Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice

Detalhes bibliográficos
Autor(a) principal: Tendler,Miriam
Data de Publicação: 1992
Outros Autores: Pinto,Roberto Magalhães, Lima,Antonio de Oliveira, Savino,Wilson, Katz,Naftale
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000500053
Resumo: Previous work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.
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spelling Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred micevaccinationSchistosoma mansonimurine modelantigensPrevious work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000500053Memórias do Instituto Oswaldo Cruz v.87 suppl.1 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000500053info:eu-repo/semantics/openAccessTendler,MiriamPinto,Roberto MagalhãesLima,Antonio de OliveiraSavino,WilsonKatz,Naftaleeng2020-04-25T17:46:56Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:04:59.157Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
spellingShingle Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
Tendler,Miriam
vaccination
Schistosoma mansoni
murine model
antigens
title_short Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_full Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_fullStr Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_full_unstemmed Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_sort Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
author Tendler,Miriam
author_facet Tendler,Miriam
Pinto,Roberto Magalhães
Lima,Antonio de Oliveira
Savino,Wilson
Katz,Naftale
author_role author
author2 Pinto,Roberto Magalhães
Lima,Antonio de Oliveira
Savino,Wilson
Katz,Naftale
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tendler,Miriam
Pinto,Roberto Magalhães
Lima,Antonio de Oliveira
Savino,Wilson
Katz,Naftale
dc.subject.por.fl_str_mv vaccination
Schistosoma mansoni
murine model
antigens
topic vaccination
Schistosoma mansoni
murine model
antigens
dc.description.none.fl_txt_mv Previous work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.
description Previous work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.
publishDate 1992
dc.date.none.fl_str_mv 1992-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000500053
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000500053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000500053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 suppl.1 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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