Thrombophilia and immune-related genetic markers in long COVID

• Autor(a) principal: Silva, Rosilene da
• Data de Publicação: 2023
• Outros Autores: Sarges, Kevin Matheus Lima de, Cantanhede, Marcos Henrique Damasceno, Costa, Flávia Póvoa da, Santos, Erika Ferreira dos, Rodrigues, Fabíola Brasil Barbosa, Viana, Maria de Nazaré do Socorro de Almeida, Leite, Mauro de Meira, Silva, Andréa Luciana Soares da, Brito, Mioni Thieli Magalhães de, Torres, Maria Karoliny da Silva, Queiroz, Maria Alice Freitas, Vallinoto, Izaura Maria Vieira Cayres, Henriques, Daniele Freitas, Santos, Carla Pinheiro dos, Vianna, Giselle Maria Rachid, Quaresma, Juarez Antônio Simões, Falcão, Luiz Fábio Magno, Vallinoto, Antonio Carlos Rosário, Santos, Eduardo José Melo dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6821
• topic: COVID-19 / imunologia; SARS-CoV-2 / imunologia; Síndrome Pós-COVID-19 Aguda; Trombofilia

Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.