Bisphosphonates and maxillary osteonecrosis: literature review and two case reports

Detalhes bibliográficos
Autor(a) principal: Gegler, Aderson
Data de Publicação: 2006
Outros Autores: Cherubini, Karen, Figueiredo, Maria Antônia Z., Yurgel, Liliane Soares, Azambuja, Alan A.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1904
Resumo: Bisphosphonates are widely used in patients with bone metastases and osteoporosis. They reduce bone resorption, stimulate osteoblastic activity, and inhibit recruitment and promote osteoclastic apoptosis. The association between bisphosphonates and a peculiar maxillary osteonecrosis has been reported, mainly after tooth extraction. This study presents two cases of maxillary osteonecrosis in patients using bisphosphonates for bone metastases. There is no treatment consensus in the literature, but long-term antibiotics appear to provide the best results. The possibility of drug substitution should be analyzed by a multidisciplinary staff. Due to the difficulty in treating this condition and the risk involved in maxillary surgical interventions, patients scheduled to receive bisphosphonates should be carefully examined and all necessary surgical procedures should be performed prior to initiating bisphosphonate therapy.
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spelling Bisphosphonates and maxillary osteonecrosis: literature review and two case reportsBisfosfonatos e osteonecrose maxilar: revisão da literatura e relato de dois casosBisfosfonatosOsteonecroseExtração dentáriaMetástase neoplásicaBisphosphonatesOsteonecrosisTooth extractionTumor metastasisBisphosphonates are widely used in patients with bone metastases and osteoporosis. They reduce bone resorption, stimulate osteoblastic activity, and inhibit recruitment and promote osteoclastic apoptosis. The association between bisphosphonates and a peculiar maxillary osteonecrosis has been reported, mainly after tooth extraction. This study presents two cases of maxillary osteonecrosis in patients using bisphosphonates for bone metastases. There is no treatment consensus in the literature, but long-term antibiotics appear to provide the best results. The possibility of drug substitution should be analyzed by a multidisciplinary staff. Due to the difficulty in treating this condition and the risk involved in maxillary surgical interventions, patients scheduled to receive bisphosphonates should be carefully examined and all necessary surgical procedures should be performed prior to initiating bisphosphonate therapy.Os bisfosfonatos são medicamentos amplamente administrados a pacientes portadores de metástases tumorais em tecido ósseo e a pacientes com osteoporose. A droga reduz a reabsorção óssea, estimula a atividade osteoblástica, assim como inibe o recrutamento e promove a apoptose de osteoclastos. A associação entre o uso dos bisfosfonatos e uma forma peculiar de osteonecrose dos maxilares tem sido relatada, principalmente, em pacientes submetidos a exodontias. No presente estudo, são apresentados dois casos de pacientes em uso de bisfosfonatos para tratamento de metástases ósseas, que desenvolveram osteonecrose maxilar. Na literatura, não há relatos de um tratamento eficaz para a enfermidade, porém o uso de antibióticos por um longo período parece apresentar os melhores resultados. Ainda, a possibilidade de substituição do medicamento deve ser considerada dentro de uma equipe multidisciplinar. Tendo em vista a dificuldade de tratamento e o risco representado pelas intervenções cirúrgicas dos maxilares, pacientes que serão submetidos ao uso de bisfosfonatos devem passar por um criterioso exame odontológico, e todos os procedimentos cirúrgicos necessários devem ser realizados previamente ao início da terapia com o medicamento.INCA2006-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/190410.32635/2176-9745.RBC.2006v52n1.1904Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 25-31Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 25-31Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 25-312176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1904/1156Gegler, Aderson Cherubini, Karen Figueiredo, Maria Antônia Z. Yurgel, Liliane Soares Azambuja, Alan A. info:eu-repo/semantics/openAccess2021-11-29T20:28:49Zoai:rbc.inca.gov.br:article/1904Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:28:49Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
Bisfosfonatos e osteonecrose maxilar: revisão da literatura e relato de dois casos
title Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
spellingShingle Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
Gegler, Aderson
Bisfosfonatos
Osteonecrose
Extração dentária
Metástase neoplásica
Bisphosphonates
Osteonecrosis
Tooth extraction
Tumor metastasis
title_short Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
title_full Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
title_fullStr Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
title_full_unstemmed Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
title_sort Bisphosphonates and maxillary osteonecrosis: literature review and two case reports
author Gegler, Aderson
author_facet Gegler, Aderson
Cherubini, Karen
Figueiredo, Maria Antônia Z.
Yurgel, Liliane Soares
Azambuja, Alan A.
author_role author
author2 Cherubini, Karen
Figueiredo, Maria Antônia Z.
Yurgel, Liliane Soares
Azambuja, Alan A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gegler, Aderson
Cherubini, Karen
Figueiredo, Maria Antônia Z.
Yurgel, Liliane Soares
Azambuja, Alan A.
dc.subject.por.fl_str_mv Bisfosfonatos
Osteonecrose
Extração dentária
Metástase neoplásica
Bisphosphonates
Osteonecrosis
Tooth extraction
Tumor metastasis
topic Bisfosfonatos
Osteonecrose
Extração dentária
Metástase neoplásica
Bisphosphonates
Osteonecrosis
Tooth extraction
Tumor metastasis
description Bisphosphonates are widely used in patients with bone metastases and osteoporosis. They reduce bone resorption, stimulate osteoblastic activity, and inhibit recruitment and promote osteoclastic apoptosis. The association between bisphosphonates and a peculiar maxillary osteonecrosis has been reported, mainly after tooth extraction. This study presents two cases of maxillary osteonecrosis in patients using bisphosphonates for bone metastases. There is no treatment consensus in the literature, but long-term antibiotics appear to provide the best results. The possibility of drug substitution should be analyzed by a multidisciplinary staff. Due to the difficulty in treating this condition and the risk involved in maxillary surgical interventions, patients scheduled to receive bisphosphonates should be carefully examined and all necessary surgical procedures should be performed prior to initiating bisphosphonate therapy.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Relato de Caso
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1904
10.32635/2176-9745.RBC.2006v52n1.1904
url https://rbc.inca.gov.br/index.php/revista/article/view/1904
identifier_str_mv 10.32635/2176-9745.RBC.2006v52n1.1904
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1904/1156
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 52 No. 1 (2006): Jan./Feb./Mar.; 25-31
Revista Brasileira de Cancerologia; Vol. 52 Núm. 1 (2006): ene./feb./mar.; 25-31
Revista Brasileira de Cancerologia; v. 52 n. 1 (2006): jan./fev./mar.; 25-31
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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