The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19317 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil. |
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Grimaldi Jr., Gabriel2017-06-06T13:59:25Z2017-06-06T13:59:25Z2008GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/1931710.1590/S0074-027620080007000021678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzPrimatas não-humanosDesenvolvimento da vacina LeishmaniaLeishmaniose experimentalexperimental leishmaniasisLeishmania vaccine developmentnon-human primatesThe utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil.Leishmaniasis causes significant morbidity and mortality, constituting an important global health problem for which there are few effective drugs. Given the urgent need to identify a safe and effective Leishmania vaccine to help prevent the two million new cases of human leishmaniasis worldwide each year, all reasonable efforts to achieve this goal should be made. This includes the use of animal models that are as close to leishmanial infection in humans as is practical and feasible. Old world monkey species (macaques, baboons, mandrills etc.) have the closest evolutionary relatedness to humans among the approachable animal models. The Asian rhesus macaques (Macaca mulatta) are quite susceptible to leishmanial infection, develop a human-like disease, exhibit antibodies to Leishmania and parasite-specific T-cell mediated immune responses both in vivo and in vitro, and can be protected effectively by vaccination. Results from macaque vaccine studies could also prove useful in guiding the design of human vaccine trials. This review summarizes our current knowledge on this topic and proposes potential approaches that may result in the more effective use of the macaque model to maximize its potential to help the development of an effective vaccine for human leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19317/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgabriel_grimaldijr2_IOC_2008.pdfgabriel_grimaldijr2_IOC_2008.pdfapplication/pdf709381https://www.arca.fiocruz.br/bitstream/icict/19317/2/gabriel_grimaldijr2_IOC_2008.pdfe867703bdc0cf8797a6da7f4cd417ef7MD52TEXTgabriel_grimaldijr2_IOC_2008.pdf.txtgabriel_grimaldijr2_IOC_2008.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
title |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
spellingShingle |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review Grimaldi Jr., Gabriel Primatas não-humanos Desenvolvimento da vacina Leishmania Leishmaniose experimental experimental leishmaniasis Leishmania vaccine development non-human primates |
title_short |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
title_full |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
title_fullStr |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
title_full_unstemmed |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
title_sort |
The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review |
author |
Grimaldi Jr., Gabriel |
author_facet |
Grimaldi Jr., Gabriel |
author_role |
author |
dc.contributor.author.fl_str_mv |
Grimaldi Jr., Gabriel |
dc.subject.other.pt_BR.fl_str_mv |
Primatas não-humanos Desenvolvimento da vacina Leishmania Leishmaniose experimental |
topic |
Primatas não-humanos Desenvolvimento da vacina Leishmania Leishmaniose experimental experimental leishmaniasis Leishmania vaccine development non-human primates |
dc.subject.en.pt_BR.fl_str_mv |
experimental leishmaniasis Leishmania vaccine development non-human primates |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ. Brasil. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2017-06-06T13:59:25Z |
dc.date.available.fl_str_mv |
2017-06-06T13:59:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19317 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762008000700002 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
GRIMALDI JR., Gabriel. The utility of rhesus monkey (Macaca mulatta) and other non-human primate models for preclinical testing of Leishmania candidate vaccines - a review. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.629-644. 2008. 0074-0276 10.1590/S0074-02762008000700002 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/19317 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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