Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens

Detalhes bibliográficos
Autor(a) principal: Macedo, Gilson Costa
Data de Publicação: 2011
Outros Autores: Melo, Adriana Bozzi de, Weinreich, Helena Rachel, Bafica, Andre Luiz Barbosa, Teixeira, Henrique Couto, Oliveira, Sergio Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11668
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, Brazil
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spelling Macedo, Gilson CostaMelo, Adriana Bozzi deWeinreich, Helena RachelBafica, Andre Luiz BarbosaTeixeira, Henrique CoutoOliveira, Sergio Costa2015-09-02T18:07:40Z2015-09-02T18:07:40Z2011MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011.1365-2249https://www.arca.fiocruz.br/handle/icict/1166810.1155/2011/351573engWiley Online LibraryHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, BrazilUniversidade Federal de Juiz de Fora. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, BrazilTuberculosis remains a major health problem throughout the world causing large number of deaths. Effective disease control and eradication programs require the identification of major antigens recognized by the protective responses against M. tuberculosis. In this study, we have investigated humoral and cellular immune responses to M. tuberculosis-specific Ag85A, Ag85B, and ESAT-6 antigens in Brazilian patients with pulmonary (P, n = 13) or extrapulmonary (EP, n = 12) tuberculosis, patients undergoing chemotherapy (PT, n = 23), and noninfected healthy individuals (NI, n = 7). Compared to NI, we observed increased levels of IgG1 responses to Ag85B and ESAT-6 in P and PT groups. Regarding cellular immunity, Ag85A and ESAT-6 were able to discriminate P, PT, and EP patients from healthy individuals by IFN-γ production and P and PT groups from EP individuals by production of TNF-α. In summary, these findings demonstrate the ability of Ag85A, Ag85B, and ESAT-6 to differentiate TB patients from controls by IgG1, IFN-γ and TNF-α production.Tuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11668/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdfHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdfapplication/pdf5293021https://www.arca.fiocruz.br/bitstream/icict/11668/2/Human%20T-cell%20and%20antibody%20mediated%20responses%20to%20the%20Mycobacterium%20tuberculosis%20recombinant%2085A%2c%2085B%20and%20ESAT-6%20antigens.pdf2b102ed710e22b58583281d793cf3ac5MD52TEXTHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdf.txtHuman T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens.pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/11668/3/Human%20T-cell%20and%20antibody%20mediated%20responses%20to%20the%20Mycobacterium%20tuberculosis%20recombinant%2085A%2c%2085B%20and%20ESAT-6%20antigens.pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD53icict/116682019-06-19 10:05:25.688oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:05:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
title Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
spellingShingle Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
Macedo, Gilson Costa
Tuberculosis
title_short Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
title_full Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
title_fullStr Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
title_full_unstemmed Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
title_sort Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens
author Macedo, Gilson Costa
author_facet Macedo, Gilson Costa
Melo, Adriana Bozzi de
Weinreich, Helena Rachel
Bafica, Andre Luiz Barbosa
Teixeira, Henrique Couto
Oliveira, Sergio Costa
author_role author
author2 Melo, Adriana Bozzi de
Weinreich, Helena Rachel
Bafica, Andre Luiz Barbosa
Teixeira, Henrique Couto
Oliveira, Sergio Costa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo, Gilson Costa
Melo, Adriana Bozzi de
Weinreich, Helena Rachel
Bafica, Andre Luiz Barbosa
Teixeira, Henrique Couto
Oliveira, Sergio Costa
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
topic Tuberculosis
description Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Laboratorio de Imunologia e Doenças Infecciosas. Belo Horizonte, MG, Brazil/ Universidade Federal de Santa Catarina. Departamento de Parasitologia, Microbiologia e Imunologia. Florianopolis, SC, Brazil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2015-09-02T18:07:40Z
dc.date.available.fl_str_mv 2015-09-02T18:07:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11668
dc.identifier.issn.none.fl_str_mv 1365-2249
dc.identifier.doi.none.fl_str_mv 10.1155/2011/351573
identifier_str_mv MACEDO, Gilson Costa et al. Human T-cell and antibody mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B and ESAT-6 antigens. Clinical & Developmental Immunology, vol. 2011, ID 351573, 2011.
1365-2249
10.1155/2011/351573
url https://www.arca.fiocruz.br/handle/icict/11668
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Wiley Online Library
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