Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Barbara Castro Pimentel
Data de Publicação: 2015
Outros Autores: Ricci, Natasha Delaqua, Assis, Natan Raimundo Gonçalves de, Morais, Suellen Batistoni de, Fonseca, Cristina Toscano, Oliveira, Sergio Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12591
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil
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spelling Figueiredo, Barbara Castro PimentelRicci, Natasha DelaquaAssis, Natan Raimundo Gonçalves deMorais, Suellen Batistoni deFonseca, Cristina ToscanoOliveira, Sergio Costa2016-01-22T13:14:43Z2016-01-22T13:14:43Z2015FIGUEIREDO, Barbara Castro Pimentel et al. Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development. Front Immunol., vol. 6, art.22, 2015.1664-3224https://www.arca.fiocruz.br/handle/icict/1259110.3389/fimmu.2015.00022engFrontiers Research FoundationKicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrasilSchistosomiasis is a debilitating disease that represents a major health problem in at least 74 tropical and subtropical countries. Current disease control strategies consist mainly of chemotherapy, which cannot prevent recurrent re-infection of people living in endemic area. In the last decades, many researchers made a remarkable effort in the search for an effective vaccine to provide long-term protection. Parasitic platyhelminthes of Schistosoma genus, which cause the disease, live in the blood vessels of definitive hosts where they are bathed in host blood for many years. Among the most promising molecules as vaccine candidates are the proteins present in the host–parasite interface, so numerous tegument antigens have been assessed and the achieved protection never got even close to 100%. Besides the tegument, the digestive tract is the other major site of host–parasite interface. Since parasites feed on blood, they need to swallow a considerable amount of blood for nutrient acquisition. Host blood ingested by schistosomes passes through the esophagus and reaches the gut where many peptidases catalyze the proteolysis of blood cells. Recent studies show the emergence of antigens related to the parasite blood feeding, such as esophageal gland proteins, proteases, and other proteins related to nutrient uptake. Herein, we review what is known about Schistosoma mansoni digestive tract proteins, emphasizing the ones described as potential vaccine candidates.Schistosoma mansonivaccinedigestive tractesophageal glandgastrodermisproteasesesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12591/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKicking in the Guts.pdfKicking in the Guts.pdfapplication/pdf4932855https://www.arca.fiocruz.br/bitstream/icict/12591/2/Kicking%20in%20the%20Guts.pdf23aa7a48b40c9a3b2118d9b92f6f39d7MD52TEXTKicking in the Guts.pdf.txtKicking in the Guts.pdf.txtExtracted texttext/plain262https://www.arca.fiocruz.br/bitstream/icict/12591/3/Kicking%20in%20the%20Guts.pdf.txt5fa29cdddc6dbd7d221d858603f354ecMD53icict/125912019-06-19 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dc.title.pt_BR.fl_str_mv Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
title Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
spellingShingle Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
Figueiredo, Barbara Castro Pimentel
Schistosoma mansoni
vaccine
digestive tract
esophageal gland
gastrodermis
proteaseses
title_short Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
title_full Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
title_fullStr Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
title_full_unstemmed Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
title_sort Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development
author Figueiredo, Barbara Castro Pimentel
author_facet Figueiredo, Barbara Castro Pimentel
Ricci, Natasha Delaqua
Assis, Natan Raimundo Gonçalves de
Morais, Suellen Batistoni de
Fonseca, Cristina Toscano
Oliveira, Sergio Costa
author_role author
author2 Ricci, Natasha Delaqua
Assis, Natan Raimundo Gonçalves de
Morais, Suellen Batistoni de
Fonseca, Cristina Toscano
Oliveira, Sergio Costa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Barbara Castro Pimentel
Ricci, Natasha Delaqua
Assis, Natan Raimundo Gonçalves de
Morais, Suellen Batistoni de
Fonseca, Cristina Toscano
Oliveira, Sergio Costa
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
vaccine
digestive tract
esophageal gland
gastrodermis
proteaseses
topic Schistosoma mansoni
vaccine
digestive tract
esophageal gland
gastrodermis
proteaseses
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunologia de Doenças Infecciosas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-01-22T13:14:43Z
dc.date.available.fl_str_mv 2016-01-22T13:14:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIGUEIREDO, Barbara Castro Pimentel et al. Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development. Front Immunol., vol. 6, art.22, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12591
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2015.00022
identifier_str_mv FIGUEIREDO, Barbara Castro Pimentel et al. Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development. Front Immunol., vol. 6, art.22, 2015.
1664-3224
10.3389/fimmu.2015.00022
url https://www.arca.fiocruz.br/handle/icict/12591
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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