Drug-Derived Surface-Active Ionic Liquids
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/149142 |
Resumo: | Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH |
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Drug-Derived Surface-Active Ionic LiquidsA Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of PrimaquineAntimalarialblood-stagefatty acidionic liquidliver-stagePlasmodiumSAILsurface activityBiochemistryMolecular MedicinePharmacologyDrug DiscoveryPharmacology, Toxicology and Pharmaceutics(all)Organic ChemistryPharmacology (medical)SDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureSDG 12 - Responsible Consumption and ProductionFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbHInspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNSilva, Ana TeresaOliveira, Isabel S.Gomes, JoanaAguiar, LuísaFontinha, DianaDuarte, DeniseNogueira, FátimaPrudêncio, MiguelMarques, Eduardo F.Teixeira, CátiaFerraz, RicardoGomes, Paula2023-02-13T22:17:57Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/149142eng1860-7179PURE: 36004524https://doi.org/10.1002/cmdc.202100650info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:09:08Zoai:run.unl.pt:10362/149142Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:09:08Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Drug-Derived Surface-Active Ionic Liquids A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine |
| title |
Drug-Derived Surface-Active Ionic Liquids |
| spellingShingle |
Drug-Derived Surface-Active Ionic Liquids Silva, Ana Teresa Antimalarial blood-stage fatty acid ionic liquid liver-stage Plasmodium SAIL surface activity Biochemistry Molecular Medicine Pharmacology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Organic Chemistry Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 12 - Responsible Consumption and Production |
| title_short |
Drug-Derived Surface-Active Ionic Liquids |
| title_full |
Drug-Derived Surface-Active Ionic Liquids |
| title_fullStr |
Drug-Derived Surface-Active Ionic Liquids |
| title_full_unstemmed |
Drug-Derived Surface-Active Ionic Liquids |
| title_sort |
Drug-Derived Surface-Active Ionic Liquids |
| author |
Silva, Ana Teresa |
| author_facet |
Silva, Ana Teresa Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
| author_role |
author |
| author2 |
Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) RUN |
| dc.contributor.author.fl_str_mv |
Silva, Ana Teresa Oliveira, Isabel S. Gomes, Joana Aguiar, Luísa Fontinha, Diana Duarte, Denise Nogueira, Fátima Prudêncio, Miguel Marques, Eduardo F. Teixeira, Cátia Ferraz, Ricardo Gomes, Paula |
| dc.subject.por.fl_str_mv |
Antimalarial blood-stage fatty acid ionic liquid liver-stage Plasmodium SAIL surface activity Biochemistry Molecular Medicine Pharmacology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Organic Chemistry Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 12 - Responsible Consumption and Production |
| topic |
Antimalarial blood-stage fatty acid ionic liquid liver-stage Plasmodium SAIL surface activity Biochemistry Molecular Medicine Pharmacology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Organic Chemistry Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 12 - Responsible Consumption and Production |
| description |
Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03 2022-03-01T00:00:00Z 2023-02-13T22:17:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/149142 |
| url |
http://hdl.handle.net/10362/149142 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1860-7179 PURE: 36004524 https://doi.org/10.1002/cmdc.202100650 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817545916472623104 |