Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention

Detalhes bibliográficos
Autor(a) principal: Lockwood, Diana N.
Data de Publicação: 2018
Outros Autores: Krishnamurthy, Padebettu, Kumar, Bhushan, Penna, Gerson Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41150
Resumo: Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
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spelling Lockwood, Diana N.Krishnamurthy, PadebettuKumar, BhushanPenna, Gerson Oliveira2020-05-07T16:19:34Z2020-05-07T16:19:34Z2018LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/4115010.1371/journal.pntd.0006403Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.London School of Hygiene and Tropical Medicine. London, United Kingdom.Damien Foundation of India Trust. Chennai, India.Postgraduate Institute of Medical Education and Research. Department of Dermatology, STD and Leprosy. Chandigarh, India.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Brasília, DF, Brasil.Single-dose rifampicin (SDR) treatment being offered to household contacts of new leprosy patients is being practiced by the Indian National Leprosy Programme since November 2017. We are concerned, because this is not an effective method for preventing multibacillary (MB) leprosy. It does not protect against the development of MB leprosy and does not protect immediate household contacts for a reasonable period of time. There are serious ethical problems related to identifying the contacts of patients with leprosy, it is not cost effective for household contacts, and there is a possibility of the widespread use of SDR promoting the development of rifampicin resistance genes in Mycobacterium leprae.engPublic Library of ScienceChemopreventionCost-Benefit AnalysisFamily CharacteristicsLeprosy, MultibacillaryPreventive Health ServicesRifampinMycobacterium lepraeLeprosyRifampinCost-benefit analysisPreventive health servicesMycobacterium lepraeHanseníaseRifampinaAnálise custo-benefícioServiços Preventivos de SaúdeMycobacterium lepraeDoenças NegligenciadasDoenças TransmissíveisSingle-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective interventioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
title Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
spellingShingle Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
Lockwood, Diana N.
Chemoprevention
Cost-Benefit Analysis
Family Characteristics
Leprosy, Multibacillary
Preventive Health Services
Rifampin
Mycobacterium leprae
Leprosy
Rifampin
Cost-benefit analysis
Preventive health services
Mycobacterium leprae
Hanseníase
Rifampina
Análise custo-benefício
Serviços Preventivos de Saúde
Mycobacterium leprae
Doenças Negligenciadas
Doenças Transmissíveis
title_short Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
title_full Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
title_fullStr Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
title_full_unstemmed Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
title_sort Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
author Lockwood, Diana N.
author_facet Lockwood, Diana N.
Krishnamurthy, Padebettu
Kumar, Bhushan
Penna, Gerson Oliveira
author_role author
author2 Krishnamurthy, Padebettu
Kumar, Bhushan
Penna, Gerson Oliveira
author2_role author
author
author
dc.contributor.author.fl_str_mv Lockwood, Diana N.
Krishnamurthy, Padebettu
Kumar, Bhushan
Penna, Gerson Oliveira
dc.subject.mesh.pt_BR.fl_str_mv Chemoprevention
Cost-Benefit Analysis
Family Characteristics
Leprosy, Multibacillary
Preventive Health Services
Rifampin
Mycobacterium leprae
topic Chemoprevention
Cost-Benefit Analysis
Family Characteristics
Leprosy, Multibacillary
Preventive Health Services
Rifampin
Mycobacterium leprae
Leprosy
Rifampin
Cost-benefit analysis
Preventive health services
Mycobacterium leprae
Hanseníase
Rifampina
Análise custo-benefício
Serviços Preventivos de Saúde
Mycobacterium leprae
Doenças Negligenciadas
Doenças Transmissíveis
dc.subject.en.pt_BR.fl_str_mv Leprosy
Rifampin
Cost-benefit analysis
Preventive health services
Mycobacterium leprae
dc.subject.decs.pt_BR.fl_str_mv Hanseníase
Rifampina
Análise custo-benefício
Serviços Preventivos de Saúde
Mycobacterium leprae
Doenças Negligenciadas
Doenças Transmissíveis
description Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-05-07T16:19:34Z
dc.date.available.fl_str_mv 2020-05-07T16:19:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41150
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0006403
identifier_str_mv LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018.
1935-2727
10.1371/journal.pntd.0006403
url https://www.arca.fiocruz.br/handle/icict/41150
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/41150/2/ve_Diana_Lockwood_etal.pdf
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