Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9747 |
Resumo: | ObjectiveThe purpose of this research was to evaluate adverse events, serum biochemistry, growth and nutritional status of children with difficult-to-control seizures who were submitted to ketogenic diet. MethodsTwenty-three patients aging from 2 to 17 years with refractory epilepsies, where 43.5% (n=10) were males and56.5% (n=13) females from the Sector of Neuropediatrics, Discipline of Neurology of the Universidade Federalde São Paulo, were treated with the ketogenic diet and followed up for at least 1 year. Two patients were notable to achieve persistent ketosis either because they rejected the diets or their parents did not comply. ResultsAdverse events were all reversible and included hyperlipidemia, constipation (17.4%), nausea and vomiting (43.4%), drowsiness (47.8%), intercurrent infections (3.0%), diet refusal (13.0%) and epistaxis (4.3%). Growthwas not affected in the short term and most heights remained within the normal centile lines. ConclusionThe ketogenic diet can be considered a safe and effective treatment for children with intractable seizures. |
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Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic dietAvaliação do perfil metabólico, nutricional e efeitos adversos de crianças com epilepsia refratária em uso da dieta cetogênicachilddieteffectsepilepsydietary fatscriançadietaepilepsialipídeos na dietaObjectiveThe purpose of this research was to evaluate adverse events, serum biochemistry, growth and nutritional status of children with difficult-to-control seizures who were submitted to ketogenic diet. MethodsTwenty-three patients aging from 2 to 17 years with refractory epilepsies, where 43.5% (n=10) were males and56.5% (n=13) females from the Sector of Neuropediatrics, Discipline of Neurology of the Universidade Federalde São Paulo, were treated with the ketogenic diet and followed up for at least 1 year. Two patients were notable to achieve persistent ketosis either because they rejected the diets or their parents did not comply. ResultsAdverse events were all reversible and included hyperlipidemia, constipation (17.4%), nausea and vomiting (43.4%), drowsiness (47.8%), intercurrent infections (3.0%), diet refusal (13.0%) and epistaxis (4.3%). Growthwas not affected in the short term and most heights remained within the normal centile lines. ConclusionThe ketogenic diet can be considered a safe and effective treatment for children with intractable seizures.ObjetivoAvaliar os efeitos adversos, o perfil metabólico e o crescimento pôndero-estatural de crianças com crises epilépticas de difícil controle, as quais foram submetidas a dieta cetogênica. MétodosSelecionaram-se 23 pacientes na faixa etária de 2 até 17 anos com epilepsia de difícil controle medicamentoso, sendo 43,5% (n=10) do sexo masculino e 56,5% (n=13) do sexo feminino, provenientes do Setor de Neuropediatria da Disciplina de Neurologia da Universidade Federal de São Paulo. Foram submetidos a dieta cetogênica e acompanhados por um período mínimo de um ano. Dois pacientes não conseguiram manter a cetose por falta de adesão dos pais à dieta. ResultadosOs efeitos adversos encontrados foram reversíveis, incluindo hiperlipidemia, obstipação (17,4%), náuseas e vômitos (43,4%), sonolência (47,8%), infecções intercorrentes (3,0%), recusa da dieta (13,0%) e epistaxe (4,3%). O crescimento pôndero-estatural não foi afetado, tendo o peso e a estatura seguido o percentil adequado. ConclusãoA dieta cetogênica pode constituir-se em uma alternativa segura e efetiva para o tratamento de crianças com epilepsia refratária.Núcleo de Editoração – PUC-Campinas2023-09-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9747Brazilian Journal of Nutrition; Vol. 19 No. 5 (2006): Revista de NutriçãoRevista de Nutrição; Vol. 19 Núm. 5 (2006): Revista de NutriçãoRevista de Nutrição; v. 19 n. 5 (2006): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9747/7087Copyright (c) 2023 Sueli RIZZUTTI, Ana Maria Figueiredo RAMOS, Isa de Pádua CINTRA, Mauro MUSZKAT, Alberto Alain GABBAIhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRIZZUTTI, Sueli Figueiredo RAMOS, Ana Maria CINTRA, Isa de Pádua MUSZKAT, Mauro Alain GABBAI, Alberto 2023-09-18T19:11:34Zoai:ojs.periodicos.puc-campinas.edu.br:article/9747Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-18T19:11:34Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet Avaliação do perfil metabólico, nutricional e efeitos adversos de crianças com epilepsia refratária em uso da dieta cetogênica |
title |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
spellingShingle |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet RIZZUTTI, Sueli child diet effects epilepsy dietary fats criança dieta epilepsia lipídeos na dieta |
title_short |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
title_full |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
title_fullStr |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
title_full_unstemmed |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
title_sort |
Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet |
author |
RIZZUTTI, Sueli |
author_facet |
RIZZUTTI, Sueli Figueiredo RAMOS, Ana Maria CINTRA, Isa de Pádua MUSZKAT, Mauro Alain GABBAI, Alberto |
author_role |
author |
author2 |
Figueiredo RAMOS, Ana Maria CINTRA, Isa de Pádua MUSZKAT, Mauro Alain GABBAI, Alberto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
RIZZUTTI, Sueli Figueiredo RAMOS, Ana Maria CINTRA, Isa de Pádua MUSZKAT, Mauro Alain GABBAI, Alberto |
dc.subject.por.fl_str_mv |
child diet effects epilepsy dietary fats criança dieta epilepsia lipídeos na dieta |
topic |
child diet effects epilepsy dietary fats criança dieta epilepsia lipídeos na dieta |
description |
ObjectiveThe purpose of this research was to evaluate adverse events, serum biochemistry, growth and nutritional status of children with difficult-to-control seizures who were submitted to ketogenic diet. MethodsTwenty-three patients aging from 2 to 17 years with refractory epilepsies, where 43.5% (n=10) were males and56.5% (n=13) females from the Sector of Neuropediatrics, Discipline of Neurology of the Universidade Federalde São Paulo, were treated with the ketogenic diet and followed up for at least 1 year. Two patients were notable to achieve persistent ketosis either because they rejected the diets or their parents did not comply. ResultsAdverse events were all reversible and included hyperlipidemia, constipation (17.4%), nausea and vomiting (43.4%), drowsiness (47.8%), intercurrent infections (3.0%), diet refusal (13.0%) and epistaxis (4.3%). Growthwas not affected in the short term and most heights remained within the normal centile lines. ConclusionThe ketogenic diet can be considered a safe and effective treatment for children with intractable seizures. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9747 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9747 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/9747/7087 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 19 No. 5 (2006): Revista de Nutrição Revista de Nutrição; Vol. 19 Núm. 5 (2006): Revista de Nutrição Revista de Nutrição; v. 19 n. 5 (2006): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1799126075140210688 |