Major randomized clinical studies of alopecia treatment with platelet-rich plasma: a systematic review

• Autor(a) principal: Neiva, Eneidia Batista
• Data de Publicação: 2022
• Outros Autores: Moura, Malú Inês Perez, Murad, Ana Cristyna Saad, Ferrari, Rafaella Scalabrini, Daher, Isabelle Dalloul, Liedtke, Fernanda Soubhia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: MedNEXT Journal of Medical and Health Sciences
• Texto Completo: https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/224
• topic: Alopecia; Platelet-rich plasma; Hair follicle; Aesthetic; Randomized Clinical Studies

Introduction: Alopecia for men and women represents a significant problem worldwide, with around 600,000 hair restoration surgical procedures performed worldwide each year. Thus, the use of platelet-rich plasma (PRP) in regenerative medicine has been investigated for the treatment of alopecia. Objective: We performed a concise systematic review of the main clinical findings of the use of platelet-rich plasma for the treatment of alopecia. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from August to September 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. Scientific articles from the last 5 years were selected. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: PRP was effective in increasing the proliferative activity of hair follicle cells and in increasing capillary density. In androgenetic alopecia, the addition of PRP with microneedling increased effectiveness and shortened the time required for optimal results, as did the combined use of PRP and minoxidil. Conclusion: According to the results of the main randomized controlled trials, platelet-rich plasma showed efficacy in increasing the proliferative activity of hair follicle cells and increasing capillary density.