Comparison of observation periods in mouse inoculation test for the isolation of rabies virus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Vigilância Sanitária em Debate |
Texto Completo: | https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/223 |
Resumo: | Mouse inoculation test (MIT) is routinely used in rabies diagnosis to attest the direct fluorescent antibody test (DFA), however there is no agreement on the minimum observation period. The aim of this study was to evaluate MIT with confirmation by DFA, comparing the diagnostic performance between seven and 21 days held in suckling and weaned mice. For this, 2,953 samples received for rabies diagnosis in the period of 2005- 2011 by Secretaria Municipal de Saúde da Prefeitura da Cidade do Rio de Janeiro were analyzed. Statistical analysis showed high diagnostic sensitivity (97.43%; 95.45%; 100%), and excellent agreement (99.76%; 99.29%; 98.71%) when comparing the results obtained in DFA with the results obtained from suckling mice observed along seven and 21 days and weaned mice respectively. These results infer that MIT performed in seven days using suckling mice enables early diagnosis of rabies, which can anticipate the decisions of health services involved with human prophylactic treatment services, as well as the epidemiological monitoring of rabies. |
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Comparison of observation periods in mouse inoculation test for the isolation of rabies virusComparação de períodos de observação no teste de inoculação em camundongos para o isolamento do vírus da raivaRabiesLaboratory DiagnosisVirus IsolationMouse Inoculation TestPublic HealthRaivaDiagnóstico LaboratorialIsolamento ViralInoculação em CamundongosSaúde PúblicaMouse inoculation test (MIT) is routinely used in rabies diagnosis to attest the direct fluorescent antibody test (DFA), however there is no agreement on the minimum observation period. The aim of this study was to evaluate MIT with confirmation by DFA, comparing the diagnostic performance between seven and 21 days held in suckling and weaned mice. For this, 2,953 samples received for rabies diagnosis in the period of 2005- 2011 by Secretaria Municipal de Saúde da Prefeitura da Cidade do Rio de Janeiro were analyzed. Statistical analysis showed high diagnostic sensitivity (97.43%; 95.45%; 100%), and excellent agreement (99.76%; 99.29%; 98.71%) when comparing the results obtained in DFA with the results obtained from suckling mice observed along seven and 21 days and weaned mice respectively. These results infer that MIT performed in seven days using suckling mice enables early diagnosis of rabies, which can anticipate the decisions of health services involved with human prophylactic treatment services, as well as the epidemiological monitoring of rabies.O teste de inoculação intracerebral em camundongos (IC) é rotineiramente utilizado no diagnóstico da raiva para ratificar o teste de imunofluorescência direta (IFD); no entanto não existe concordância sobre o tempo mínimo de observação dos animais. O objetivo do presente estudo foi avaliar a IC com confirmação por IFD, comparando o desempenho do diagnóstico em sete dias com aquele realizado em 21 dias de observação em camundongos lactentes e desmamados. Foram utilizadas 2.953 amostras de animais suspeitos, recebidas para diagnóstico de raiva no período de 2005 a 2011 na Secretaria Municipal de Saúde da Prefeitura da Cidade do Rio de Janeiro. A análise estatística demonstrou elevada sensibilidade do diagnóstico (97,43%; 95,45%; 100%) e excelente concordância (99,76%; 99,29%; 98,71%) ao comparar os resultados na IFD com os obtidos em camundongos lactentes observados por sete e 21 dias e desmamados, respectivamente. Estes resultados inferem que a IC realizada em sete dias em camundongos lactentes possibilita a precocidade do diagnóstico de raiva, o que pode antecipar a tomada de decisões dos serviços de saúde envolvidos com o tratamento profilático antirrábico humano, bem como as ações dos serviços de vigilância epidemiológica da doença.Instituto Nacional de Controle de Qualidade em Saúde2015-08-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed article""Artículo revisado por pares""Artigo avaliado pelos pares"application/pdfhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/22310.3395/2317-269x.00223Health Surveillance under Debate: Society, Science & Technology ; Vol. 3 No. 3 (2015): August; 47-55Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 3 Núm. 3 (2015): Agosto; 47-55Vigil Sanit Debate, Rio de Janeiro; v. 3 n. 3 (2015): Agosto; 47-552317-269Xreponame:Vigilância Sanitária em Debateinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/223/191Copyright (c) 2015 Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debatehttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessde Morais, Ana Carolina NunesCabral, Claudius CoutoDias, Alba Valéria de Almeida BarcelosAraújo, Marcela GarciaMattos, Gláucio Luís MataMoreira, Wildeberg Cál2023-06-27T15:00:17Zoai:ojs.visaemdebate.incqs.fiocruz.br:article/223Revistahttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebatePUBhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/oaiincqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br2317-269X2317-269Xopendoar:2023-06-27T15:00:17Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus Comparação de períodos de observação no teste de inoculação em camundongos para o isolamento do vírus da raiva |
title |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
spellingShingle |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus de Morais, Ana Carolina Nunes Rabies Laboratory Diagnosis Virus Isolation Mouse Inoculation Test Public Health Raiva Diagnóstico Laboratorial Isolamento Viral Inoculação em Camundongos Saúde Pública |
title_short |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
title_full |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
title_fullStr |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
title_full_unstemmed |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
title_sort |
Comparison of observation periods in mouse inoculation test for the isolation of rabies virus |
author |
de Morais, Ana Carolina Nunes |
author_facet |
de Morais, Ana Carolina Nunes Cabral, Claudius Couto Dias, Alba Valéria de Almeida Barcelos Araújo, Marcela Garcia Mattos, Gláucio Luís Mata Moreira, Wildeberg Cál |
author_role |
author |
author2 |
Cabral, Claudius Couto Dias, Alba Valéria de Almeida Barcelos Araújo, Marcela Garcia Mattos, Gláucio Luís Mata Moreira, Wildeberg Cál |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
de Morais, Ana Carolina Nunes Cabral, Claudius Couto Dias, Alba Valéria de Almeida Barcelos Araújo, Marcela Garcia Mattos, Gláucio Luís Mata Moreira, Wildeberg Cál |
dc.subject.por.fl_str_mv |
Rabies Laboratory Diagnosis Virus Isolation Mouse Inoculation Test Public Health Raiva Diagnóstico Laboratorial Isolamento Viral Inoculação em Camundongos Saúde Pública |
topic |
Rabies Laboratory Diagnosis Virus Isolation Mouse Inoculation Test Public Health Raiva Diagnóstico Laboratorial Isolamento Viral Inoculação em Camundongos Saúde Pública |
description |
Mouse inoculation test (MIT) is routinely used in rabies diagnosis to attest the direct fluorescent antibody test (DFA), however there is no agreement on the minimum observation period. The aim of this study was to evaluate MIT with confirmation by DFA, comparing the diagnostic performance between seven and 21 days held in suckling and weaned mice. For this, 2,953 samples received for rabies diagnosis in the period of 2005- 2011 by Secretaria Municipal de Saúde da Prefeitura da Cidade do Rio de Janeiro were analyzed. Statistical analysis showed high diagnostic sensitivity (97.43%; 95.45%; 100%), and excellent agreement (99.76%; 99.29%; 98.71%) when comparing the results obtained in DFA with the results obtained from suckling mice observed along seven and 21 days and weaned mice respectively. These results infer that MIT performed in seven days using suckling mice enables early diagnosis of rabies, which can anticipate the decisions of health services involved with human prophylactic treatment services, as well as the epidemiological monitoring of rabies. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion "Peer-reviewed article" "Artículo revisado por pares" "Artigo avaliado pelos pares" |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/223 10.3395/2317-269x.00223 |
url |
https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/223 |
identifier_str_mv |
10.3395/2317-269x.00223 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/223/191 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Nacional de Controle de Qualidade em Saúde |
publisher.none.fl_str_mv |
Instituto Nacional de Controle de Qualidade em Saúde |
dc.source.none.fl_str_mv |
Health Surveillance under Debate: Society, Science & Technology ; Vol. 3 No. 3 (2015): August; 47-55 Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 3 Núm. 3 (2015): Agosto; 47-55 Vigil Sanit Debate, Rio de Janeiro; v. 3 n. 3 (2015): Agosto; 47-55 2317-269X reponame:Vigilância Sanitária em Debate instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Vigilância Sanitária em Debate |
collection |
Vigilância Sanitária em Debate |
repository.name.fl_str_mv |
Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
incqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br |
_version_ |
1797042043483062272 |