Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4102 |
Resumo: | Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure. We describe the IgG antibody response in individuals living in an unstable malaria transmission area in Pará state, Amazon region, Brazil, where an epidemic of P. vivax malaria was recorded and monitored over time. As indicated by epidemiological data, the number of P. vivax-caused malaria cases decreased by approximately 90% after three years and the prevalence of IgG positive to PvMSP1-19 decreased significantly over time, in 2010 (93.4%), 2012 (78.3%), and 2013 (85.1%). Acquisition and decay of the IgG antibody against P. vivax MSP1-19 showed variability among individuals living in areas with recent circulating parasites, where the malaria epidemic was being monitored until transmission had been completely controlled. We also found that previous malaria episodes were associated with an increased in the IgG positivity . Our results showed epidemiological, spatial, temporal and individual variability. The understanding on dynamics of antibodies may have implications for the design of serosurveillance tools for monitoring parasite circulation, especially in a context with spatial and temporal changes in P. vivax malaria transmission. |
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Costa, Edna Maria FAmador, Ednei Charles CSilva, Eliane SAlvarenga, Cassiana OPereira, Pedro EliasPóvoa, Marinete MarinsCunha, Maristela G2020-06-25T03:00:39Z2020-06-25T03:00:39Z2020COSTA, Edna Maria F. et al. Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil. Acta Tropica, v. 209, n. 105537, p. xx, Sept. 2020.0001-706Xhttps://patua.iec.gov.br/handle/iec/410210.1016/j.actatropica.2020.105537Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure. We describe the IgG antibody response in individuals living in an unstable malaria transmission area in Pará state, Amazon region, Brazil, where an epidemic of P. vivax malaria was recorded and monitored over time. As indicated by epidemiological data, the number of P. vivax-caused malaria cases decreased by approximately 90% after three years and the prevalence of IgG positive to PvMSP1-19 decreased significantly over time, in 2010 (93.4%), 2012 (78.3%), and 2013 (85.1%). Acquisition and decay of the IgG antibody against P. vivax MSP1-19 showed variability among individuals living in areas with recent circulating parasites, where the malaria epidemic was being monitored until transmission had been completely controlled. We also found that previous malaria episodes were associated with an increased in the IgG positivity . Our results showed epidemiological, spatial, temporal and individual variability. The understanding on dynamics of antibodies may have implications for the design of serosurveillance tools for monitoring parasite circulation, especially in a context with spatial and temporal changes in P. vivax malaria transmission.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brazil.Secretaria de Saúde do Estado do Pará. Belém, PA, Brazil.Fundação Centro de Hemoterapia e Hematologia do Pará. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brazil.Fundação Centro de Hemoterapia e Hematologia do Pará. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brazil.engElsevierMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalária / transmissãoPlasmodium vivax / parasitologiaAnticorpo IgGProteína 1 de Superfície de MerozoitoMSP1-19info:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdfMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/4bd5f2f0-c70b-40ef-9d82-d26ff0dcc425/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51TEXTMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdf.txtMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/e936c0b9-11b1-438a-8c74-98341f291b71/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdf.jpgMalaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/f43d81e7-9b35-4797-baac-ef89412803ce/download71859d578212107f7f8c49a4ce09d9eeMD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
title |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
spellingShingle |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil Costa, Edna Maria F Malária / transmissão Plasmodium vivax / parasitologia Anticorpo IgG Proteína 1 de Superfície de Merozoito MSP1-19 |
title_short |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
title_full |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
title_fullStr |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
title_full_unstemmed |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
title_sort |
Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil |
author |
Costa, Edna Maria F |
author_facet |
Costa, Edna Maria F Amador, Ednei Charles C Silva, Eliane S Alvarenga, Cassiana O Pereira, Pedro Elias Póvoa, Marinete Marins Cunha, Maristela G |
author_role |
author |
author2 |
Amador, Ednei Charles C Silva, Eliane S Alvarenga, Cassiana O Pereira, Pedro Elias Póvoa, Marinete Marins Cunha, Maristela G |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Edna Maria F Amador, Ednei Charles C Silva, Eliane S Alvarenga, Cassiana O Pereira, Pedro Elias Póvoa, Marinete Marins Cunha, Maristela G |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Malária / transmissão Plasmodium vivax / parasitologia Anticorpo IgG Proteína 1 de Superfície de Merozoito MSP1-19 |
topic |
Malária / transmissão Plasmodium vivax / parasitologia Anticorpo IgG Proteína 1 de Superfície de Merozoito MSP1-19 |
description |
Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure. We describe the IgG antibody response in individuals living in an unstable malaria transmission area in Pará state, Amazon region, Brazil, where an epidemic of P. vivax malaria was recorded and monitored over time. As indicated by epidemiological data, the number of P. vivax-caused malaria cases decreased by approximately 90% after three years and the prevalence of IgG positive to PvMSP1-19 decreased significantly over time, in 2010 (93.4%), 2012 (78.3%), and 2013 (85.1%). Acquisition and decay of the IgG antibody against P. vivax MSP1-19 showed variability among individuals living in areas with recent circulating parasites, where the malaria epidemic was being monitored until transmission had been completely controlled. We also found that previous malaria episodes were associated with an increased in the IgG positivity . Our results showed epidemiological, spatial, temporal and individual variability. The understanding on dynamics of antibodies may have implications for the design of serosurveillance tools for monitoring parasite circulation, especially in a context with spatial and temporal changes in P. vivax malaria transmission. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-06-25T03:00:39Z |
dc.date.available.fl_str_mv |
2020-06-25T03:00:39Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, Edna Maria F. et al. Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil. Acta Tropica, v. 209, n. 105537, p. xx, Sept. 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4102 |
dc.identifier.issn.-.fl_str_mv |
0001-706X |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.actatropica.2020.105537 |
identifier_str_mv |
COSTA, Edna Maria F. et al. Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil. Acta Tropica, v. 209, n. 105537, p. xx, Sept. 2020. 0001-706X 10.1016/j.actatropica.2020.105537 |
url |
https://patua.iec.gov.br/handle/iec/4102 |
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eng |
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eng |
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info:eu-repo/semantics/embargoedAccess |
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Elsevier |
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Elsevier |
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