Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43906 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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Bozza, Patrícia T.Yu, WenguiWeller, Peter F.2020-10-09T17:35:04Z2020-10-09T17:35:04Z1997BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/4390610.1590/S0074-027619970008000181678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.EosinophilsCorpos lipídicosEicosanoidesInflamaçãoLipid bodiesEosinophilsEicosanoidsInflammationMechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Harvard Thorndike Laboratory and Charles A. Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School. Boston, MA, USA.Harvard Thorndike Laboratory and Charles A. Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School. Boston, MA, USA.Lipid bodies, inducible lipid-rich cytoplasmic inclusions, are characteristically abundant in cells associated with inflammation, including eosinophils. Here we reviewed the formation and function of lipid bodies in human eosinophils. We now have evidence that the formation of lipid bodies is not attributable to adverse mechanisms, but is centrally mediated by specific signal transduction pathways. Arachidonic acid and other cis fatty acids by an NSAID-inhibitable process, diglycerides, and PAF by a 5-lipoxygenase dependent pathway are potent stimulators of lipid body induction. Lipid body formation develops rapidly by processes that involve PKC, PLC, and de novo mRNA and protein synthesis. These structures clearly serve as repositoires of arachidonyl-phospholipids and are more than inert depots. Specific enzymes, including cytosolic phospholipase A2, MAP kinases, lipoxygenases and cyclooxygenases, associate with lipid bodies. Lipid bodies appear to be dynamic, organelle-like structures involved in intracellular pathways of lipid mobilization and metabolism. Indeed, increases in lipid body numbers correlated with enhanced production of both lipoxygenase- and cyclooxygenase-derived eicosanoids. We hypothesize that lipid bodies are distinct inducible sites for generating eicosanoids as paracrine mediators with varied activities in inflammation. The capacity of lipid body formation to be specifically and rapidly induced in leukocytes enhances eicosanoid mediator formation, and conversely pharmacologic inhibition of lipid body induction represents a potential novel and specific target for anti-inflammatory therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43906/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaT_Bozza_etal_IOC_1997.pdfPatriciaT_Bozza_etal_IOC_1997.pdfapplication/pdf79735https://www.arca.fiocruz.br/bitstream/icict/43906/2/PatriciaT_Bozza_etal_IOC_1997.pdf146e28420e875b8efd27bf63aff0f3c3MD52TEXTPatriciaT_Bozza_etal_IOC_1997.pdf.txtPatriciaT_Bozza_etal_IOC_1997.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
title |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
spellingShingle |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism Bozza, Patrícia T. Eosinophils Corpos lipídicos Eicosanoides Inflamação Lipid bodies Eosinophils Eicosanoids Inflammation |
title_short |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
title_full |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
title_fullStr |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
title_full_unstemmed |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
title_sort |
Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism |
author |
Bozza, Patrícia T. |
author_facet |
Bozza, Patrícia T. Yu, Wengui Weller, Peter F. |
author_role |
author |
author2 |
Yu, Wengui Weller, Peter F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Bozza, Patrícia T. Yu, Wengui Weller, Peter F. |
dc.subject.other.pt_BR.fl_str_mv |
Eosinophils Corpos lipídicos Eicosanoides Inflamação |
topic |
Eosinophils Corpos lipídicos Eicosanoides Inflamação Lipid bodies Eosinophils Eicosanoids Inflammation |
dc.subject.en.pt_BR.fl_str_mv |
Lipid bodies Eosinophils Eicosanoids Inflammation |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
1997 |
dc.date.issued.fl_str_mv |
1997 |
dc.date.accessioned.fl_str_mv |
2020-10-09T17:35:04Z |
dc.date.available.fl_str_mv |
2020-10-09T17:35:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/43906 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02761997000800018 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
BOZZA, Patricia T.; YU, Wengiu; WELLER, Peter F. Mechanisms of Formation and Function of Eosinophil Lipid Bodies: Inducible Intracellular Sites Involved in Arachidonic Acid Metabolism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p.135-140, 1997. 0074-0276 10.1590/S0074-02761997000800018 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/43906 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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