Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018 |
Resumo: | A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA. |
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Memórias do Instituto Oswaldo Cruz |
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Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein SynthesisPlasmodium falciparumprotein synthesiscell free translationantimalarial drugsA cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.Instituto Oswaldo Cruz, Ministério da Saúde2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018Memórias do Instituto Oswaldo Cruz v.97 n.3 2002reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762002000300018info:eu-repo/semantics/openAccessFerreras,AnaTriana,LediaSánchez,ErlindaHerrera,Floreng2020-04-25T17:48:46Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:11:03.042Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
title |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
spellingShingle |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis Ferreras,Ana Plasmodium falciparum protein synthesis cell free translation antimalarial drugs |
title_short |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
title_full |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
title_fullStr |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
title_full_unstemmed |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
title_sort |
Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis |
author |
Ferreras,Ana |
author_facet |
Ferreras,Ana Triana,Ledia Sánchez,Erlinda Herrera,Flor |
author_role |
author |
author2 |
Triana,Ledia Sánchez,Erlinda Herrera,Flor |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ferreras,Ana Triana,Ledia Sánchez,Erlinda Herrera,Flor |
dc.subject.por.fl_str_mv |
Plasmodium falciparum protein synthesis cell free translation antimalarial drugs |
topic |
Plasmodium falciparum protein synthesis cell free translation antimalarial drugs |
dc.description.none.fl_txt_mv |
A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA. |
description |
A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000300018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762002000300018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.97 n.3 2002 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937685250179072 |