Persea major: Content of Total Phenolic Compounds and Masterful Development of Gel for Application in Endodontics.

• Autor(a) principal: Ferreira , Daiane Finger
• Data de Publicação: 2024
• Outros Autores: Herrerias , Tatiana, Ludwig, Daniel Brustolin, Martins, Marcos Vinicius Soares, Martins, Hilana Rickli Fiuza, Chao, Bárbara Mendes Paz, de Camargo, Luciana Erzinger Alves de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1461
• topic: Compostos fenólicos,; Produto natural; Extração; Atividade antibacteriana; endodontia; Phenolic compounds; Natural producT; Natural product; Extraction; Antibacterial activity; endodontics

Persea major (Pau de Andrade), is a plant native to southern Brazil known for its medicinal properties, focusing on the bark as a raw material. The growing interest in herbal medicine research stands out, moving sustainable resources towards the development of medicines. Persea major has traditionally been used due to its gastroprotective, antibacterial and antiseptic healing properties, although there is a paucity of publications on its use. Phytochemical studies revealed the presence of bioactive compounds, such as benzyl tetrahydroisoquinoline alkaloids, flavonoids and tannins, with pharmacological potential, including cytotoxic action against cancer cells. However, its potential in Endodontics remains little explored. In the present study, phenolic compounds were extracted from three different solvents, water, ethanol:water (70:30 v/v) and ethanol:water:acetic acid (70:25:5) and then the total concentration of phenolics was quantified by Folin-Ciocalteau method. The most significant result of total phenolic compounds was observed in the acidified hydroethanolic extract sample (439.9 ± 1.22mg/mL), followed by the hydroethanolic extract sample (153.2 ± 1.38mg/mL) and the extract sample aqueous (98.8 ± 1.52mg/mL). Subsequently, a pilot formulation of gel containing Persea major was developed for endodontic use, lesions to bacterial elimination in root canals, with emphasis on the eradication of Enterococcus faecalis, a bacterium known for its resistance to conventional treatments.