The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review

Detalhes bibliográficos
Autor(a) principal: Grimaldi Jr., Gabriel
Data de Publicação: 2008
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19317
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil.
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spelling Grimaldi Jr., Gabriel2017-06-06T13:59:25Z2017-06-06T13:59:25Z2008GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/1931710.1590/S0074-027620080007000021678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzPrimatas não-humanosDesenvolvimento da vacina LeishmaniaLeishmaniose experimentalexperimental leishmaniasisLeishmania vaccine developmentnon-human primatesThe utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil.Leishmaniasis causes significant morbidity and mortality, constituting an important global health problem for which there are few effective drugs. Given the urgent need to identify a safe and effective Leishmania vaccine to help prevent the two million new cases of human leishmaniasis worldwide each year, all reasonable efforts to achieve this goal should be made. This includes the use of animal models that are as close to leishmanial infection in humans as is practical and feasible. Old world monkey species (macaques, baboons, mandrills etc.) have the closest evolutionary relatedness to humans among the approachable animal models. The Asian rhesus macaques (Macaca mulatta) are quite susceptible to leishmanial infection, develop a human-like disease, exhibit antibodies to Leishmania and parasite-specific T-cell mediated immune responses both in vivo and in vitro, and can be protected effectively by vaccination. Results from macaque vaccine studies could also prove useful in guiding the design of human vaccine trials. This review summarizes our current knowledge on this topic and proposes potential approaches that may result in the more effective use of the macaque model to maximize its potential to help the development of an effective vaccine for human leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19317/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgabriel_grimaldijr2_IOC_2008.pdfgabriel_grimaldijr2_IOC_2008.pdfapplication/pdf709381https://www.arca.fiocruz.br/bitstream/icict/19317/2/gabriel_grimaldijr2_IOC_2008.pdfe867703bdc0cf8797a6da7f4cd417ef7MD52TEXTgabriel_grimaldijr2_IOC_2008.pdf.txtgabriel_grimaldijr2_IOC_2008.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
title The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
spellingShingle The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
Grimaldi Jr., Gabriel
Primatas não-humanos
Desenvolvimento da vacina Leishmania
Leishmaniose experimental
experimental leishmaniasis
Leishmania vaccine development
non-human primates
title_short The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
title_full The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
title_fullStr The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
title_full_unstemmed The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
title_sort The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
author Grimaldi Jr., Gabriel
author_facet Grimaldi Jr., Gabriel
author_role author
dc.contributor.author.fl_str_mv Grimaldi Jr., Gabriel
dc.subject.other.pt_BR.fl_str_mv Primatas não-humanos
Desenvolvimento da vacina Leishmania
Leishmaniose experimental
topic Primatas não-humanos
Desenvolvimento da vacina Leishmania
Leishmaniose experimental
experimental leishmaniasis
Leishmania vaccine development
non-human primates
dc.subject.en.pt_BR.fl_str_mv experimental leishmaniasis
Leishmania vaccine development
non-human primates
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2017-06-06T13:59:25Z
dc.date.available.fl_str_mv 2017-06-06T13:59:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19317
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762008000700002
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008.
0074-0276
10.1590/S0074-02762008000700002
1678-8060
url https://www.arca.fiocruz.br/handle/icict/19317
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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