The cerebrospinal fluid in multiple sclerosis: far beyond the bands
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100100 |
Resumo: | ABSTRACT The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency. A more refined evaluation of disease and therapy status can contribute to better therapeutic choices, particularly in escalation of therapies. This is very relevant taking into account the availability of a greater number of drugs for multiple sclerosis treatment in recent years. In this review, we critically evaluate the current literature regarding the most important cerebrospinal fluid biomarkers in multiple sclerosis. The determination of biomarkers levels, such as chemokine ligand 13, fetuin A, and mainly light neurofilament has shown promising results in the evaluation of this disease, providing information that along with clinical and neuroimaging data may contribute to better therapeutic decisions. |
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The cerebrospinal fluid in multiple sclerosis: far beyond the bandsMultiple sclerosisCerebrospinal fluidBiomarkersChemokine CXCL13FetuinsNeurofilament proteinsABSTRACT The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency. A more refined evaluation of disease and therapy status can contribute to better therapeutic choices, particularly in escalation of therapies. This is very relevant taking into account the availability of a greater number of drugs for multiple sclerosis treatment in recent years. In this review, we critically evaluate the current literature regarding the most important cerebrospinal fluid biomarkers in multiple sclerosis. The determination of biomarkers levels, such as chemokine ligand 13, fetuin A, and mainly light neurofilament has shown promising results in the evaluation of this disease, providing information that along with clinical and neuroimaging data may contribute to better therapeutic decisions.Instituto Israelita de Ensino e Pesquisa Albert Einstein2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100100einstein (São Paulo) v.15 n.1 2017reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082017rw3706info:eu-repo/semantics/openAccessDomingues,Renan BarrosFernandes,Gustavo Bruniera PeresLeite,Fernando Brunale Vilela de MouraTilbery,Charles PeterThomaz,Rodrigo BarbosaSilva,Gisele SampaioMangueira,Cristóvão Luis PitangueiraSoares,Carlos Augusto Senneeng2017-10-16T00:00:00Zoai:scielo:S1679-45082017000100100Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-10-16T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
title |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
spellingShingle |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands Domingues,Renan Barros Multiple sclerosis Cerebrospinal fluid Biomarkers Chemokine CXCL13 Fetuins Neurofilament proteins |
title_short |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
title_full |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
title_fullStr |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
title_full_unstemmed |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
title_sort |
The cerebrospinal fluid in multiple sclerosis: far beyond the bands |
author |
Domingues,Renan Barros |
author_facet |
Domingues,Renan Barros Fernandes,Gustavo Bruniera Peres Leite,Fernando Brunale Vilela de Moura Tilbery,Charles Peter Thomaz,Rodrigo Barbosa Silva,Gisele Sampaio Mangueira,Cristóvão Luis Pitangueira Soares,Carlos Augusto Senne |
author_role |
author |
author2 |
Fernandes,Gustavo Bruniera Peres Leite,Fernando Brunale Vilela de Moura Tilbery,Charles Peter Thomaz,Rodrigo Barbosa Silva,Gisele Sampaio Mangueira,Cristóvão Luis Pitangueira Soares,Carlos Augusto Senne |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Domingues,Renan Barros Fernandes,Gustavo Bruniera Peres Leite,Fernando Brunale Vilela de Moura Tilbery,Charles Peter Thomaz,Rodrigo Barbosa Silva,Gisele Sampaio Mangueira,Cristóvão Luis Pitangueira Soares,Carlos Augusto Senne |
dc.subject.por.fl_str_mv |
Multiple sclerosis Cerebrospinal fluid Biomarkers Chemokine CXCL13 Fetuins Neurofilament proteins |
topic |
Multiple sclerosis Cerebrospinal fluid Biomarkers Chemokine CXCL13 Fetuins Neurofilament proteins |
description |
ABSTRACT The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency. A more refined evaluation of disease and therapy status can contribute to better therapeutic choices, particularly in escalation of therapies. This is very relevant taking into account the availability of a greater number of drugs for multiple sclerosis treatment in recent years. In this review, we critically evaluate the current literature regarding the most important cerebrospinal fluid biomarkers in multiple sclerosis. The determination of biomarkers levels, such as chemokine ligand 13, fetuin A, and mainly light neurofilament has shown promising results in the evaluation of this disease, providing information that along with clinical and neuroimaging data may contribute to better therapeutic decisions. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100100 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000100100 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082017rw3706 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.15 n.1 2017 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
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IIEPAE |
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IIEPAE |
reponame_str |
Einstein (São Paulo) |
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Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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