Thrombophilia and immune-related genetic markers in long COVID

Detalhes bibliográficos
Autor(a) principal: Silva, Rosilene da
Data de Publicação: 2023
Outros Autores: Sarges, Kevin Matheus Lima de, Cantanhede, Marcos Henrique Damasceno, Costa, Flávia Póvoa da, Santos, Erika Ferreira dos, Rodrigues, Fabíola Brasil Barbosa, Viana, Maria de Nazaré do Socorro de Almeida, Leite, Mauro de Meira, Silva, Andréa Luciana Soares da, Brito, Mioni Thieli Magalhães de, Torres, Maria Karoliny da Silva, Queiroz, Maria Alice Freitas, Vallinoto, Izaura Maria Vieira Cayres, Henriques, Daniele Freitas, Santos, Carla Pinheiro dos, Vianna, Giselle Maria Rachid, Quaresma, Juarez Antônio Simões, Falcão, Luiz Fábio Magno, Vallinoto, Antonio Carlos Rosário, Santos, Eduardo José Melo dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6821
Resumo: Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.
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spelling Silva, Rosilene daSarges, Kevin Matheus Lima deCantanhede, Marcos Henrique DamascenoCosta, Flávia Póvoa daSantos, Erika Ferreira dosRodrigues, Fabíola Brasil BarbosaViana, Maria de Nazaré do Socorro de AlmeidaLeite, Mauro de MeiraSilva, Andréa Luciana Soares daBrito, Mioni Thieli Magalhães deTorres, Maria Karoliny da SilvaQueiroz, Maria Alice FreitasVallinoto, Izaura Maria Vieira CayresHenriques, Daniele FreitasSantos, Carla Pinheiro dosVianna, Giselle Maria RachidQuaresma, Juarez Antônio SimõesFalcão, Luiz Fábio MagnoVallinoto, Antonio Carlos RosárioSantos, Eduardo José Melo dos2023-05-15T13:34:03Z2023-05-15T13:34:03Z2023SILVA, Rosilene da et al. Thrombophilia and immune-related genetic markers in long COVID. Viruses, v. 15, n. 4, p. 1-13, 2023. DOI: https://doi.org/10.3390/v15040885. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143911/1999-4915https://patua.iec.gov.br/handle/iec/682110.3390/v15040885Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.Secretary of Science, Technology and Higher, Professional and Technological Education of the State of Pará (SECTET #09/2021), Amazon Foundation for Research Support (FAPESPA)—#006/2020 and #060/2020, The Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPQ)—#401235/2020-3.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Clinical Analysis. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Clinical Analysis. Belém, PA, Brazil.Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Pesquisa Básica da Malária. Ananindeua, PA, Brasil.Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Graduate Program in Clinical Analysis. 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dc.title.pt_BR.fl_str_mv Thrombophilia and immune-related genetic markers in long COVID
title Thrombophilia and immune-related genetic markers in long COVID
spellingShingle Thrombophilia and immune-related genetic markers in long COVID
Silva, Rosilene da
COVID-19 / imunologia
SARS-CoV-2 / imunologia
Síndrome Pós-COVID-19 Aguda
Trombofilia
title_short Thrombophilia and immune-related genetic markers in long COVID
title_full Thrombophilia and immune-related genetic markers in long COVID
title_fullStr Thrombophilia and immune-related genetic markers in long COVID
title_full_unstemmed Thrombophilia and immune-related genetic markers in long COVID
title_sort Thrombophilia and immune-related genetic markers in long COVID
author Silva, Rosilene da
author_facet Silva, Rosilene da
Sarges, Kevin Matheus Lima de
Cantanhede, Marcos Henrique Damasceno
Costa, Flávia Póvoa da
Santos, Erika Ferreira dos
Rodrigues, Fabíola Brasil Barbosa
Viana, Maria de Nazaré do Socorro de Almeida
Leite, Mauro de Meira
Silva, Andréa Luciana Soares da
Brito, Mioni Thieli Magalhães de
Torres, Maria Karoliny da Silva
Queiroz, Maria Alice Freitas
Vallinoto, Izaura Maria Vieira Cayres
Henriques, Daniele Freitas
Santos, Carla Pinheiro dos
Vianna, Giselle Maria Rachid
Quaresma, Juarez Antônio Simões
Falcão, Luiz Fábio Magno
Vallinoto, Antonio Carlos Rosário
Santos, Eduardo José Melo dos
author_role author
author2 Sarges, Kevin Matheus Lima de
Cantanhede, Marcos Henrique Damasceno
Costa, Flávia Póvoa da
Santos, Erika Ferreira dos
Rodrigues, Fabíola Brasil Barbosa
Viana, Maria de Nazaré do Socorro de Almeida
Leite, Mauro de Meira
Silva, Andréa Luciana Soares da
Brito, Mioni Thieli Magalhães de
Torres, Maria Karoliny da Silva
Queiroz, Maria Alice Freitas
Vallinoto, Izaura Maria Vieira Cayres
Henriques, Daniele Freitas
Santos, Carla Pinheiro dos
Vianna, Giselle Maria Rachid
Quaresma, Juarez Antônio Simões
Falcão, Luiz Fábio Magno
Vallinoto, Antonio Carlos Rosário
Santos, Eduardo José Melo dos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Rosilene da
Sarges, Kevin Matheus Lima de
Cantanhede, Marcos Henrique Damasceno
Costa, Flávia Póvoa da
Santos, Erika Ferreira dos
Rodrigues, Fabíola Brasil Barbosa
Viana, Maria de Nazaré do Socorro de Almeida
Leite, Mauro de Meira
Silva, Andréa Luciana Soares da
Brito, Mioni Thieli Magalhães de
Torres, Maria Karoliny da Silva
Queiroz, Maria Alice Freitas
Vallinoto, Izaura Maria Vieira Cayres
Henriques, Daniele Freitas
Santos, Carla Pinheiro dos
Vianna, Giselle Maria Rachid
Quaresma, Juarez Antônio Simões
Falcão, Luiz Fábio Magno
Vallinoto, Antonio Carlos Rosário
Santos, Eduardo José Melo dos
dc.subject.decsPrimary.pt_BR.fl_str_mv COVID-19 / imunologia
SARS-CoV-2 / imunologia
Síndrome Pós-COVID-19 Aguda
Trombofilia
topic COVID-19 / imunologia
SARS-CoV-2 / imunologia
Síndrome Pós-COVID-19 Aguda
Trombofilia
description Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-15T13:34:03Z
dc.date.available.fl_str_mv 2023-05-15T13:34:03Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv SILVA, Rosilene da et al. Thrombophilia and immune-related genetic markers in long COVID. Viruses, v. 15, n. 4, p. 1-13, 2023. DOI: https://doi.org/10.3390/v15040885. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143911/
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6821
dc.identifier.issn.-.fl_str_mv 1999-4915
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/v15040885
identifier_str_mv SILVA, Rosilene da et al. Thrombophilia and immune-related genetic markers in long COVID. Viruses, v. 15, n. 4, p. 1-13, 2023. DOI: https://doi.org/10.3390/v15040885. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143911/
1999-4915
10.3390/v15040885
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