Nanomedicine internalization and penetration: why should we use spheroids?

Detalhes bibliográficos
Autor(a) principal: Pinto, Bárbara
Data de Publicação: 2022
Outros Autores: Pacheco, Catarina, Silva, Patrícia, Carvalho-Tavares , Juliana, Sarmento, Bruno, Bousbaa, Hassan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48797/sl.2022.12
Resumo: Cancer is a leading cause of death worldwide and, despite medical advances in the development of new anticancer therapies, drug resistance, complicated side effects and poor efficacy remain a major public health problem. To breakdown the antisuppressive tumour strategies and to improve drug efficiency, nanomedicine is increasingly being used in anticancer therapy studies. Different in vitro experimental models and innovative approaches have been used in cancer research. In this aspect, 3D spheroids have become an attractive tool, overcoming many of the issues associated with using 2D models. Thus, in this review, an overview on 3D spheroids is provided, focusing on their use in the cancer field as a promising platform for nanomedicine studies. Thereafter, we highlight the main drug delivery systems currently developed and their applicability in 3D cell cultures.
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spelling Nanomedicine internalization and penetration: why should we use spheroids?3D tumour spheroidscancernanomedicinetumour microenvironmentCancer is a leading cause of death worldwide and, despite medical advances in the development of new anticancer therapies, drug resistance, complicated side effects and poor efficacy remain a major public health problem. To breakdown the antisuppressive tumour strategies and to improve drug efficiency, nanomedicine is increasingly being used in anticancer therapy studies. Different in vitro experimental models and innovative approaches have been used in cancer research. In this aspect, 3D spheroids have become an attractive tool, overcoming many of the issues associated with using 2D models. Thus, in this review, an overview on 3D spheroids is provided, focusing on their use in the cancer field as a promising platform for nanomedicine studies. Thereafter, we highlight the main drug delivery systems currently developed and their applicability in 3D cell cultures.IUCS-CESPU Publishing2022-04-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48797/sl.2022.12https://doi.org/10.48797/sl.2022.12Scientific Letters; Vol. 1 No. 1 (2022); 32795-5117reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://publicacoes.cespu.pt/index.php/sl/article/view/12https://publicacoes.cespu.pt/index.php/sl/article/view/12/5Copyright (c) 2022 Bárbara Pinto, Catarina Pacheco, Patrícia Silva, Juliana Carvalho-Tavares , Bruno Sarmento, Hassan Bousbaainfo:eu-repo/semantics/openAccessPinto, BárbaraPacheco, CatarinaSilva, PatríciaCarvalho-Tavares , JulianaSarmento, BrunoBousbaa, Hassan2023-04-22T08:45:13Zoai:publicacoes.cespu.pt:article/12Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:46:16.659982Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanomedicine internalization and penetration: why should we use spheroids?
title Nanomedicine internalization and penetration: why should we use spheroids?
spellingShingle Nanomedicine internalization and penetration: why should we use spheroids?
Pinto, Bárbara
3D tumour spheroids
cancer
nanomedicine
tumour microenvironment
title_short Nanomedicine internalization and penetration: why should we use spheroids?
title_full Nanomedicine internalization and penetration: why should we use spheroids?
title_fullStr Nanomedicine internalization and penetration: why should we use spheroids?
title_full_unstemmed Nanomedicine internalization and penetration: why should we use spheroids?
title_sort Nanomedicine internalization and penetration: why should we use spheroids?
author Pinto, Bárbara
author_facet Pinto, Bárbara
Pacheco, Catarina
Silva, Patrícia
Carvalho-Tavares , Juliana
Sarmento, Bruno
Bousbaa, Hassan
author_role author
author2 Pacheco, Catarina
Silva, Patrícia
Carvalho-Tavares , Juliana
Sarmento, Bruno
Bousbaa, Hassan
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Bárbara
Pacheco, Catarina
Silva, Patrícia
Carvalho-Tavares , Juliana
Sarmento, Bruno
Bousbaa, Hassan
dc.subject.por.fl_str_mv 3D tumour spheroids
cancer
nanomedicine
tumour microenvironment
topic 3D tumour spheroids
cancer
nanomedicine
tumour microenvironment
description Cancer is a leading cause of death worldwide and, despite medical advances in the development of new anticancer therapies, drug resistance, complicated side effects and poor efficacy remain a major public health problem. To breakdown the antisuppressive tumour strategies and to improve drug efficiency, nanomedicine is increasingly being used in anticancer therapy studies. Different in vitro experimental models and innovative approaches have been used in cancer research. In this aspect, 3D spheroids have become an attractive tool, overcoming many of the issues associated with using 2D models. Thus, in this review, an overview on 3D spheroids is provided, focusing on their use in the cancer field as a promising platform for nanomedicine studies. Thereafter, we highlight the main drug delivery systems currently developed and their applicability in 3D cell cultures.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-21
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48797/sl.2022.12
https://doi.org/10.48797/sl.2022.12
url https://doi.org/10.48797/sl.2022.12
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://publicacoes.cespu.pt/index.php/sl/article/view/12
https://publicacoes.cespu.pt/index.php/sl/article/view/12/5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IUCS-CESPU Publishing
publisher.none.fl_str_mv IUCS-CESPU Publishing
dc.source.none.fl_str_mv Scientific Letters; Vol. 1 No. 1 (2022); 3
2795-5117
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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