The importance of spheroids in analyzing nanomedicine efficacy

Detalhes bibliográficos
Autor(a) principal: Mó, Inês
Data de Publicação: 2020
Outros Autores: Sabino, Ivo, Diogo, Duarte de Melo, Sousa, Rita Lima, Alves, Cátia, Correia, I.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/10380
Resumo: The use of nanomedicines for cancer treatment holds a great potential due to their improved efficacy and safety. During the nanomedicine preclinical in vitro evaluation stage, these are mainly tested on cell culture monolayers. However, these 2D models are an unrealistic representation of the in vivo tumors, leading to an inaccurate screening of the candidate formulations. To address this problem, spheroids are emerging as an additional tool to validate the efficacy of new therapeutics due to the ability of these 3D in vitro cancer models to mimic the key features displayed by in vivo solid tumors. In this review, the application of spheroids for the evaluation of nanomedicines' physicochemical properties and therapeutic efficacy is discussed.
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spelling The importance of spheroids in analyzing nanomedicine efficacy2D in vitro models3D modelsCancer - OncologyNanomaterialsSpheroidsTherapeuticsThe use of nanomedicines for cancer treatment holds a great potential due to their improved efficacy and safety. During the nanomedicine preclinical in vitro evaluation stage, these are mainly tested on cell culture monolayers. However, these 2D models are an unrealistic representation of the in vivo tumors, leading to an inaccurate screening of the candidate formulations. To address this problem, spheroids are emerging as an additional tool to validate the efficacy of new therapeutics due to the ability of these 3D in vitro cancer models to mimic the key features displayed by in vivo solid tumors. In this review, the application of spheroids for the evaluation of nanomedicines' physicochemical properties and therapeutic efficacy is discussed.Future MedicineuBibliorumMó, InêsSabino, IvoDiogo, Duarte de MeloSousa, Rita LimaAlves, CátiaCorreia, I.J.2022-07-27T00:30:22Z2020-06-182020-06-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/10380eng10.2217/nnm-2020-0054info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:52:07Zoai:ubibliorum.ubi.pt:10400.6/10380Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:50:21.397252Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The importance of spheroids in analyzing nanomedicine efficacy
title The importance of spheroids in analyzing nanomedicine efficacy
spellingShingle The importance of spheroids in analyzing nanomedicine efficacy
Mó, Inês
2D in vitro models
3D models
Cancer - Oncology
Nanomaterials
Spheroids
Therapeutics
title_short The importance of spheroids in analyzing nanomedicine efficacy
title_full The importance of spheroids in analyzing nanomedicine efficacy
title_fullStr The importance of spheroids in analyzing nanomedicine efficacy
title_full_unstemmed The importance of spheroids in analyzing nanomedicine efficacy
title_sort The importance of spheroids in analyzing nanomedicine efficacy
author Mó, Inês
author_facet Mó, Inês
Sabino, Ivo
Diogo, Duarte de Melo
Sousa, Rita Lima
Alves, Cátia
Correia, I.J.
author_role author
author2 Sabino, Ivo
Diogo, Duarte de Melo
Sousa, Rita Lima
Alves, Cátia
Correia, I.J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Mó, Inês
Sabino, Ivo
Diogo, Duarte de Melo
Sousa, Rita Lima
Alves, Cátia
Correia, I.J.
dc.subject.por.fl_str_mv 2D in vitro models
3D models
Cancer - Oncology
Nanomaterials
Spheroids
Therapeutics
topic 2D in vitro models
3D models
Cancer - Oncology
Nanomaterials
Spheroids
Therapeutics
description The use of nanomedicines for cancer treatment holds a great potential due to their improved efficacy and safety. During the nanomedicine preclinical in vitro evaluation stage, these are mainly tested on cell culture monolayers. However, these 2D models are an unrealistic representation of the in vivo tumors, leading to an inaccurate screening of the candidate formulations. To address this problem, spheroids are emerging as an additional tool to validate the efficacy of new therapeutics due to the ability of these 3D in vitro cancer models to mimic the key features displayed by in vivo solid tumors. In this review, the application of spheroids for the evaluation of nanomedicines' physicochemical properties and therapeutic efficacy is discussed.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-18
2020-06-18T00:00:00Z
2022-07-27T00:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/10380
url http://hdl.handle.net/10400.6/10380
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.2217/nnm-2020-0054
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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