Evaluation of carcinogenesis in Drosophila melanogaster exposed to ethylenediamino tetraacetic acid (EDTA)

• Autor(a) principal: Côrtes Caixeta, Michelly
• Data de Publicação: 2023
• Outros Autores: Matias, Gabriel Henrique, Bíscaro Pereira, Leonardo, Capelari Orsolin, Priscila, Borges, Daniella Cristina
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/836
• topic: Ácido Etilenodiaminotetracético; Drosophila melanogaster; Odontologia; Edetic Acid; Drosophila melanogaster; Denstistry

The mechanical action of dental instruments on the dentin wall releases dentin shavings and organic residues, which, mixed with chemical substances, form an amorphous substance that tends to impregnate the dentin surface, called smear layer. Ethylenediaminetetraacetic acid (EDTA), in concentrations of 17% and 24%, is a chelating agent, capable of removing the smear layer from the surface of dentin walls, this solution being the most used in the areas of Endodontics and Periodontics. The research aimed to evaluate the carcinogenic potential of ethylenediaminetetraacetic acid (EDTA) at a concentration of 24%, used in periodontal surgical procedures, through the Epithelial Tumor Test (ETT) in Drosophila melanogaster, using doxorubicin as a positive control and reverse osmosis water as a negative control. Drosophila melanogaster were exposed to four different dilutions of 24% EDTA: 1:100, 1:200, 1:400 and 1:800. The results obtained were compared to the values of the control groups. An increase in the frequency of tumors was observed in all dilutions when compared to the negative control group and the EDTA 1:200 and 1:400 groups presented statistics significantly similar to the positive control group. The data obtained demonstrate that there is an increase in tumor frequency in Drosophila melanogaster exposed to EDTA. However, more research is needed to confirm its carcinogenicity.