Toxicological screening of extracts from Pimenta pseudocaryophyllum (Gomes) L.R. Landrum on Artemia salina Leach

• Autor(a) principal: Menezes, Daniela de Alencar
• Data de Publicação: 2019
• Outros Autores: Novaes da Silva, Artur Danilo, Dantas, Gabriela Saraiva, Souza Lima Silva, Helder Carvalho, Lyra, Ricardo Prado, Lucêna de Lima, Bruno, Silva, Fabiana Lima, Hrihorowitsch Moreno, Paulo Roberto, Beserra de Oliveira, Thárcia Kiara, Veiga da Silva, Joelmir Lucena
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Anais da Faculdade de Medicina de Olinda (Online)
• Texto Completo: https://afmo.emnuvens.com.br/afmo/article/view/55
• topic: Planta medicinal. Extrato vegetal. Toxicidade.; Medicinal plant. Vegetal extract. Toxicity.

Objective: to verify and to compare the acute toxicity of the leaves (Ppf) and stalk (PPc) extracts from Pimenta pseudocaryophyllum on brine shrimp Artemia salina. Methods: Ppf and Ppc extracts (1, 10, 100 nd 1000 μg/mL) were evaluate the assay acute toxicity on Artemia salina, incubed at 24 and 48 hours, performed at triplicate. The nauplii dead number were determined and LC50 was calculated by non-linear regression. Results: Ppc extract presents toxicity only at 48hs (LC50 = 140.2 ± 76.7 μg/mL), regarded as moderate toxicity. Ppf was toxic both at 24hs (LC50 = 372.0 ± 58.1 μg/mL) and 48hs (LC50 = 0.8 ± 0.1 μg/mL), regarded as moderate and high toxicity, respectivelly. Conclusion: leaf and stalk from P. pseudocaryophyllum presents active metabolites that induced toxicity Artemia salina, probably, are different substances or most concentrated on leaves.