Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.4/2335 |
Resumo: | Stroke represents the second leading cause of mortality and morbidity worldwide. Ischemic strokes are the most prevalent type of stroke, and they are characterized by a series of pathological events prompted by an arterial occlusion that leads to a heterogeneous pathophysiological response through different hemodynamic phases, namely the hyperacute, acute, subacute, and chronic phases. Stroke treatment is highly reliant on recanalization therapies, which are limited to only a subset of patients due to their narrow therapeutic window; hence, there is a huge need for new stroke treatments. Nonetheless, the vast majority of promising treatments are not effective in the clinical setting due to their inability to cross the blood-brain barrier and reach the brain. In this context, nanotechnology-based approaches such as nanoparticle drug delivery emerge as the most promising option. In this review, we will discuss the current status of nanotechnology in the setting of stroke, focusing on the diverse available nanoparticle approaches targeted to the different pathological and physiological repair mechanisms involved in each of the stroke phases. |
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Therapeutic Nanoparticles for the Different Phases of Ischemic StrokeAVC IsquémicoNanopartículasIschemic StrokeNanoparticlesStroke represents the second leading cause of mortality and morbidity worldwide. Ischemic strokes are the most prevalent type of stroke, and they are characterized by a series of pathological events prompted by an arterial occlusion that leads to a heterogeneous pathophysiological response through different hemodynamic phases, namely the hyperacute, acute, subacute, and chronic phases. Stroke treatment is highly reliant on recanalization therapies, which are limited to only a subset of patients due to their narrow therapeutic window; hence, there is a huge need for new stroke treatments. Nonetheless, the vast majority of promising treatments are not effective in the clinical setting due to their inability to cross the blood-brain barrier and reach the brain. In this context, nanotechnology-based approaches such as nanoparticle drug delivery emerge as the most promising option. In this review, we will discuss the current status of nanotechnology in the setting of stroke, focusing on the diverse available nanoparticle approaches targeted to the different pathological and physiological repair mechanisms involved in each of the stroke phases.RIHUCBernardo-Castro, SAlbino, IBarrera-Sandoval, ÁMTomatis, FSousa, JAMartins, ESimões, SLino, MMFerreira, LSargento-Freitas, J2022-09-19T09:05:05Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/2335engLife (Basel) . 2021 May 26;11(6):482.10.3390/life11060482info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:44Zoai:rihuc.huc.min-saude.pt:10400.4/2335Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:47.852007Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
title |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
spellingShingle |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke Bernardo-Castro, S AVC Isquémico Nanopartículas Ischemic Stroke Nanoparticles |
title_short |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
title_full |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
title_fullStr |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
title_full_unstemmed |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
title_sort |
Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke |
author |
Bernardo-Castro, S |
author_facet |
Bernardo-Castro, S Albino, I Barrera-Sandoval, ÁM Tomatis, F Sousa, JA Martins, E Simões, S Lino, MM Ferreira, L Sargento-Freitas, J |
author_role |
author |
author2 |
Albino, I Barrera-Sandoval, ÁM Tomatis, F Sousa, JA Martins, E Simões, S Lino, MM Ferreira, L Sargento-Freitas, J |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RIHUC |
dc.contributor.author.fl_str_mv |
Bernardo-Castro, S Albino, I Barrera-Sandoval, ÁM Tomatis, F Sousa, JA Martins, E Simões, S Lino, MM Ferreira, L Sargento-Freitas, J |
dc.subject.por.fl_str_mv |
AVC Isquémico Nanopartículas Ischemic Stroke Nanoparticles |
topic |
AVC Isquémico Nanopartículas Ischemic Stroke Nanoparticles |
description |
Stroke represents the second leading cause of mortality and morbidity worldwide. Ischemic strokes are the most prevalent type of stroke, and they are characterized by a series of pathological events prompted by an arterial occlusion that leads to a heterogeneous pathophysiological response through different hemodynamic phases, namely the hyperacute, acute, subacute, and chronic phases. Stroke treatment is highly reliant on recanalization therapies, which are limited to only a subset of patients due to their narrow therapeutic window; hence, there is a huge need for new stroke treatments. Nonetheless, the vast majority of promising treatments are not effective in the clinical setting due to their inability to cross the blood-brain barrier and reach the brain. In this context, nanotechnology-based approaches such as nanoparticle drug delivery emerge as the most promising option. In this review, we will discuss the current status of nanotechnology in the setting of stroke, focusing on the diverse available nanoparticle approaches targeted to the different pathological and physiological repair mechanisms involved in each of the stroke phases. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-09-19T09:05:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.4/2335 |
url |
http://hdl.handle.net/10400.4/2335 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life (Basel) . 2021 May 26;11(6):482. 10.3390/life11060482 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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