Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection

Detalhes bibliográficos
Autor(a) principal: Lima, Luciana Vieira do Rêgo
Data de Publicação: 2014
Outros Autores: Ramos, Patrícia Karla Santos, Campos, Marliane Batista, Santos, Thiago Vasconcelos dos, Gomes, Claudia Maria de Castro, Laurenti, Márcia Dalastra, Corbett, Carlos Eduardo Pereira, Silveira, Fernando Tobias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/1067
Resumo: American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection - AI, Sub-clinical Resistant Infection - SRI, and Indeterminate Initial Infection - III), and two symptomatic ones [Symptomatic Infection - SI ( = AVL) and Sub-clinical Oligosymptomatic Infection - SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.
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spelling Lima, Luciana Vieira do RêgoRamos, Patrícia Karla SantosCampos, Marliane BatistaSantos, Thiago Vasconcelos dosGomes, Claudia Maria de CastroLaurenti, Márcia DalastraCorbett, Carlos Eduardo PereiraSilveira, Fernando Tobias2016-01-26T11:43:21Z2016-01-26T11:43:21Z2014LIMA, Luciana Vieira do Rêgo et al. Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection. Pathogens and Global Health, v. 108, n. 8, p. 381-384, Dec. 20142047-7732https://patua.iec.gov.br/handle/iec/106710.1179/2047773214Y.0000000166American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection - AI, Sub-clinical Resistant Infection - SRI, and Indeterminate Initial Infection - III), and two symptomatic ones [Symptomatic Infection - SI ( = AVL) and Sub-clinical Oligosymptomatic Infection - SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.This work was supported by Instituto Evandro Chagas (Secretaria de Vigilância em Saúde, Ministério da Saúde, Brazil); Núcleo de Medicina Tropical (Universidade Federal do Pará´, Brazil); Laboratório de Investigação Médica (LIM)-50 (Hospital de Clínicas (HC)-Faculdade de Medicina (FM)-Universidade de São Paulo (USP), Brazil), and Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP: 06/56319- 1, Brazil)Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.São Paulo University. Medical School. Pathology Department. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Tropical Medicine Nucleus. Belém, PA, Brazil.application/pdfengTaylor & FrancisPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniose / diagnósticoImunoglobulina M / uso diagnósticoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdfPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdfapplication/pdf172304https://patua.iec.gov.br/bitstreams/7132d2dd-04e4-4e9d-b0c8-2c9b669458d1/downloada9e033875f3b09b78b647fc86c5298baMD51TEXTPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdf.txtPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdf.txtExtracted texttext/plain19538https://patua.iec.gov.br/bitstreams/ed8cc15c-abee-40fb-9ada-70404e631135/download3411a4d91f324bbafed42ddb578e1373MD55THUMBNAILPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdf.jpgPreclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection.pdf.jpgGenerated Thumbnailimage/jpeg6213https://patua.iec.gov.br/bitstreams/64b61955-4fb0-44d0-a503-db55601f4583/download3f194c7ad722cf29035efe65cddfbeb3MD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
title Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
spellingShingle Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
Lima, Luciana Vieira do Rêgo
Leishmaniose / diagnóstico
Imunoglobulina M / uso diagnóstico
title_short Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
title_full Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
title_fullStr Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
title_full_unstemmed Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
title_sort Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection
author Lima, Luciana Vieira do Rêgo
author_facet Lima, Luciana Vieira do Rêgo
Ramos, Patrícia Karla Santos
Campos, Marliane Batista
Santos, Thiago Vasconcelos dos
Gomes, Claudia Maria de Castro
Laurenti, Márcia Dalastra
Corbett, Carlos Eduardo Pereira
Silveira, Fernando Tobias
author_role author
author2 Ramos, Patrícia Karla Santos
Campos, Marliane Batista
Santos, Thiago Vasconcelos dos
Gomes, Claudia Maria de Castro
Laurenti, Márcia Dalastra
Corbett, Carlos Eduardo Pereira
Silveira, Fernando Tobias
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Luciana Vieira do Rêgo
Ramos, Patrícia Karla Santos
Campos, Marliane Batista
Santos, Thiago Vasconcelos dos
Gomes, Claudia Maria de Castro
Laurenti, Márcia Dalastra
Corbett, Carlos Eduardo Pereira
Silveira, Fernando Tobias
dc.subject.decsPrimary.pt_BR.fl_str_mv Leishmaniose / diagnóstico
Imunoglobulina M / uso diagnóstico
topic Leishmaniose / diagnóstico
Imunoglobulina M / uso diagnóstico
description American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection - AI, Sub-clinical Resistant Infection - SRI, and Indeterminate Initial Infection - III), and two symptomatic ones [Symptomatic Infection - SI ( = AVL) and Sub-clinical Oligosymptomatic Infection - SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-01-26T11:43:21Z
dc.date.available.fl_str_mv 2016-01-26T11:43:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Luciana Vieira do Rêgo et al. Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection. Pathogens and Global Health, v. 108, n. 8, p. 381-384, Dec. 2014
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/1067
dc.identifier.issn.-.fl_str_mv 2047-7732
dc.identifier.doi.-.fl_str_mv 10.1179/2047773214Y.0000000166
identifier_str_mv LIMA, Luciana Vieira do Rêgo et al. Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L) infantum chagasi-infection. Pathogens and Global Health, v. 108, n. 8, p. 381-384, Dec. 2014
2047-7732
10.1179/2047773214Y.0000000166
url https://patua.iec.gov.br/handle/iec/1067
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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