Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

Detalhes bibliográficos
Autor(a) principal: de Castro, Baltazar
Data de Publicação: 1998
Outros Autores: Gameiro, Paula, Guimarães, Carla, Lima, José L.F.C, Reis, Salette
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/8258
Resumo: The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.
id RCAP_214bd7b619d40cabc61055d2156eb52a
oai_identifier_str oai:bdigital.ufp.pt:10284/8258
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Fluorimetric and solubility studies of nadolol and atenolol in SDS micellesb-blockersSDS micellesSpectrofluorimetrySolubilityBinding constantsThe effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.ElsevierRepositório Institucional da Universidade Fernando Pessoade Castro, BaltazarGameiro, PaulaGuimarães, CarlaLima, José L.F.CReis, Salette2019-11-27T12:55:21Z1998-01-01T00:00:00Z1998-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/8258eng0731-708510.1016/S0731-7085(98)00211-8metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:39Zoai:bdigital.ufp.pt:10284/8258Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:45:10.090015Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
title Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
spellingShingle Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
de Castro, Baltazar
b-blockers
SDS micelles
Spectrofluorimetry
Solubility
Binding constants
title_short Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
title_full Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
title_fullStr Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
title_full_unstemmed Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
title_sort Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
author de Castro, Baltazar
author_facet de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
author_role author
author2 Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C
Reis, Salette
dc.subject.por.fl_str_mv b-blockers
SDS micelles
Spectrofluorimetry
Solubility
Binding constants
topic b-blockers
SDS micelles
Spectrofluorimetry
Solubility
Binding constants
description The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01T00:00:00Z
1998-01-01T00:00:00Z
2019-11-27T12:55:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/8258
url http://hdl.handle.net/10284/8258
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0731-7085
10.1016/S0731-7085(98)00211-8
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130317946093568

Registros relacionados