Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7516 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, Brasil |
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Zarife, Maria Alice Sant’AnnaReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoLopes, Gisele BarretoBrandão, Emilia Carolina MalafaiaSilva, Helder ReisSantana, Nelma Pereira deMartins Filho, Olindo AssisReis, Mitermayer Galvão dos2014-04-14T16:52:19Z2014-04-14T16:52:19Z2009ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009.1096-9071https://www.arca.fiocruz.br/handle/icict/751610.1002/jmv.21340engWiley Periodicals, Inc.Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilA detailed phenotypic analysis of major and minor circulating lymphocyte subsets is described in potential blood donors with markers of hepatitis C virus (HCV), including non-viremic and viremic groups. Although there were no changes in the hematological profile of either group, increased the levels of pre-NK cells (CD3-CD16+CD56-) and a lower frequency of mature NK cells (CD3-CD16+CD56+) characterized innate immunity in the non-viremic group. Both non-viremic and viremic groups displayed significantly increased levels of CD56(Bright) NK cells. Furthermore, this subset was significantly elevated in the viremic subgroup with a low viral load. In addition, an increase in the NKT2 subset was observed only in this subgroup. An enhanced frequency of activated CD4+ T-cells (CD4+HLA-DR+) was a characteristic feature of the non-viremic group, whereas elevated CD19+ B-cells and CD19+CD86+ cell populations were the major phenotypic features of the viremic group, particularly in individuals with a low viral load. Although CD4+CD25High T-cells were significantly elevated in both the viremic and non-viremic groups, it was particularly evident in the viremic low viral load subgroup. A parallel increase in CD4+CD25High T-cells, pre-NK, and activated CD4+ T-cells was observed in the non-viremic group, whereas a parallel increase in CD4+CD25High T-cells and CD19+ B-cells was characteristic of the low viral load subgroup. These findings suggest that CD56Bright NK cells, together with pre-NK cells and activated CD4+ T-cells in combination with CD4+CD25High T-cells, might play an important role in controlling viremia. Elevated CD56(Bright) NK cells, B-cell responses and a T-regulated immunological profile appeared to be associated with a low viral loadHCVBlood donorsNK and NKT cells;Activated T and B cellsCD4+CD25HighAntígenos CD/análiseLinfócitos B/imunologiaDoadores de SangueLinfócitos T CD4-Positivos/imunologiaHepatite C Crônica/imunologiaCélulas Matadoras Naturais/imunologiaSubpopulações de Linfócitos/imunologiaAdultoFemininoHepacivirus/isolamento & purificaçãoHumanosCélulas Matadoras Naturais/químicaMasculinoMeia-IdadeCarga ViralViremia/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALZarife MAS Increased....pdfZarife MAS Increased....pdfapplication/pdf434694https://www.arca.fiocruz.br/bitstream/icict/7516/1/Zarife%20MAS%20Increased....pdf47608a1ca1841dd804fa0f2615e664c7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7516/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTZarife MAS Increased....pdf.txtZarife MAS Increased....pdf.txtExtracted texttext/plain44812https://www.arca.fiocruz.br/bitstream/icict/7516/5/Zarife%20MAS%20Increased....pdf.txt59e5c17c6a2af971b72b5a4d813160caMD55THUMBNAILZarife MAS Increased....pdf.jpgZarife MAS Increased....pdf.jpgGenerated Thumbnailimage/jpeg2380https://www.arca.fiocruz.br/bitstream/icict/7516/4/Zarife%20MAS%20Increased....pdf.jpg61ec9dc8bc1e718bce41f47bbd98a83dMD54icict/75162023-03-15 14:33:17.735oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
title |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
spellingShingle |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Zarife, Maria Alice Sant’Anna HCV Blood donors NK and NKT cells; Activated T and B cells CD4+CD25High Antígenos CD/análise Linfócitos B/imunologia Doadores de Sangue Linfócitos T CD4-Positivos/imunologia Hepatite C Crônica/imunologia Células Matadoras Naturais/imunologia Subpopulações de Linfócitos/imunologia Adulto Feminino Hepacivirus/isolamento & purificação Humanos Células Matadoras Naturais/química Masculino Meia-Idade Carga Viral Viremia/imunologia |
title_short |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
title_full |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
title_fullStr |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
title_full_unstemmed |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
title_sort |
Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. |
author |
Zarife, Maria Alice Sant’Anna |
author_facet |
Zarife, Maria Alice Sant’Anna Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Lopes, Gisele Barreto Brandão, Emilia Carolina Malafaia Silva, Helder Reis Santana, Nelma Pereira de Martins Filho, Olindo Assis Reis, Mitermayer Galvão dos |
author_role |
author |
author2 |
Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Lopes, Gisele Barreto Brandão, Emilia Carolina Malafaia Silva, Helder Reis Santana, Nelma Pereira de Martins Filho, Olindo Assis Reis, Mitermayer Galvão dos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zarife, Maria Alice Sant’Anna Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Lopes, Gisele Barreto Brandão, Emilia Carolina Malafaia Silva, Helder Reis Santana, Nelma Pereira de Martins Filho, Olindo Assis Reis, Mitermayer Galvão dos |
dc.subject.en.pt_BR.fl_str_mv |
HCV Blood donors NK and NKT cells; Activated T and B cells CD4+CD25High |
topic |
HCV Blood donors NK and NKT cells; Activated T and B cells CD4+CD25High Antígenos CD/análise Linfócitos B/imunologia Doadores de Sangue Linfócitos T CD4-Positivos/imunologia Hepatite C Crônica/imunologia Células Matadoras Naturais/imunologia Subpopulações de Linfócitos/imunologia Adulto Feminino Hepacivirus/isolamento & purificação Humanos Células Matadoras Naturais/química Masculino Meia-Idade Carga Viral Viremia/imunologia |
dc.subject.decs.pt_BR.fl_str_mv |
Antígenos CD/análise Linfócitos B/imunologia Doadores de Sangue Linfócitos T CD4-Positivos/imunologia Hepatite C Crônica/imunologia Células Matadoras Naturais/imunologia Subpopulações de Linfócitos/imunologia Adulto Feminino Hepacivirus/isolamento & purificação Humanos Células Matadoras Naturais/química Masculino Meia-Idade Carga Viral Viremia/imunologia |
description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, Brasil |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2014-04-14T16:52:19Z |
dc.date.available.fl_str_mv |
2014-04-14T16:52:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7516 |
dc.identifier.issn.none.fl_str_mv |
1096-9071 |
dc.identifier.doi.none.fl_str_mv |
10.1002/jmv.21340 |
identifier_str_mv |
ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009. 1096-9071 10.1002/jmv.21340 |
url |
https://www.arca.fiocruz.br/handle/icict/7516 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Wiley Periodicals, Inc. |
publisher.none.fl_str_mv |
Wiley Periodicals, Inc. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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