An ASIC for electrical stimulation and signal acquisition of GBM/Polymer scaffolds

• Autor(a) principal: Oliveira, Francisco José Neves de
• Data de Publicação: 2023
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/40209
• topic: Acquisition system; ASIC; Integrated circuit; Layout; Padframe; Stimulation system; Scaffolds; SCI

Tetraplegia and paraplegia are caused by spinal cord injuries, mostly caused by road traffic accidents. Therapies for the treatment of these injuries have been studied for many years. This work deals with part of the implementation of an electrical device capable of stimulating, electrically, and acquiring electrical values from an implant in the area of injury, the scaffold. Contextually, this work is part of a project called NeuroStimSpinal, which aims at a solution for this type of lesions based on the stimulation of 3D printed scaffolds. The device discussed in this work is an integrated circuit for specific applications, which was the result of the junction of two separately developed systems: the stimulation system and the acquisition system. The stimulation system is composed of an SPI interface, a digital-toanalog converter, a programmable current source capable of providing a stimulation current of 200μA through an H-bridge. The acquisition system is composed of a measurement block, an analog to digital converter, and also an SPI communication interface. The integrated circuit has a total area of 0.4mm². Following on from two dissertations already completed, this work focuses essentially on the design of the PAD layout and the choice of the appropriate package for the integrated circuit, as well as the whole process of ordering its manufacture. For implementation of the work, Cadence software was used. During the chip manufacturing process, a backup system with discrete components capable of stimulating a load with a given current, externally controlled, was designed. This system was implemented following the design and development process of a product (design, implementation, testing and validation).