Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001000696 |
Resumo: | ABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection. Methods We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension. Results Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912–1) and 0.78 (0.583–0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p < 0.001 and 0.055, respectively). Conclusion This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker. |
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Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluidBiomarkersplasmacerebrospinal fluidlipidsmultiple sclerosismyelin sheathABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection. Methods We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension. Results Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912–1) and 0.78 (0.583–0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p < 0.001 and 0.055, respectively). Conclusion This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker.Academia Brasileira de Neurologia - ABNEURO2019-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001000696Arquivos de Neuro-Psiquiatria v.77 n.10 2019reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20190122info:eu-repo/semantics/openAccessOLIVEIRA,Enedina Maria Lobato deMONTANI,Daniela AntunesOLIVEIRA-SILVA,DiogoRODRIGUES-OLIVEIRA,André FilipeMATAS,Sandro Luiz de AndradeFERNANDES,Gustavo Bruniera PeresSILVA,Ismael Dale Cotrim Guerreiro daLO TURCO,Edson Guimarãeseng2019-10-21T00:00:00Zoai:scielo:S0004-282X2019001000696Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2019-10-21T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
title |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
spellingShingle |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid OLIVEIRA,Enedina Maria Lobato de Biomarkers plasma cerebrospinal fluid lipids multiple sclerosis myelin sheath |
title_short |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
title_full |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
title_fullStr |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
title_full_unstemmed |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
title_sort |
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid |
author |
OLIVEIRA,Enedina Maria Lobato de |
author_facet |
OLIVEIRA,Enedina Maria Lobato de MONTANI,Daniela Antunes OLIVEIRA-SILVA,Diogo RODRIGUES-OLIVEIRA,André Filipe MATAS,Sandro Luiz de Andrade FERNANDES,Gustavo Bruniera Peres SILVA,Ismael Dale Cotrim Guerreiro da LO TURCO,Edson Guimarães |
author_role |
author |
author2 |
MONTANI,Daniela Antunes OLIVEIRA-SILVA,Diogo RODRIGUES-OLIVEIRA,André Filipe MATAS,Sandro Luiz de Andrade FERNANDES,Gustavo Bruniera Peres SILVA,Ismael Dale Cotrim Guerreiro da LO TURCO,Edson Guimarães |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
OLIVEIRA,Enedina Maria Lobato de MONTANI,Daniela Antunes OLIVEIRA-SILVA,Diogo RODRIGUES-OLIVEIRA,André Filipe MATAS,Sandro Luiz de Andrade FERNANDES,Gustavo Bruniera Peres SILVA,Ismael Dale Cotrim Guerreiro da LO TURCO,Edson Guimarães |
dc.subject.por.fl_str_mv |
Biomarkers plasma cerebrospinal fluid lipids multiple sclerosis myelin sheath |
topic |
Biomarkers plasma cerebrospinal fluid lipids multiple sclerosis myelin sheath |
description |
ABSTRACT The diagnosis of multiple sclerosis (MS) has changed over the last decade, but remains a composite of clinical assessment and magnetic resonance imaging to prove dissemination of lesions in time and space. The intrathecal synthesis of immunoglobulin may be a nonspecific marker and there are no plasma biomarkers that are useful in the diagnosis of MS, presenting additional challenges to their early detection. Methods We performed a preliminary untargeted qualitative lipidomics mass spectrometry analysis, comparing cerebrospinal fluid (CSF) and plasma samples from patients with MS, other inflammatory neurological diseases and idiopathic intracranial hypertension. Results Lipid identification revealed that fatty acids and sphingolipids were the most abundant classes of lipids in the CSF and that glycerolipids and fatty acids were the main class of lipids in the plasma of patients with MS. The area under the curve was 0.995 (0.912–1) and 0.78 (0.583–0.917), respectively. The permutation test indicated that this ion combination was useful for distinguishing MS from other inflammatory diseases (p < 0.001 and 0.055, respectively). Conclusion This study concluded that the CSF and plasma from patients with MS bear a unique lipid signature that can be useful as a diagnostic biomarker. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001000696 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001000696 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20190122 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.77 n.10 2019 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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