Hypotensive effects of genistein: from chemistry to medicine
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/5442 |
Resumo: | Genistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure. |
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Hypotensive effects of genistein: from chemistry to medicineAnimalsAntihypertensive AgentsGenisteinHumansHypertensionSegurança AlimentarGenistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure.A. Sureda was supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN - CB12/03/30038). Transparency document TransparencyElsevierRepositório Científico do Instituto Nacional de SaúdeSureda, AntoniSanches Silva, AnaSánchez-Machado, Dalia IsabelLópez-Cervantes, JaimeDaglia, MariaNabavi, Seyed FazelNabavi, Seyed Mohammad2018-03-22T17:52:17Z2017-04-252017-04-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5442engChem Biol Interact. 2017 Apr 25;268:37-46. doi: 10.1016/j.cbi.2017.02.012. Epub 2017 Feb 24.0009-279710.1016/j.cbi.2017.02.012info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:52Zoai:repositorio.insa.pt:10400.18/5442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:08.090775Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypotensive effects of genistein: from chemistry to medicine |
title |
Hypotensive effects of genistein: from chemistry to medicine |
spellingShingle |
Hypotensive effects of genistein: from chemistry to medicine Sureda, Antoni Animals Antihypertensive Agents Genistein Humans Hypertension Segurança Alimentar |
title_short |
Hypotensive effects of genistein: from chemistry to medicine |
title_full |
Hypotensive effects of genistein: from chemistry to medicine |
title_fullStr |
Hypotensive effects of genistein: from chemistry to medicine |
title_full_unstemmed |
Hypotensive effects of genistein: from chemistry to medicine |
title_sort |
Hypotensive effects of genistein: from chemistry to medicine |
author |
Sureda, Antoni |
author_facet |
Sureda, Antoni Sanches Silva, Ana Sánchez-Machado, Dalia Isabel López-Cervantes, Jaime Daglia, Maria Nabavi, Seyed Fazel Nabavi, Seyed Mohammad |
author_role |
author |
author2 |
Sanches Silva, Ana Sánchez-Machado, Dalia Isabel López-Cervantes, Jaime Daglia, Maria Nabavi, Seyed Fazel Nabavi, Seyed Mohammad |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Sureda, Antoni Sanches Silva, Ana Sánchez-Machado, Dalia Isabel López-Cervantes, Jaime Daglia, Maria Nabavi, Seyed Fazel Nabavi, Seyed Mohammad |
dc.subject.por.fl_str_mv |
Animals Antihypertensive Agents Genistein Humans Hypertension Segurança Alimentar |
topic |
Animals Antihypertensive Agents Genistein Humans Hypertension Segurança Alimentar |
description |
Genistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properties that make this molecule a potential agent for the prevention and treatment of a number of chronic diseases. Growing evidence suggests that genistein could act as a vasodilating, anti-thrombotic, and anti-atherosclerotic agent, exerting these effects through different mechanisms of action. This paper aims to review data from the literature assessing the beneficial effects of genistein on hypertension, one of the most important cardiovascular disease risk factors along with hyperglycemia and hyperlidipemia. In addition, we discuss the chemistry, main sources and bioavailability of genistein. Scientific findings support genistein's potential as a promising anti-hypertensive agent in different experimental models. However, clinical trials are very limited and more research will be required before genistein intake can be recommended as part of therapies targeting raised blood pressure. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-25 2017-04-25T00:00:00Z 2018-03-22T17:52:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/5442 |
url |
http://hdl.handle.net/10400.18/5442 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chem Biol Interact. 2017 Apr 25;268:37-46. doi: 10.1016/j.cbi.2017.02.012. Epub 2017 Feb 24. 0009-2797 10.1016/j.cbi.2017.02.012 |
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info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132142066728960 |