Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Dias, Luiz Candido de Souza
Data de Publicação: 1986
Outros Autores: Olivier, Celso Eduardo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/87512
Resumo: In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation.
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spelling Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni Insucesso na indução de resistência a drogas esquistossomicidas em uma cepa brasileira humana de Schistosoma mansoni In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation. No presente estudo, realizou-se uma tentativa de indução de resistência a 3 drogas esquistossomicidas em uma cepa brasileira de S. mansoni, segundo o esquema de indução de resistência tipo II preconizado por JANSMA et al. em 1977. Houve insucesso nas 3 tentativas realizadas. A geração parental tratada com a droga durante o estágio imaturo do verme mostrou-se menos suscetível aos quimioterápicos do que as gerações F1 e F2 do verme. Uma hipótese é levantada para a explicação do fato. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1986-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/87512Revista do Instituto de Medicina Tropical de São Paulo; Vol. 28 No. 5 (1986); 352-357Revista do Instituto de Medicina Tropical de São Paulo; Vol. 28 Núm. 5 (1986); 352-357Revista do Instituto de Medicina Tropical de São Paulo; v. 28 n. 5 (1986); 352-3571678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/87512/90470Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessDias, Luiz Candido de SouzaOlivier, Celso Eduardo2014-11-10T12:51:58Zoai:revistas.usp.br:article/87512Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:27.694128Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
Insucesso na indução de resistência a drogas esquistossomicidas em uma cepa brasileira humana de Schistosoma mansoni
title Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
spellingShingle Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
Dias, Luiz Candido de Souza
title_short Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
title_full Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
title_fullStr Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
title_full_unstemmed Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
title_sort Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni
author Dias, Luiz Candido de Souza
author_facet Dias, Luiz Candido de Souza
Olivier, Celso Eduardo
author_role author
author2 Olivier, Celso Eduardo
author2_role author
dc.contributor.author.fl_str_mv Dias, Luiz Candido de Souza
Olivier, Celso Eduardo
description In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation.
publishDate 1986
dc.date.none.fl_str_mv 1986-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/87512
url https://www.revistas.usp.br/rimtsp/article/view/87512
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/87512/90470
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 28 No. 5 (1986); 352-357
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 28 Núm. 5 (1986); 352-357
Revista do Instituto de Medicina Tropical de São Paulo; v. 28 n. 5 (1986); 352-357
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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