifier_str_mv DE ALMEIDA, M.C.; CARDOSO, S.A.; BARRAL-NETTO, M. Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage. International Journal of Parasitology, v. 33, n. 2, p. 153-62, feb. 2003.
0020-7519
doi:10 . 10 1 6/S0 0 20 -7 51 9 (0 2) 00 2 66 -7
url https://www.arca.fiocruz.br/handle/icict/4163
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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