Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19308 |
Resumo: | Artur Trancoso Lopo de Queiroz “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
| id |
CRUZ_fa7f822146925308775137801d7475f8 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/19308 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Bittar, CíntiaJardim, Ana Carolina GomesYamasaki, Lilian Hiromi Tomonari YamasakiQueiróz, Artur Trancoso Lopo deCarareto, Claudia Maria AparecidaPinho, João Renato RebelloMello, Isabel Maria Vicente Guedes de CarvalhoRahal, Paula2017-06-06T12:26:18Z2017-06-06T12:26:18Z2010BITTAR, C. et al. Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response. BMC Infectious Diseases, v. 10, p. 36, 20101471-2334https://www.arca.fiocruz.br/handle/icict/1930810.1186/1471-2334-10-36Artur Trancoso Lopo de Queiroz “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.FAPESP and CAPES.São Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, BrasilSão Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, BrasilSão Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, BrasilSão Paulo University. São Paulo, SP, BrazilSão Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, BrasilSão Paulo University. Faculty of Medicine. Institute of Tropical Medicine. Department of Gastroenterology. Laboratory of Hepatology and Gastroenterology. São Paulo, SP, Brazil / Albert Einstein Israeli Hospital. Department of Clinical Pathology. São Paulo, SP, BrazilButantan Institute. Viral Immunology Laboratory. Butantã, São Paulo, SP, BrazilSão Paulo State University. Institute of Bioscience, Language & Literature and Exact Science. Department of Biology. São Paulo, SP, BrasilThe quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN therapy, the standard treatment for infection. In this study we analyzed the quasispecies composition of NS5A protein in patients infected with HCV genotype 3a, before IFN therapy.engBioMed CentralHepatite C CrônicaGenótipoDoenças viraisRNA ViralVariação genéticaHepacivirusHumanosHepatitis C ChronicGenotypeAntiviral AgentsRNA ViralGenetic VariationHepacivirusHumansHepatite C CrônicaGenótipoDoenças viraisRNA ViralVariação genéticaHepacivirusHumanosGenetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19308/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBittar C Genetic diversity....pdfBittar C Genetic diversity....pdfapplication/pdf981189https://www.arca.fiocruz.br/bitstream/icict/19308/2/Bittar%20C%20Genetic%20diversity....pdf6096057d15d5a1147f1b96ded30d1ec8MD52TEXTBittar C Genetic diversity....pdf.txtBittar C Genetic diversity....pdf.txtExtracted texttext/plain39665https://www.arca.fiocruz.br/bitstream/icict/19308/3/Bittar%20C%20Genetic%20diversity....pdf.txt1c99a37dddca1d78fa55158218f6b044MD53icict/193082023-03-15 14:34:04.948oai:www.arca.fiocruz.br:icict/19308Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| title |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| spellingShingle |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response Bittar, Cíntia Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos Hepatitis C Chronic Genotype Antiviral Agents RNA Viral Genetic Variation Hepacivirus Humans Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos |
| title_short |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| title_full |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| title_fullStr |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| title_full_unstemmed |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| title_sort |
Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response |
| author |
Bittar, Cíntia |
| author_facet |
Bittar, Cíntia Jardim, Ana Carolina Gomes Yamasaki, Lilian Hiromi Tomonari Yamasaki Queiróz, Artur Trancoso Lopo de Carareto, Claudia Maria Aparecida Pinho, João Renato Rebello Mello, Isabel Maria Vicente Guedes de Carvalho Rahal, Paula |
| author_role |
author |
| author2 |
Jardim, Ana Carolina Gomes Yamasaki, Lilian Hiromi Tomonari Yamasaki Queiróz, Artur Trancoso Lopo de Carareto, Claudia Maria Aparecida Pinho, João Renato Rebello Mello, Isabel Maria Vicente Guedes de Carvalho Rahal, Paula |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bittar, Cíntia Jardim, Ana Carolina Gomes Yamasaki, Lilian Hiromi Tomonari Yamasaki Queiróz, Artur Trancoso Lopo de Carareto, Claudia Maria Aparecida Pinho, João Renato Rebello Mello, Isabel Maria Vicente Guedes de Carvalho Rahal, Paula |
| dc.subject.other.pt_BR.fl_str_mv |
Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos |
| topic |
Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos Hepatitis C Chronic Genotype Antiviral Agents RNA Viral Genetic Variation Hepacivirus Humans Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis C Chronic Genotype Antiviral Agents RNA Viral Genetic Variation Hepacivirus Humans |
| dc.subject.decs.pt_BR.fl_str_mv |
Hepatite C Crônica Genótipo Doenças virais RNA Viral Variação genética Hepacivirus Humanos |
| description |
Artur Trancoso Lopo de Queiroz “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
| dc.date.accessioned.fl_str_mv |
2017-06-06T12:26:18Z |
| dc.date.available.fl_str_mv |
2017-06-06T12:26:18Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BITTAR, C. et al. Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response. BMC Infectious Diseases, v. 10, p. 36, 2010 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19308 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1471-2334 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1471-2334-10-36 |
| identifier_str_mv |
BITTAR, C. et al. Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response. BMC Infectious Diseases, v. 10, p. 36, 2010 1471-2334 10.1186/1471-2334-10-36 |
| url |
https://www.arca.fiocruz.br/handle/icict/19308 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/19308/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/19308/2/Bittar%20C%20Genetic%20diversity....pdf https://www.arca.fiocruz.br/bitstream/icict/19308/3/Bittar%20C%20Genetic%20diversity....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 6096057d15d5a1147f1b96ded30d1ec8 1c99a37dddca1d78fa55158218f6b044 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009295045820416 |