Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.

Detalhes bibliográficos
Autor(a) principal: Zarife, Maria Alice Sant’Anna
Data de Publicação: 2009
Outros Autores: Reis, Eliana Almeida Gomes, Carmo, Theomira Mauadie de Azevedo, Lopes, Gisele Barreto, Brandão, Emilia Carolina Malafaia, Silva, Helder Reis, Santana, Nelma Pereira de, Martins Filho, Olindo Assis, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7516
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, Brasil
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spelling Zarife, Maria Alice Sant’AnnaReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoLopes, Gisele BarretoBrandão, Emilia Carolina MalafaiaSilva, Helder ReisSantana, Nelma Pereira deMartins Filho, Olindo AssisReis, Mitermayer Galvão dos2014-04-14T16:52:19Z2014-04-14T16:52:19Z2009ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009.1096-9071https://www.arca.fiocruz.br/handle/icict/751610.1002/jmv.21340engWiley Periodicals, Inc.Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilA detailed phenotypic analysis of major and minor circulating lymphocyte subsets is described in potential blood donors with markers of hepatitis C virus (HCV), including non-viremic and viremic groups. Although there were no changes in the hematological profile of either group, increased the levels of pre-NK cells (CD3-CD16+CD56-) and a lower frequency of mature NK cells (CD3-CD16+CD56+) characterized innate immunity in the non-viremic group. Both non-viremic and viremic groups displayed significantly increased levels of CD56(Bright) NK cells. Furthermore, this subset was significantly elevated in the viremic subgroup with a low viral load. In addition, an increase in the NKT2 subset was observed only in this subgroup. An enhanced frequency of activated CD4+ T-cells (CD4+HLA-DR+) was a characteristic feature of the non-viremic group, whereas elevated CD19+ B-cells and CD19+CD86+ cell populations were the major phenotypic features of the viremic group, particularly in individuals with a low viral load. Although CD4+CD25High T-cells were significantly elevated in both the viremic and non-viremic groups, it was particularly evident in the viremic low viral load subgroup. A parallel increase in CD4+CD25High T-cells, pre-NK, and activated CD4+ T-cells was observed in the non-viremic group, whereas a parallel increase in CD4+CD25High T-cells and CD19+ B-cells was characteristic of the low viral load subgroup. These findings suggest that CD56Bright NK cells, together with pre-NK cells and activated CD4+ T-cells in combination with CD4+CD25High T-cells, might play an important role in controlling viremia. Elevated CD56(Bright) NK cells, B-cell responses and a T-regulated immunological profile appeared to be associated with a low viral loadHCVBlood donorsNK and NKT cells;Activated T and B cellsCD4+CD25HighAntígenos CD/análiseLinfócitos B/imunologiaDoadores de SangueLinfócitos T CD4-Positivos/imunologiaHepatite C Crônica/imunologiaCélulas Matadoras Naturais/imunologiaSubpopulações de Linfócitos/imunologiaAdultoFemininoHepacivirus/isolamento & purificaçãoHumanosCélulas Matadoras Naturais/químicaMasculinoMeia-IdadeCarga ViralViremia/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALZarife MAS Increased....pdfZarife MAS Increased....pdfapplication/pdf434694https://www.arca.fiocruz.br/bitstream/icict/7516/1/Zarife%20MAS%20Increased....pdf47608a1ca1841dd804fa0f2615e664c7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7516/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTZarife MAS Increased....pdf.txtZarife MAS Increased....pdf.txtExtracted texttext/plain44812https://www.arca.fiocruz.br/bitstream/icict/7516/5/Zarife%20MAS%20Increased....pdf.txt59e5c17c6a2af971b72b5a4d813160caMD55THUMBNAILZarife MAS Increased....pdf.jpgZarife MAS Increased....pdf.jpgGenerated Thumbnailimage/jpeg2380https://www.arca.fiocruz.br/bitstream/icict/7516/4/Zarife%20MAS%20Increased....pdf.jpg61ec9dc8bc1e718bce41f47bbd98a83dMD54icict/75162023-03-15 14:33:17.735oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
title Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
spellingShingle Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
Zarife, Maria Alice Sant’Anna
HCV
Blood donors
NK and NKT cells;
Activated T and B cells
CD4+CD25High
Antígenos CD/análise
Linfócitos B/imunologia
Doadores de Sangue
Linfócitos T CD4-Positivos/imunologia
Hepatite C Crônica/imunologia
Células Matadoras Naturais/imunologia
Subpopulações de Linfócitos/imunologia
Adulto
Feminino
Hepacivirus/isolamento & purificação
Humanos
Células Matadoras Naturais/química
Masculino
Meia-Idade
Carga Viral
Viremia/imunologia
title_short Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
title_full Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
title_fullStr Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
title_full_unstemmed Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
title_sort Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
author Zarife, Maria Alice Sant’Anna
author_facet Zarife, Maria Alice Sant’Anna
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Brandão, Emilia Carolina Malafaia
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
author_role author
author2 Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Brandão, Emilia Carolina Malafaia
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zarife, Maria Alice Sant’Anna
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Brandão, Emilia Carolina Malafaia
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
dc.subject.en.pt_BR.fl_str_mv HCV
Blood donors
NK and NKT cells;
Activated T and B cells
CD4+CD25High
topic HCV
Blood donors
NK and NKT cells;
Activated T and B cells
CD4+CD25High
Antígenos CD/análise
Linfócitos B/imunologia
Doadores de Sangue
Linfócitos T CD4-Positivos/imunologia
Hepatite C Crônica/imunologia
Células Matadoras Naturais/imunologia
Subpopulações de Linfócitos/imunologia
Adulto
Feminino
Hepacivirus/isolamento & purificação
Humanos
Células Matadoras Naturais/química
Masculino
Meia-Idade
Carga Viral
Viremia/imunologia
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD/análise
Linfócitos B/imunologia
Doadores de Sangue
Linfócitos T CD4-Positivos/imunologia
Hepatite C Crônica/imunologia
Células Matadoras Naturais/imunologia
Subpopulações de Linfócitos/imunologia
Adulto
Feminino
Hepacivirus/isolamento & purificação
Humanos
Células Matadoras Naturais/química
Masculino
Meia-Idade
Carga Viral
Viremia/imunologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-04-14T16:52:19Z
dc.date.available.fl_str_mv 2014-04-14T16:52:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7516
dc.identifier.issn.none.fl_str_mv 1096-9071
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.21340
identifier_str_mv ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009.
1096-9071
10.1002/jmv.21340
url https://www.arca.fiocruz.br/handle/icict/7516
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Periodicals, Inc.
publisher.none.fl_str_mv Wiley Periodicals, Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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