Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads

Detalhes bibliográficos
Autor(a) principal: Shi, Jun
Data de Publicação: 2006
Outros Autores: Alves, N. M., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/13491
Resumo: A series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH¼2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH¼7.4. The release rate of the drug was higher at 37 8Cthan that at 25 8C and increased slightly with increasing PNIPAAM content. These results suggest that the Caalginate/ PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents.
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spelling Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beadsAlginateBiomaterialsDrug delivery systemsPH/temperature responsiveScience & TechnologyA series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH¼2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH¼7.4. The release rate of the drug was higher at 37 8Cthan that at 25 8C and increased slightly with increasing PNIPAAM content. These results suggest that the Caalginate/ PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents.Wiley-BlackwellUniversidade do MinhoShi, JunAlves, N. M.Mano, J. F.20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/13491eng1616-518710.1002/mabi.20060001316671051info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:44Zoai:repositorium.sdum.uminho.pt:1822/13491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:32.810880Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
title Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
spellingShingle Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
Shi, Jun
Alginate
Biomaterials
Drug delivery systems
PH/temperature responsive
Science & Technology
title_short Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
title_full Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
title_fullStr Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
title_full_unstemmed Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
title_sort Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads
author Shi, Jun
author_facet Shi, Jun
Alves, N. M.
Mano, J. F.
author_role author
author2 Alves, N. M.
Mano, J. F.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Shi, Jun
Alves, N. M.
Mano, J. F.
dc.subject.por.fl_str_mv Alginate
Biomaterials
Drug delivery systems
PH/temperature responsive
Science & Technology
topic Alginate
Biomaterials
Drug delivery systems
PH/temperature responsive
Science & Technology
description A series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH¼2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH¼7.4. The release rate of the drug was higher at 37 8Cthan that at 25 8C and increased slightly with increasing PNIPAAM content. These results suggest that the Caalginate/ PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/13491
url http://hdl.handle.net/1822/13491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1616-5187
10.1002/mabi.200600013
16671051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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