Differential incidence of tongue base cancer in male and female hpv16-transgenic mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/126481 |
Resumo: | Funding Information: Funding: This study was supported by grant IECT-FAPEMA-05796/18 and FAPEMA IECT 30/2018-IECT Saúde, by the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2017); by European Investment Funds by FEDER/COMPETE/POCI—Operational Competitiveness and Internationalization Program, and national funds by FCT—Portuguese Foundation for Science and Technology under projects UID/AGR/04033/2020, UIDB/CVT/00772/2020 and by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE—funded by national funds through the FCT/MCTES (PID-DAC); Project 2SMART-engineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Differential incidence of tongue base cancer in male and female hpv16-transgenic micerole of female sex hormone receptorsCollagenEstrogen receptorMatrix metalloproteinaseProgesterone receptorTongue base cancerImmunology and AllergyMolecular BiologyImmunology and Microbiology(all)Microbiology (medical)Infectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: Funding: This study was supported by grant IECT-FAPEMA-05796/18 and FAPEMA IECT 30/2018-IECT Saúde, by the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2017); by European Investment Funds by FEDER/COMPETE/POCI—Operational Competitiveness and Internationalization Program, and national funds by FCT—Portuguese Foundation for Science and Technology under projects UID/AGR/04033/2020, UIDB/CVT/00772/2020 and by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE—funded by national funds through the FCT/MCTES (PID-DAC); Project 2SMART-engineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.A growing proportion of oropharyngeal squamous cell carcinomas (OPSCC) are associated with infection by high-risk human papillomavirus (HPV). For reasons that remain largely unknown, HPV+OPSCC is significantly more common in men than in women. This study aims to determine the incidence of OPSCC in male and female HPV16-transgenic mice and to explore the role of female sex hormone receptors in the sexual predisposition for HPV+ OPSCC. The tongues of 30-weeks-old HPV16-transgenic male (n = 80) and female (n = 90) and matched wild-type male (n = 10) and female (n = 10) FVB/n mice were screened histologically for intraepithelial and invasive lesions in 2017 at the Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Por-tugal. Expression of estrogen receptors alpha (ERα) and beta (ERβ), progesterone receptors (PR) and matrix metalloproteinase 2 (MMP2) was studied immunohistochemically. Collagen remodeling was studied using picrosirius red. Female mice showed robust ERα and ERβ expression in intraepithelial and invasive lesions, which was accompanied by strong MMP2 expression and marked collagen remodeling. Male mice showed minimal ERα, ERβ and MMP2 expression and unaltered collagen patterns. These results confirm the association of HPV16 with tongue base cancer in both sexes. The higher cancer incidence in female versus male mice contrasts with data from OPSCC patients and is associated with enhanced ER expression via MMP2 upregulation.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNNeto, Clariano Pires de OliveiraMedeiros-Fonseca, BeatrizEstêvão, DiogoMestre, Verónica F.Costa, Natália R.de Andrade, Fábio EvangelistaOliveira, Paula A.Bastos, Margarida M.S.M.Medeiros, RuiAssis, DiogoFélix, AnaLopes, Fernanda FerreiraGil da Costa, Rui M.Brito, Haissa O.Brito, Luciane M.O.2021-10-22T03:43:05Z2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/126481eng2076-0817PURE: 34091043https://doi.org/10.3390/pathogens10101224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:54Zoai:run.unl.pt:10362/126481Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:53.780054Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice role of female sex hormone receptors |
| title |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| spellingShingle |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice Neto, Clariano Pires de Oliveira Collagen Estrogen receptor Matrix metalloproteinase Progesterone receptor Tongue base cancer Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being |
| title_short |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| title_full |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| title_fullStr |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| title_full_unstemmed |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| title_sort |
Differential incidence of tongue base cancer in male and female hpv16-transgenic mice |
| author |
Neto, Clariano Pires de Oliveira |
| author_facet |
Neto, Clariano Pires de Oliveira Medeiros-Fonseca, Beatriz Estêvão, Diogo Mestre, Verónica F. Costa, Natália R. de Andrade, Fábio Evangelista Oliveira, Paula A. Bastos, Margarida M.S.M. Medeiros, Rui Assis, Diogo Félix, Ana Lopes, Fernanda Ferreira Gil da Costa, Rui M. Brito, Haissa O. Brito, Luciane M.O. |
| author_role |
author |
| author2 |
Medeiros-Fonseca, Beatriz Estêvão, Diogo Mestre, Verónica F. Costa, Natália R. de Andrade, Fábio Evangelista Oliveira, Paula A. Bastos, Margarida M.S.M. Medeiros, Rui Assis, Diogo Félix, Ana Lopes, Fernanda Ferreira Gil da Costa, Rui M. Brito, Haissa O. Brito, Luciane M.O. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Neto, Clariano Pires de Oliveira Medeiros-Fonseca, Beatriz Estêvão, Diogo Mestre, Verónica F. Costa, Natália R. de Andrade, Fábio Evangelista Oliveira, Paula A. Bastos, Margarida M.S.M. Medeiros, Rui Assis, Diogo Félix, Ana Lopes, Fernanda Ferreira Gil da Costa, Rui M. Brito, Haissa O. Brito, Luciane M.O. |
| dc.subject.por.fl_str_mv |
Collagen Estrogen receptor Matrix metalloproteinase Progesterone receptor Tongue base cancer Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being |
| topic |
Collagen Estrogen receptor Matrix metalloproteinase Progesterone receptor Tongue base cancer Immunology and Allergy Molecular Biology Immunology and Microbiology(all) Microbiology (medical) Infectious Diseases SDG 3 - Good Health and Well-being |
| description |
Funding Information: Funding: This study was supported by grant IECT-FAPEMA-05796/18 and FAPEMA IECT 30/2018-IECT Saúde, by the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2017); by European Investment Funds by FEDER/COMPETE/POCI—Operational Competitiveness and Internationalization Program, and national funds by FCT—Portuguese Foundation for Science and Technology under projects UID/AGR/04033/2020, UIDB/CVT/00772/2020 and by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE—funded by national funds through the FCT/MCTES (PID-DAC); Project 2SMART-engineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-10-22T03:43:05Z 2021-10 2021-10-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/126481 |
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http://hdl.handle.net/10362/126481 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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2076-0817 PURE: 34091043 https://doi.org/10.3390/pathogens10101224 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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