The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2498 |
Resumo: | Background: The virulence and pathogenicity of different influenza strains are responsible for a more or less severe disease. Recent studies have attempted to understand how host genetic factors may influence the clinical presentation of the disease. In the present study, the His131Arg (rs1801274) polymorphism was investigated in individuals from a Brazilian admixed population with a diagnosis of influenza A(H1N1)pdm09 infection. Methods: In the present study, the influence of the His131Arg (rs1801274) polymorphism, a variant of the FCGR2A gene, was investigated in 436 patients with a diagnosis of influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010. Patients were divided into a group of non-hospitalized patients (n = 192) and a group of hospitalized patients (n = 244; 100 of them died). Results: No significant difference in the allele or genotype frequencies of the rs1801274 polymorphism was observed between groups (p = 0.952 and p = 0.388). Multinomial logistic regression showed no effect of the rs1801274 polymorphism on severity or death of patients from the Brazilian admixed population (p = 0.368 and p = 0.469). Conclusions: The rs1801274 polymorphism is not associated with severe disease in patients infected with influenza A(H1N1)pdm09. |
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Maestri, AlvinoSortica, Vinicius AlbuquerqueFerreira, Deimy LimaFerreira, Jessylene de AlmeidaAmador, Marcos Antônio TrindadeMello, Wyller Alencar deSantos, Sidney Emanuel BatistaSousa, Rita Catarina Medeiros2017-02-09T19:39:09Z2017-02-09T19:39:09Z2016MAESTRI, Alvino et al. The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection. BMC Research Notes, v. 9, p. 296, 2016.https://patua.iec.gov.br/handle/iec/249810.1186/s13104-016-2096-1Background: The virulence and pathogenicity of different influenza strains are responsible for a more or less severe disease. Recent studies have attempted to understand how host genetic factors may influence the clinical presentation of the disease. In the present study, the His131Arg (rs1801274) polymorphism was investigated in individuals from a Brazilian admixed population with a diagnosis of influenza A(H1N1)pdm09 infection. Methods: In the present study, the influence of the His131Arg (rs1801274) polymorphism, a variant of the FCGR2A gene, was investigated in 436 patients with a diagnosis of influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010. Patients were divided into a group of non-hospitalized patients (n = 192) and a group of hospitalized patients (n = 244; 100 of them died). Results: No significant difference in the allele or genotype frequencies of the rs1801274 polymorphism was observed between groups (p = 0.952 and p = 0.388). Multinomial logistic regression showed no effect of the rs1801274 polymorphism on severity or death of patients from the Brazilian admixed population (p = 0.368 and p = 0.469). Conclusions: The rs1801274 polymorphism is not associated with severe disease in patients infected with influenza A(H1N1)pdm09.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Pesquisas em Oncologia. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Vírus Respiratórios. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Vírus Respiratórios. Ananindeua, PA, Brasil.Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, Pará, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Vírus Respiratórios. Ananindeua, PA, Brasil.Universidade Federal do Pará. Núcleo de Pesquisas em Oncologia. Belém, PA, Brasil / Universidade Federal do Pará. Laboratório de Genética Humana e Médica. Belém, Pará, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brazil / Universidade Federal do Pará. Belém, PA, Brasil.engBioMed CentralThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfluenza HumanaPolimorfismo GenéticoPolimorfismo His131ArgH1N1Influenza Ainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECTHUMBNAILThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdf.jpgThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdf.jpgGenerated Thumbnailimage/jpeg5944https://patua.iec.gov.br/bitstreams/842edf25-c7ac-4b89-ba13-843e886e4cd4/download2dd63fc00869bca53b91afe89339758aMD56ORIGINALThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdfThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdfapplication/pdf879296https://patua.iec.gov.br/bitstreams/0029ffc8-669d-40b9-a66e-e4337a143d8c/downloadba7a7b540936cb9e25a81b2548d03fc1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/fe7c1a4d-6d79-4e7a-8e3b-897a19cab499/download52f1732ea66fbd1123abe39f5373b797MD52TEXTThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdf.txtThe His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection.pdf.txtExtracted texttext/plain21240https://patua.iec.gov.br/bitstreams/6c60d3a4-6ba3-4917-9c71-974dc02d313c/download82a7c65f7ccc7dbc53db718b076a24f9MD55iec/24982022-10-20 23:19:44.78oai:patua.iec.gov.br:iec/2498https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:19:44Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
title |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
spellingShingle |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection Maestri, Alvino Influenza Humana Polimorfismo Genético Polimorfismo His131Arg H1N1 Influenza A |
title_short |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
title_full |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
title_fullStr |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
title_full_unstemmed |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
title_sort |
The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection |
author |
Maestri, Alvino |
author_facet |
Maestri, Alvino Sortica, Vinicius Albuquerque Ferreira, Deimy Lima Ferreira, Jessylene de Almeida Amador, Marcos Antônio Trindade Mello, Wyller Alencar de Santos, Sidney Emanuel Batista Sousa, Rita Catarina Medeiros |
author_role |
author |
author2 |
Sortica, Vinicius Albuquerque Ferreira, Deimy Lima Ferreira, Jessylene de Almeida Amador, Marcos Antônio Trindade Mello, Wyller Alencar de Santos, Sidney Emanuel Batista Sousa, Rita Catarina Medeiros |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Maestri, Alvino Sortica, Vinicius Albuquerque Ferreira, Deimy Lima Ferreira, Jessylene de Almeida Amador, Marcos Antônio Trindade Mello, Wyller Alencar de Santos, Sidney Emanuel Batista Sousa, Rita Catarina Medeiros |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Influenza Humana Polimorfismo Genético Polimorfismo His131Arg H1N1 Influenza A |
topic |
Influenza Humana Polimorfismo Genético Polimorfismo His131Arg H1N1 Influenza A |
description |
Background: The virulence and pathogenicity of different influenza strains are responsible for a more or less severe disease. Recent studies have attempted to understand how host genetic factors may influence the clinical presentation of the disease. In the present study, the His131Arg (rs1801274) polymorphism was investigated in individuals from a Brazilian admixed population with a diagnosis of influenza A(H1N1)pdm09 infection. Methods: In the present study, the influence of the His131Arg (rs1801274) polymorphism, a variant of the FCGR2A gene, was investigated in 436 patients with a diagnosis of influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010. Patients were divided into a group of non-hospitalized patients (n = 192) and a group of hospitalized patients (n = 244; 100 of them died). Results: No significant difference in the allele or genotype frequencies of the rs1801274 polymorphism was observed between groups (p = 0.952 and p = 0.388). Multinomial logistic regression showed no effect of the rs1801274 polymorphism on severity or death of patients from the Brazilian admixed population (p = 0.368 and p = 0.469). Conclusions: The rs1801274 polymorphism is not associated with severe disease in patients infected with influenza A(H1N1)pdm09. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-09T19:39:09Z |
dc.date.available.fl_str_mv |
2017-02-09T19:39:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MAESTRI, Alvino et al. The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection. BMC Research Notes, v. 9, p. 296, 2016. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2498 |
dc.identifier.doi.-.fl_str_mv |
10.1186/s13104-016-2096-1 |
identifier_str_mv |
MAESTRI, Alvino et al. The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1) pdm09 infection. BMC Research Notes, v. 9, p. 296, 2016. 10.1186/s13104-016-2096-1 |
url |
https://patua.iec.gov.br/handle/iec/2498 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
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