DRUG RESISTANCE IN HELICOBACTER PYLORI

Detalhes bibliográficos
Autor(a) principal: VIANNA,Júlia Silveira
Data de Publicação: 2016
Outros Autores: RAMIS,Ivy Bastos, RAMOS,Daniela Fernandes, VON GROLL,Andrea, SILVA,Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215
Resumo: ABSTRACT Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.
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spelling DRUG RESISTANCE IN HELICOBACTER PYLORIHelicobacter pyloriMicrobial drug resistancePoint mutationABSTRACT Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215Arquivos de Gastroenterologia v.53 n.4 2016reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/S0004-28032016000400002info:eu-repo/semantics/openAccessVIANNA,Júlia SilveiraRAMIS,Ivy BastosRAMOS,Daniela FernandesVON GROLL,AndreaSILVA,Pedro Eduardo Almeida daeng2016-09-27T00:00:00Zoai:scielo:S0004-28032016000400215Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2016-09-27T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv DRUG RESISTANCE IN HELICOBACTER PYLORI
title DRUG RESISTANCE IN HELICOBACTER PYLORI
spellingShingle DRUG RESISTANCE IN HELICOBACTER PYLORI
VIANNA,Júlia Silveira
Helicobacter pylori
Microbial drug resistance
Point mutation
title_short DRUG RESISTANCE IN HELICOBACTER PYLORI
title_full DRUG RESISTANCE IN HELICOBACTER PYLORI
title_fullStr DRUG RESISTANCE IN HELICOBACTER PYLORI
title_full_unstemmed DRUG RESISTANCE IN HELICOBACTER PYLORI
title_sort DRUG RESISTANCE IN HELICOBACTER PYLORI
author VIANNA,Júlia Silveira
author_facet VIANNA,Júlia Silveira
RAMIS,Ivy Bastos
RAMOS,Daniela Fernandes
VON GROLL,Andrea
SILVA,Pedro Eduardo Almeida da
author_role author
author2 RAMIS,Ivy Bastos
RAMOS,Daniela Fernandes
VON GROLL,Andrea
SILVA,Pedro Eduardo Almeida da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv VIANNA,Júlia Silveira
RAMIS,Ivy Bastos
RAMOS,Daniela Fernandes
VON GROLL,Andrea
SILVA,Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv Helicobacter pylori
Microbial drug resistance
Point mutation
topic Helicobacter pylori
Microbial drug resistance
Point mutation
description ABSTRACT Background Helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. Treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. Although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the major resistance mechanisms developed by H. pylori. This phenomenon is related to frequent and/or inappropriate use of antibiotics. Conclusion This review reported an overview of the resistance to the main drugs used in the treatment of H. pylori, confirming the hypothesis that antibacterial resistance is a highly local phenomenon and genetic characteristics of a given population can influence which therapy is the most appropriate.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032016000400215
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-28032016000400002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.53 n.4 2016
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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