Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Fernandes, Erica de Souza; Lorena, Virgínia Maria de Barros; Sales, Iana Rafaela Fernandes; Albuquerque, Mônica Camelo Pessoa de Azevedo; Gomes, Yara de Miranda; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Detalhes bibliográficos
Autor(a) principal:	Fernandes, Erica de Souza
Data de Publicação:	2018
Outros Autores:	Lorena, Virgínia Maria de Barros, Sales, Iana Rafaela Fernandes, Albuquerque, Mônica Camelo Pessoa de Azevedo, Gomes, Yara de Miranda, Costa, Vlaudia Maria Assis, Souza, Valdênia Maria Oliveira de
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/32517
Resumo:	Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.

Metadados do item

id	CRUZ_eb04be16850f02280ad2779117802c31
oai_identifier_str	oai:www.arca.fiocruz.br:icict/32517
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Fernandes, Erica de SouzaLorena, Virgínia Maria de BarrosSales, Iana Rafaela FernandesAlbuquerque, Mônica Camelo Pessoa de AzevedoGomes, Yara de MirandaCosta, Vlaudia Maria AssisSouza, Valdênia Maria Oliveira de2019-04-16T14:19:17Z2019-04-16T14:19:17Z2018FERNANDES, E. de S. et al. Maternal Schistosomiasis: IL-2, IL-10 and Regulatory T Lymphocytes to Unrelated Antigen in Adult Offspring Mice. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 546–549, ago. 2018.1678-9849https://www.arca.fiocruz.br/handle/icict/3251710.1590/0037-8682-0338-2016engMaternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Medicina Tropical. Recife, PE, Brasil. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Medicina Tropical. Recife, PE, Brasil. Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil.INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.Maternal schistosomiasisAdult offspringImmunomodulationAnimaisAnimais, amamentação / imunologiaAnimais, mamando / parasitologiaAnticorpos, Helmintos / imunologiaFêmeaCitometria de FluxoInterleucina-10 / imunologiaInterleucina-2 / imunologiaRatosOvalbumina / imunologiaGravidezEsquistossomose mansoni / imunologiaLinfócitos T, Regulatórios / imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/32517/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALMaternal schistosomias.pdfMaternal schistosomias.pdfapplication/pdf1018997https://www.arca.fiocruz.br/bitstream/icict/32517/2/Maternal%20schistosomias.pdfc1ec1c407e05afe150263743a6abdda8MD52TEXTMaternal schistosomias.pdf.txtMaternal schistosomias.pdf.txtExtracted texttext/plain16168https://www.arca.fiocruz.br/bitstream/icict/32517/3/Maternal%20schistosomias.pdf.txt4a882339ffa94f27d4171694439d4d7cMD53icict/325172019-04-17 17:22:22.735oai:www.arca.fiocruz.br:icict/32517Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpBbmEgQmVhdHJpeiBPbGl2ZWlyYSwgQ1BGOiAxMjIuNjk3LjU3NC03NSwgdmluY3VsYWRvIGEgQ1BxQU0gLSBDZW50cm8gZGUgUGVzcXVpc2FzIEFnZ2V1IE1hZ2FsaMOjZXMKCkFvIGFjZWl0YXIgb3MgVEVSTU9TIGUgQ09OREnDh8OVRVMgZGVzdGEgQ0VTU8ODTywgbyBBVVRPUiBlL291IFRJVFVMQVIgZGUgZGlyZWl0b3MKYXV0b3JhaXMgc29icmUgYSBPQlJBIGRlIHF1ZSB0cmF0YSBlc3RlIGRvY3VtZW50bzoKCigxKSBDRURFIGUgVFJBTlNGRVJFLCB0b3RhbCBlIGdyYXR1aXRhbWVudGUsIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiwgZW0KY2Fyw6F0ZXIgcGVybWFuZW50ZSwgaXJyZXZvZ8OhdmVsIGUgTsODTyBFWENMVVNJVk8sIHRvZG9zIG9zIGRpcmVpdG9zIHBhdHJpbW9uaWFpcyBOw4NPCkNPTUVSQ0lBSVMgZGUgdXRpbGl6YcOnw6NvIGRhIE9CUkEgYXJ0w61zdGljYSBlL291IGNpZW50w61maWNhIGluZGljYWRhIGFjaW1hLCBpbmNsdXNpdmUgb3MgZGlyZWl0b3MKZGUgdm96IGUgaW1hZ2VtIHZpbmN1bGFkb3Mgw6AgT0JSQSwgZHVyYW50ZSB0b2RvIG8gcHJhem8gZGUgZHVyYcOnw6NvIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgZW0KcXVhbHF1ZXIgaWRpb21hIGUgZW0gdG9kb3Mgb3MgcGHDrXNlczsKCigyKSBBQ0VJVEEgcXVlIGEgY2Vzc8OjbyB0b3RhbCBuw6NvIGV4Y2x1c2l2YSwgcGVybWFuZW50ZSBlIGlycmV2b2fDoXZlbCBkb3MgZGlyZWl0b3MgYXV0b3JhaXMKcGF0cmltb25pYWlzIG7Do28gY29tZXJjaWFpcyBkZSB1dGlsaXphw6fDo28gZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvIGluY2x1aSwgZXhlbXBsaWZpY2F0aXZhbWVudGUsCm9zIGRpcmVpdG9zIGRlIGRpc3BvbmliaWxpemHDp8OjbyBlIGNvbXVuaWNhw6fDo28gcMO6YmxpY2EgZGEgT0JSQSwgZW0gcXVhbHF1ZXIgbWVpbyBvdSB2ZcOtY3VsbywKaW5jbHVzaXZlIGVtIFJlcG9zaXTDs3Jpb3MgRGlnaXRhaXMsIGJlbSBjb21vIG9zIGRpcmVpdG9zIGRlIHJlcHJvZHXDp8OjbywgZXhpYmnDp8OjbywgZXhlY3XDp8OjbywKZGVjbGFtYcOnw6NvLCByZWNpdGHDp8OjbywgZXhwb3Npw6fDo28sIGFycXVpdmFtZW50bywgaW5jbHVzw6NvIGVtIGJhbmNvIGRlIGRhZG9zLCBwcmVzZXJ2YcOnw6NvLCBkaWZ1c8OjbywKZGlzdHJpYnVpw6fDo28sIGRpdnVsZ2HDp8OjbywgZW1wcsOpc3RpbW8sIHRyYWR1w6fDo28sIGR1YmxhZ2VtLCBsZWdlbmRhZ2VtLCBpbmNsdXPDo28gZW0gbm92YXMgb2JyYXMgb3UKY29sZXTDom5lYXMsIHJldXRpbGl6YcOnw6NvLCBlZGnDp8OjbywgcHJvZHXDp8OjbyBkZSBtYXRlcmlhbCBkaWTDoXRpY28gZSBjdXJzb3Mgb3UgcXVhbHF1ZXIgZm9ybWEgZGUKdXRpbGl6YcOnw6NvIG7Do28gY29tZXJjaWFsOwoKKDMpIFJFQ09OSEVDRSBxdWUgYSBjZXNzw6NvIGFxdWkgZXNwZWNpZmljYWRhIGNvbmNlZGUgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETwpDUlVaIG8gZGlyZWl0byBkZSBhdXRvcml6YXIgcXVhbHF1ZXIgcGVzc29hIOKAkyBmw61zaWNhIG91IGp1csOtZGljYSwgcMO6YmxpY2Egb3UgcHJpdmFkYSwgbmFjaW9uYWwgb3UKZXN0cmFuZ2VpcmEg4oCTIGEgYWNlc3NhciBlIHV0aWxpemFyIGFtcGxhbWVudGUgYSBPQlJBLCBzZW0gZXhjbHVzaXZpZGFkZSwgcGFyYSBxdWFpc3F1ZXIKZmluYWxpZGFkZXMgbsOjbyBjb21lcmNpYWlzOwoKKDQpIERFQ0xBUkEgcXVlIGEgb2JyYSDDqSBjcmlhw6fDo28gb3JpZ2luYWwgZSBxdWUgw6kgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBhcXVpIGNlZGlkb3MgZSBhdXRvcml6YWRvcywKcmVzcG9uc2FiaWxpemFuZG8tc2UgaW50ZWdyYWxtZW50ZSBwZWxvIGNvbnRlw7pkbyBlIG91dHJvcyBlbGVtZW50b3MgcXVlIGZhemVtIHBhcnRlIGRhIE9CUkEsCmluY2x1c2l2ZSBvcyBkaXJlaXRvcyBkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBvYnJpZ2FuZG8tc2UgYSBpbmRlbml6YXIgdGVyY2Vpcm9zIHBvcgpkYW5vcywgYmVtIGNvbW8gaW5kZW5pemFyIGUgcmVzc2FyY2lyIGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIGRlCmV2ZW50dWFpcyBkZXNwZXNhcyBxdWUgdmllcmVtIGEgc3Vwb3J0YXIsIGVtIHJhesOjbyBkZSBxdWFscXVlciBvZmVuc2EgYSBkaXJlaXRvcyBhdXRvcmFpcyBvdQpkaXJlaXRvcyBkZSB2b3ogb3UgaW1hZ2VtLCBwcmluY2lwYWxtZW50ZSBubyBxdWUgZGl6IHJlc3BlaXRvIGEgcGzDoWdpbyBlIHZpb2xhw6fDtWVzIGRlIGRpcmVpdG9zOwoKKDUpIEFGSVJNQSBxdWUgY29uaGVjZSBhIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08KT1NXQUxETyBDUlVaIGUgYXMgZGlyZXRyaXplcyBwYXJhIG8gZnVuY2lvbmFtZW50byBkbyByZXBvc2l0w7NyaW8gaW5zdGl0dWNpb25hbCBBUkNBLgoKQSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiByZXNlcnZhCmV4Y2x1c2l2YW1lbnRlIGFvIEFVVE9SIG9zIGRpcmVpdG9zIG1vcmFpcyBlIG9zIHVzb3MgY29tZXJjaWFpcyBzb2JyZSBhcyBvYnJhcyBkZSBzdWEgYXV0b3JpYQplL291IHRpdHVsYXJpZGFkZSwgc2VuZG8gb3MgdGVyY2Vpcm9zIHVzdcOhcmlvcyByZXNwb25zw6F2ZWlzIHBlbGEgYXRyaWJ1acOnw6NvIGRlIGF1dG9yaWEgZSBtYW51dGVuw6fDo28KZGEgaW50ZWdyaWRhZGUgZGEgT0JSQSBlbSBxdWFscXVlciB1dGlsaXphw6fDo28uCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaCnJlc3BlaXRhIG9zIGNvbnRyYXRvcyBlIGFjb3Jkb3MgcHJlZXhpc3RlbnRlcyBkb3MgQXV0b3JlcyBjb20gdGVyY2Vpcm9zLCBjYWJlbmRvIGFvcyBBdXRvcmVzCmluZm9ybWFyIMOgIEluc3RpdHVpw6fDo28gYXMgY29uZGnDp8O1ZXMgZSBvdXRyYXMgcmVzdHJpw6fDtWVzIGltcG9zdGFzIHBvciBlc3RlcyBpbnN0cnVtZW50b3MuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-17T20:22:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
title	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
spellingShingle	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice Fernandes, Erica de Souza Maternal schistosomiasis Adult offspring Immunomodulation Animais Animais, amamentação / imunologia Animais, mamando / parasitologia Anticorpos, Helmintos / imunologia Fêmea Citometria de Fluxo Interleucina-10 / imunologia Interleucina-2 / imunologia Ratos Ovalbumina / imunologia Gravidez Esquistossomose mansoni / imunologia Linfócitos T, Regulatórios / imunologia
