Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

Detalhes bibliográficos
Autor(a) principal: Marques, C.
Data de Publicação: 2018
Outros Autores: Fernandes, I., Meireles, M., Faria, A., Spencer, J.P.E., Mateus, N., Calhau, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1038/s41598-018-29744-5
Resumo: This article was supported by FEDER through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013). SFRH/BD/93073/2013; SFRH/BPD/86173/2012; UID/QUI/50006/2013.
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spelling Gut microbiota modulation accounts for the neuroprotective properties of anthocyaninsSDG 3 - Good Health and Well-beingThis article was supported by FEDER through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013). SFRH/BD/93073/2013; SFRH/BPD/86173/2012; UID/QUI/50006/2013.High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins. © 2018, The Author(s).NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMarques, C.Fernandes, I.Meireles, M.Faria, A.Spencer, J.P.E.Mateus, N.Calhau, C.2018-09-26T22:07:05Z2018-07-272018-07-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1038/s41598-018-29744-5eng2045-2322PURE: 5917471https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050774161&doi=10.1038%2fs41598-018-29744-5&partnerID=40&md5=b5ce6ba1a114624b4250be6411ba3f1bhttps://doi.org/10.1038/s41598-018-29744-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:24:42Zoai:run.unl.pt:10362/47504Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:32:04.606417Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
spellingShingle Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
Marques, C.
SDG 3 - Good Health and Well-being
title_short Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_full Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_fullStr Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_full_unstemmed Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_sort Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
author Marques, C.
author_facet Marques, C.
Fernandes, I.
Meireles, M.
Faria, A.
Spencer, J.P.E.
Mateus, N.
Calhau, C.
author_role author
author2 Fernandes, I.
Meireles, M.
Faria, A.
Spencer, J.P.E.
Mateus, N.
Calhau, C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Marques, C.
Fernandes, I.
Meireles, M.
Faria, A.
Spencer, J.P.E.
Mateus, N.
Calhau, C.
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description This article was supported by FEDER through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013). SFRH/BD/93073/2013; SFRH/BPD/86173/2012; UID/QUI/50006/2013.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-26T22:07:05Z
2018-07-27
2018-07-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1038/s41598-018-29744-5
url https://doi.org/10.1038/s41598-018-29744-5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 5917471
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050774161&doi=10.1038%2fs41598-018-29744-5&partnerID=40&md5=b5ce6ba1a114624b4250be6411ba3f1b
https://doi.org/10.1038/s41598-018-29744-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instacron:RCAAP
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