Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis

Detalhes bibliográficos
Autor(a) principal: Araujo,J.
Data de Publicação: 2006
Outros Autores: Ortíz,R., Velásquez,W., Ortega,J.M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005
Resumo: Differential Pulse Voltammetry (DPV) and Fourier Transformed Infrared Spectroscopy (FTIRS) techniques have been applied and compared, for the azithromycin determination in two different pharmaceutical formulations (capsules and suspension). Both methods were found to be highly precise with high recovery levels (more than 98 %) The analytical results obtained with the electrochemical method showed excellent correlation with the analytical results obtained by FTIRS. The proposed electrochemical methodology presents the advantage over FTIRS of being able to be used directly on azithromycin samples in capsules presentation as well as in suspension, since no interferences were observed from the excipients of the formulation, nevertheless the direct analysis of the suspension was not possible by FTIRS due to excipients interference.
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spelling Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysisazithromycinantibiotic analysisDPV analysiselectrochemical determinationFTIRS analysisDifferential Pulse Voltammetry (DPV) and Fourier Transformed Infrared Spectroscopy (FTIRS) techniques have been applied and compared, for the azithromycin determination in two different pharmaceutical formulations (capsules and suspension). Both methods were found to be highly precise with high recovery levels (more than 98 %) The analytical results obtained with the electrochemical method showed excellent correlation with the analytical results obtained by FTIRS. The proposed electrochemical methodology presents the advantage over FTIRS of being able to be used directly on azithromycin samples in capsules presentation as well as in suspension, since no interferences were observed from the excipients of the formulation, nevertheless the direct analysis of the suspension was not possible by FTIRS due to excipients interference.Sociedade Portuguesa de Electroquímica2006-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005Portugaliae Electrochimica Acta v.24 n.1 2006reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005Araujo,J.Ortíz,R.Velásquez,W.Ortega,J.M.info:eu-repo/semantics/openAccess2024-02-06T17:06:47Zoai:scielo:S0872-19042006000100005Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:00.201011Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
title Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
spellingShingle Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
Araujo,J.
azithromycin
antibiotic analysis
DPV analysis
electrochemical determination
FTIRS analysis
title_short Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
title_full Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
title_fullStr Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
title_full_unstemmed Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
title_sort Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry: Comparison with Fourier Transformed Infrared Spectroscopic Analysis
author Araujo,J.
author_facet Araujo,J.
Ortíz,R.
Velásquez,W.
Ortega,J.M.
author_role author
author2 Ortíz,R.
Velásquez,W.
Ortega,J.M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Araujo,J.
Ortíz,R.
Velásquez,W.
Ortega,J.M.
dc.subject.por.fl_str_mv azithromycin
antibiotic analysis
DPV analysis
electrochemical determination
FTIRS analysis
topic azithromycin
antibiotic analysis
DPV analysis
electrochemical determination
FTIRS analysis
description Differential Pulse Voltammetry (DPV) and Fourier Transformed Infrared Spectroscopy (FTIRS) techniques have been applied and compared, for the azithromycin determination in two different pharmaceutical formulations (capsules and suspension). Both methods were found to be highly precise with high recovery levels (more than 98 %) The analytical results obtained with the electrochemical method showed excellent correlation with the analytical results obtained by FTIRS. The proposed electrochemical methodology presents the advantage over FTIRS of being able to be used directly on azithromycin samples in capsules presentation as well as in suspension, since no interferences were observed from the excipients of the formulation, nevertheless the direct analysis of the suspension was not possible by FTIRS due to excipients interference.
publishDate 2006
dc.date.none.fl_str_mv 2006-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042006000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.24 n.1 2006
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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