Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review

Detalhes bibliográficos
Autor(a) principal: Counotte, Michel Jacques
Data de Publicação: 2019
Outros Autores: Meili, Kaspar Walter, Taghavi, Katayoun, Calvet, Guilherme, Sejvar, James, Low, Nicola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37961
Resumo: University Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.
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spelling Counotte, Michel JacquesMeili, Kaspar WalterTaghavi, KatayounCalvet, GuilhermeSejvar, JamesLow, Nicola2019-12-16T13:04:23Z2019-12-16T13:04:23Z2019COUNOTTE, Michel Jacques et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review [version 1; peer review: 2 approved]. F1000Research, v. 8, p. 1-22, 2019.2046-1402https://www.arca.fiocruz.br/handle/icict/3796110.12688/f1000research.19918.12046-1402engF1000ResearchZika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.University Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.University Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Centers for Disease Control and Prevention. National Center for Emerging and Zoonotic Infectious Diseases. Division of High-Consequence Pathogens and Pathology. Atlanta, GA, USA.University Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I 2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I 2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I 2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I 2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I 2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.ZikaDisease outbreaksArbovirusesCausalityGuillain-Barré syndromeCongenital abnormalitiesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/37961/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Counotte_Michel_etal_INI_2019.pdfve_Counotte_Michel_etal_INI_2019.pdfapplication/pdf2961467https://www.arca.fiocruz.br/bitstream/icict/37961/2/ve_Counotte_Michel_etal_INI_2019.pdf21c3028899e59cd3c1c204f12f876cbaMD52TEXTve_Counotte_Michel_etal_INI_2019.pdf.txtve_Counotte_Michel_etal_INI_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
title Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
spellingShingle Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
Counotte, Michel Jacques
Zika
Disease outbreaks
Arboviruses
Causality
Guillain-Barré syndrome
Congenital abnormalities
title_short Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
title_full Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
title_fullStr Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
title_full_unstemmed Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
title_sort Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review
author Counotte, Michel Jacques
author_facet Counotte, Michel Jacques
Meili, Kaspar Walter
Taghavi, Katayoun
Calvet, Guilherme
Sejvar, James
Low, Nicola
author_role author
author2 Meili, Kaspar Walter
Taghavi, Katayoun
Calvet, Guilherme
Sejvar, James
Low, Nicola
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Counotte, Michel Jacques
Meili, Kaspar Walter
Taghavi, Katayoun
Calvet, Guilherme
Sejvar, James
Low, Nicola
dc.subject.en.pt_BR.fl_str_mv Zika
Disease outbreaks
Arboviruses
Causality
Guillain-Barré syndrome
Congenital abnormalities
topic Zika
Disease outbreaks
Arboviruses
Causality
Guillain-Barré syndrome
Congenital abnormalities
description University Bern. Institute of Social and Preventive Medicine. Bern, Switzerland.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-12-16T13:04:23Z
dc.date.available.fl_str_mv 2019-12-16T13:04:23Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COUNOTTE, Michel Jacques et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review [version 1; peer review: 2 approved]. F1000Research, v. 8, p. 1-22, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37961
dc.identifier.issn.pt_BR.fl_str_mv 2046-1402
dc.identifier.doi.none.fl_str_mv 10.12688/f1000research.19918.1
dc.identifier.eissn.none.fl_str_mv 2046-1402
identifier_str_mv COUNOTTE, Michel Jacques et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: a living systematic review [version 1; peer review: 2 approved]. F1000Research, v. 8, p. 1-22, 2019.
2046-1402
10.12688/f1000research.19918.1
url https://www.arca.fiocruz.br/handle/icict/37961
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv F1000Research
publisher.none.fl_str_mv F1000Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/37961/2/ve_Counotte_Michel_etal_INI_2019.pdf
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