title_short	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
title_full	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
title_fullStr	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
title_full_unstemmed	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
title_sort	Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
author	Fernandes, Erica de Souza
author_facet	Fernandes, Erica de Souza Lorena, Virgínia Maria de Barros Sales, Iana Rafaela Fernandes Albuquerque, Mônica Camelo Pessoa de Azevedo Gomes, Yara de Miranda Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de
author_role	author
author2	Lorena, Virgínia Maria de Barros Sales, Iana Rafaela Fernandes Albuquerque, Mônica Camelo Pessoa de Azevedo Gomes, Yara de Miranda Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de
author2_role	author author author author author author
dc.contributor.author.fl_str_mv	Fernandes, Erica de Souza Lorena, Virgínia Maria de Barros Sales, Iana Rafaela Fernandes Albuquerque, Mônica Camelo Pessoa de Azevedo Gomes, Yara de Miranda Costa, Vlaudia Maria Assis Souza, Valdênia Maria Oliveira de
dc.subject.en.pt_BR.fl_str_mv	Maternal schistosomiasis Adult offspring Immunomodulation
topic	Maternal schistosomiasis Adult offspring Immunomodulation Animais Animais, amamentação / imunologia Animais, mamando / parasitologia Anticorpos, Helmintos / imunologia Fêmea Citometria de Fluxo Interleucina-10 / imunologia Interleucina-2 / imunologia Ratos Ovalbumina / imunologia Gravidez Esquistossomose mansoni / imunologia Linfócitos T, Regulatórios / imunologia
dc.subject.decs.pt_BR.fl_str_mv	Animais Animais, amamentação / imunologia Animais, mamando / parasitologia Anticorpos, Helmintos / imunologia Fêmea Citometria de Fluxo Interleucina-10 / imunologia Interleucina-2 / imunologia Ratos Ovalbumina / imunologia Gravidez Esquistossomose mansoni / imunologia Linfócitos T, Regulatórios / imunologia
description	Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.
publishDate	2018
dc.date.issued.fl_str_mv	2018
dc.date.accessioned.fl_str_mv	2019-04-16T14:19:17Z
dc.date.available.fl_str_mv	2019-04-16T14:19:17Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FERNANDES, E. de S. et al. Maternal Schistosomiasis: IL-2, IL-10 and Regulatory T Lymphocytes to Unrelated Antigen in Adult Offspring Mice. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 546–549, ago. 2018.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/32517
dc.identifier.issn.pt_BR.fl_str_mv	1678-9849
dc.identifier.doi.none.fl_str_mv	10.1590/0037-8682-0338-2016
identifier_str_mv	FERNANDES, E. de S. et al. Maternal Schistosomiasis: IL-2, IL-10 and Regulatory T Lymphocytes to Unrelated Antigen in Adult Offspring Mice. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 546–549, ago. 2018. 1678-9849 10.1590/0037-8682-0338-2016
url	https://www.arca.fiocruz.br/handle/icict/32517
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/32517/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/32517/2/Maternal%20schistosomias.pdf https://www.arca.fiocruz.br/bitstream/icict/32517/3/Maternal%20schistosomias.pdf.txt
bitstream.checksum.fl_str_mv	ee3692f7b0b97d5638099ab94397d05f c1ec1c407e05afe150263743a6abdda8 4a882339ffa94f27d4171694439d4d7c
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798324759453237248

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Registros relacionados