Drug resistance in Helicobacter pylori

Detalhes bibliográficos
Autor(a) principal: Vianna, Júlia Silveira
Data de Publicação: 2016
Outros Autores: Ramis, Ivy Bastos, Soares, Daniela Fernandes Ramos, Groll, Andrea Von, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7103
http://dx.doi.org/10.1590/S0004-28032016000400002
Resumo: Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.
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spelling Drug resistance in Helicobacter pyloriA resistência de helicobacter pylori aos antimicrobianos.Helicobacter pyloriMicrobial drug resistancePoint mutationResistência microbiana a medicamentosMutação pontualBackground Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.Contexto Helicobacter pylori tem uma distribuição a nível mundial, e está associado a patogênese de várias doenças do sistema digestivo. O tratamento para a erradicação deste microrganismo envolve a utilização de uma combinação de agentes antimicrobianos, tais como amoxicilina, metronidazol, claritromicina e levofloxacino, combinados com inibidores da bomba de prótons. Embora a terapia atual seja eficaz, uma elevada taxa de fracasso de tratamento tem sido observada, principalmente devido à aquisição de mutações pontuais, um dos principais mecanismos de resistência desenvolvida por H. pylori, relacionado com o uso frequente e/ou inadequado dos antibióticos. Conclusão Esta revisão abordou uma visão geral da resistência às principais drogas utilizadas no tratamento de H. pylori, confirmando a hipótese de que a resistência bacteriana é um fenômeno altamente local e as características genéticas de uma dada população podem influenciar qual terapia é a mais apropriada.2017-03-14T20:50:19Z2017-03-14T20:50:19Z2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfVIANNA, Júlia Silveira et al. Drug resistance in Helicobacter pylori. Arquivos de Gastroenterologia. vol. 53, n. 4 , p. 215, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215>. Acesso em: 14 mar. 2017.0004-2803http://repositorio.furg.br/handle/1/7103http://dx.doi.org/10.1590/S0004-28032016000400002porVianna, Júlia SilveiraRamis, Ivy BastosSoares, Daniela Fernandes RamosGroll, Andrea VonSilva, Pedro Eduardo Almeida dainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2019-12-03T20:22:41Zoai:repositorio.furg.br:1/7103Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-12-03T20:22:41Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv Drug resistance in Helicobacter pylori
A resistência de helicobacter pylori aos antimicrobianos.
title Drug resistance in Helicobacter pylori
spellingShingle Drug resistance in Helicobacter pylori
Vianna, Júlia Silveira
Helicobacter pylori
Microbial drug resistance
Point mutation
Resistência microbiana a medicamentos
Mutação pontual
title_short Drug resistance in Helicobacter pylori
title_full Drug resistance in Helicobacter pylori
title_fullStr Drug resistance in Helicobacter pylori
title_full_unstemmed Drug resistance in Helicobacter pylori
title_sort Drug resistance in Helicobacter pylori
author Vianna, Júlia Silveira
author_facet Vianna, Júlia Silveira
Ramis, Ivy Bastos
Soares, Daniela Fernandes Ramos
Groll, Andrea Von
Silva, Pedro Eduardo Almeida da
author_role author
author2 Ramis, Ivy Bastos
Soares, Daniela Fernandes Ramos
Groll, Andrea Von
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vianna, Júlia Silveira
Ramis, Ivy Bastos
Soares, Daniela Fernandes Ramos
Groll, Andrea Von
Silva, Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv Helicobacter pylori
Microbial drug resistance
Point mutation
Resistência microbiana a medicamentos
Mutação pontual
topic Helicobacter pylori
Microbial drug resistance
Point mutation
Resistência microbiana a medicamentos
Mutação pontual
description Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017-03-14T20:50:19Z
2017-03-14T20:50:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv VIANNA, Júlia Silveira et al. Drug resistance in Helicobacter pylori. Arquivos de Gastroenterologia. vol. 53, n. 4 , p. 215, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215>. Acesso em: 14 mar. 2017.
0004-2803
http://repositorio.furg.br/handle/1/7103
http://dx.doi.org/10.1590/S0004-28032016000400002
identifier_str_mv VIANNA, Júlia Silveira et al. Drug resistance in Helicobacter pylori. Arquivos de Gastroenterologia. vol. 53, n. 4 , p. 215, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215>. Acesso em: 14 mar. 2017.
0004-2803
url http://repositorio.furg.br/handle/1/7103
http://dx.doi.org/10.1590/S0004-28032016000400002
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da FURG (RI FURG)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
repository.name.fl_str_mv Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv
_version_ 1807384356004560896

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