MHC structure and function – antigen presentation. Part 1

Detalhes bibliográficos
Autor(a) principal: Goldberg,Anna Carla
Data de Publicação: 2015
Outros Autores: Rizzo,Luiz Vicente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000100027
Resumo: The setting for the occurrence of an immune response is that of the need to cope with a vast array of different antigens from both pathogenic and non-pathogenic sources. When the first barriers against infection and innate defense fail, adaptive immune response enters the stage for recognition of the antigens by means of extremely variable molecules, namely immunoglobulins and T-cell receptors. The latter recognize the antigen exposed on cell surfaces, in the form of peptides presented by the HLA molecule. The first part of this review details the central role played by these molecules, establishing the close connection existing between their structure and their antigen presenting function.
id IIEPAE-1_f0b52d1510ac86eec6af41225c2de44e
oai_identifier_str oai:scielo:S1679-45082015000100027
network_acronym_str IIEPAE-1
network_name_str Einstein (São Paulo)
repository_id_str
spelling MHC structure and function – antigen presentation. Part 1Major histocompatibility complexAntigen presentationHLA genesImmune responseThe setting for the occurrence of an immune response is that of the need to cope with a vast array of different antigens from both pathogenic and non-pathogenic sources. When the first barriers against infection and innate defense fail, adaptive immune response enters the stage for recognition of the antigens by means of extremely variable molecules, namely immunoglobulins and T-cell receptors. The latter recognize the antigen exposed on cell surfaces, in the form of peptides presented by the HLA molecule. The first part of this review details the central role played by these molecules, establishing the close connection existing between their structure and their antigen presenting function.Instituto Israelita de Ensino e Pesquisa Albert Einstein2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000100027einstein (São Paulo) v.13 n.1 2015reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082015RB3122info:eu-repo/semantics/openAccessGoldberg,Anna CarlaRizzo,Luiz Vicenteeng2015-08-03T00:00:00Zoai:scielo:S1679-45082015000100027Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2015-08-03T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv MHC structure and function – antigen presentation. Part 1
title MHC structure and function – antigen presentation. Part 1
spellingShingle MHC structure and function – antigen presentation. Part 1
Goldberg,Anna Carla
Major histocompatibility complex
Antigen presentation
HLA genes
Immune response
title_short MHC structure and function – antigen presentation. Part 1
title_full MHC structure and function – antigen presentation. Part 1
title_fullStr MHC structure and function – antigen presentation. Part 1
title_full_unstemmed MHC structure and function – antigen presentation. Part 1
title_sort MHC structure and function – antigen presentation. Part 1
author Goldberg,Anna Carla
author_facet Goldberg,Anna Carla
Rizzo,Luiz Vicente
author_role author
author2 Rizzo,Luiz Vicente
author2_role author
dc.contributor.author.fl_str_mv Goldberg,Anna Carla
Rizzo,Luiz Vicente
dc.subject.por.fl_str_mv Major histocompatibility complex
Antigen presentation
HLA genes
Immune response
topic Major histocompatibility complex
Antigen presentation
HLA genes
Immune response
description The setting for the occurrence of an immune response is that of the need to cope with a vast array of different antigens from both pathogenic and non-pathogenic sources. When the first barriers against infection and innate defense fail, adaptive immune response enters the stage for recognition of the antigens by means of extremely variable molecules, namely immunoglobulins and T-cell receptors. The latter recognize the antigen exposed on cell surfaces, in the form of peptides presented by the HLA molecule. The first part of this review details the central role played by these molecules, establishing the close connection existing between their structure and their antigen presenting function.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000100027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000100027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1679-45082015RB3122
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.13 n.1 2015
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
_version_ 1752129908302151680

Registros relacionados