Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/142606 |
Resumo: | ERC-2016-CoG 725034 |
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Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugsCelecoxibLTTMNSAIDSolubilityTherapeutic liquid formulationsPharmaceutical ScienceERC-2016-CoG 725034Most nonsteroidal anti-inflammatory drugs (NSAIDs) present poor aqueous solubility, impairing their efficiency in physiological media. In this context, Low Transition Temperature Mixtures (LTTMs) are a promising platform to overcome drugs’ poor solubility, forming therapeutic liquid formulations. In this work, the LTTMs of citric acid:L-arginine:water (C:A:W) and glyc-erol:sorbitol (G:S) were studied in terms of their features and assessed in terms of their ability to increase the solubility of six NSAIDs in physiological media. The physicochemical properties of LTTMs were characterized by state-of-art techniques commonly used for these systems. The cyto-toxicity of G:S was also evaluated in L929 mouse fibroblasts and the viscosity, polarity, and pH properties of the studied mixtures were related to the solubility of NSAIDs. The pH and polarity were the parameters that most influenced the drugs’ solubility. Ibuprofen, naproxen, ketoprofen, indomethacin, and flurbiprofen did not present any solubility improvement in the formulations tested. However, concentrated mixtures of C:A:W or G:S in the physiologic-mimicked media (PBS) rendered a celecoxib solubility 4 and 5 times higher than PBS, respectively. These therapeutic liquid formulations of celecoxib in C:A:W or G:S can be a promising tool to increase celecoxib’s therapeutic efficiency in local applications.DQ - Departamento de QuímicaLAQV@REQUIMTERUNRoda, AnaPaiva, AlexandreDuarte, Ana Rita C.2022-07-28T22:25:19Z2021-10-052021-10-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/142606eng1999-4923PURE: 45671973https://doi.org/10.3390/pharmaceutics13101620info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:20:25Zoai:run.unl.pt:10362/142606Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:25.286963Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
title |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
spellingShingle |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs Roda, Ana Celecoxib LTTM NSAID Solubility Therapeutic liquid formulations Pharmaceutical Science |
title_short |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
title_full |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
title_fullStr |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
title_full_unstemmed |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
title_sort |
Therapeutic liquid formulations based on low transition temperature mixtures for the incorporation of anti-inflammatory drugs |
author |
Roda, Ana |
author_facet |
Roda, Ana Paiva, Alexandre Duarte, Ana Rita C. |
author_role |
author |
author2 |
Paiva, Alexandre Duarte, Ana Rita C. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
DQ - Departamento de Química LAQV@REQUIMTE RUN |
dc.contributor.author.fl_str_mv |
Roda, Ana Paiva, Alexandre Duarte, Ana Rita C. |
dc.subject.por.fl_str_mv |
Celecoxib LTTM NSAID Solubility Therapeutic liquid formulations Pharmaceutical Science |
topic |
Celecoxib LTTM NSAID Solubility Therapeutic liquid formulations Pharmaceutical Science |
description |
ERC-2016-CoG 725034 |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-05 2021-10-05T00:00:00Z 2022-07-28T22:25:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/142606 |
url |
http://hdl.handle.net/10362/142606 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4923 PURE: 45671973 https://doi.org/10.3390/pharmaceutics13101620 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138101203828736 |