Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41150 |
Resumo: | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Lockwood, Diana N.Krishnamurthy, PadebettuKumar, BhushanPenna, Gerson Oliveira2020-05-07T16:19:34Z2020-05-07T16:19:34Z2018LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/4115010.1371/journal.pntd.0006403Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.London School of Hygiene and Tropical Medicine. London, United Kingdom.Damien Foundation of India Trust. Chennai, India.Postgraduate Institute of Medical Education and Research. Department of Dermatology, STD and Leprosy. Chandigarh, India.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Brasília, DF, Brasil.Single-dose rifampicin (SDR) treatment being offered to household contacts of new leprosy patients is being practiced by the Indian National Leprosy Programme since November 2017. We are concerned, because this is not an effective method for preventing multibacillary (MB) leprosy. It does not protect against the development of MB leprosy and does not protect immediate household contacts for a reasonable period of time. There are serious ethical problems related to identifying the contacts of patients with leprosy, it is not cost effective for household contacts, and there is a possibility of the widespread use of SDR promoting the development of rifampicin resistance genes in Mycobacterium leprae.engPublic Library of ScienceChemopreventionCost-Benefit AnalysisFamily CharacteristicsLeprosy, MultibacillaryPreventive Health ServicesRifampinMycobacterium lepraeLeprosyRifampinCost-benefit analysisPreventive health servicesMycobacterium lepraeHanseníaseRifampinaAnálise custo-benefícioServiços Preventivos de SaúdeMycobacterium lepraeDoenças NegligenciadasDoenças TransmissíveisSingle-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective interventioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
title |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
spellingShingle |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention Lockwood, Diana N. Chemoprevention Cost-Benefit Analysis Family Characteristics Leprosy, Multibacillary Preventive Health Services Rifampin Mycobacterium leprae Leprosy Rifampin Cost-benefit analysis Preventive health services Mycobacterium leprae Hanseníase Rifampina Análise custo-benefício Serviços Preventivos de Saúde Mycobacterium leprae Doenças Negligenciadas Doenças Transmissíveis |
title_short |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
title_full |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
title_fullStr |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
title_full_unstemmed |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
title_sort |
Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention |
author |
Lockwood, Diana N. |
author_facet |
Lockwood, Diana N. Krishnamurthy, Padebettu Kumar, Bhushan Penna, Gerson Oliveira |
author_role |
author |
author2 |
Krishnamurthy, Padebettu Kumar, Bhushan Penna, Gerson Oliveira |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lockwood, Diana N. Krishnamurthy, Padebettu Kumar, Bhushan Penna, Gerson Oliveira |
dc.subject.mesh.pt_BR.fl_str_mv |
Chemoprevention Cost-Benefit Analysis Family Characteristics Leprosy, Multibacillary Preventive Health Services Rifampin Mycobacterium leprae |
topic |
Chemoprevention Cost-Benefit Analysis Family Characteristics Leprosy, Multibacillary Preventive Health Services Rifampin Mycobacterium leprae Leprosy Rifampin Cost-benefit analysis Preventive health services Mycobacterium leprae Hanseníase Rifampina Análise custo-benefício Serviços Preventivos de Saúde Mycobacterium leprae Doenças Negligenciadas Doenças Transmissíveis |
dc.subject.en.pt_BR.fl_str_mv |
Leprosy Rifampin Cost-benefit analysis Preventive health services Mycobacterium leprae |
dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Rifampina Análise custo-benefício Serviços Preventivos de Saúde Mycobacterium leprae Doenças Negligenciadas Doenças Transmissíveis |
description |
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-05-07T16:19:34Z |
dc.date.available.fl_str_mv |
2020-05-07T16:19:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41150 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0006403 |
identifier_str_mv |
LOCKWOOD, Diana N. J. et al. Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. PLOS Neglected Tropical Diseases, [San Francisco], v. 12, n. 6, p. 1-4, jun. 2018. 1935-2727 10.1371/journal.pntd.0006403 |
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https://www.arca.fiocruz.br/handle/icict/41150 |
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eng |
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eng |
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Public Library of Science |
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