Hypotensive effects of genistein: from chemistry to medicine

Detalhes bibliográficos
Autor(a) principal: Sureda, Antoni
Data de Publicação: 2017
Outros Autores: Sanches Silva, Ana, Sánchez-Machado, Dalia Isabel, López-Cervantes, Jaime, Daglia, Maria, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5442
Resumo: Genistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure.
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spelling Hypotensive effects of genistein: from chemistry to medicineAnimalsAntihypertensive AgentsGenisteinHumansHypertensionSegurança AlimentarGenistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure.A. Sureda was supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN - CB12/03/30038). Transparency document TransparencyElsevierRepositório Científico do Instituto Nacional de SaúdeSureda, AntoniSanches Silva, AnaSánchez-Machado, Dalia IsabelLópez-Cervantes, JaimeDaglia, MariaNabavi, Seyed FazelNabavi, Seyed Mohammad2018-03-22T17:52:17Z2017-04-252017-04-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5442engChem Biol Interact. 2017 Apr 25;268:37-46. doi: 10.1016/j.cbi.2017.02.012. Epub 2017 Feb 24.0009-279710.1016/j.cbi.2017.02.012info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:52Zoai:repositorio.insa.pt:10400.18/5442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:08.090775Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hypotensive effects of genistein: from chemistry to medicine
title Hypotensive effects of genistein: from chemistry to medicine
spellingShingle Hypotensive effects of genistein: from chemistry to medicine
Sureda, Antoni
Animals
Antihypertensive Agents
Genistein
Humans
Hypertension
Segurança Alimentar
title_short Hypotensive effects of genistein: from chemistry to medicine
title_full Hypotensive effects of genistein: from chemistry to medicine
title_fullStr Hypotensive effects of genistein: from chemistry to medicine
title_full_unstemmed Hypotensive effects of genistein: from chemistry to medicine
title_sort Hypotensive effects of genistein: from chemistry to medicine
author Sureda, Antoni
author_facet Sureda, Antoni
Sanches Silva, Ana
Sánchez-Machado, Dalia Isabel
López-Cervantes, Jaime
Daglia, Maria
Nabavi, Seyed Fazel
Nabavi, Seyed Mohammad
author_role author
author2 Sanches Silva, Ana
Sánchez-Machado, Dalia Isabel
López-Cervantes, Jaime
Daglia, Maria
Nabavi, Seyed Fazel
Nabavi, Seyed Mohammad
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Sureda, Antoni
Sanches Silva, Ana
Sánchez-Machado, Dalia Isabel
López-Cervantes, Jaime
Daglia, Maria
Nabavi, Seyed Fazel
Nabavi, Seyed Mohammad
dc.subject.por.fl_str_mv Animals
Antihypertensive Agents
Genistein
Humans
Hypertension
Segurança Alimentar
topic Animals
Antihypertensive Agents
Genistein
Humans
Hypertension
Segurança Alimentar
description Genistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-25
2017-04-25T00:00:00Z
2018-03-22T17:52:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5442
url http://hdl.handle.net/10400.18/5442
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chem Biol Interact. 2017 Apr 25;268:37-46. doi: 10.1016/j.cbi.2017.02.012. Epub 2017 Feb 24.
0009-2797
10.1016/j.cbi.2017.02.012
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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